PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34500749-2	2021	Two of these substituted 3-nitro-6-amino-imidazo(1,2-b)pyridazine compounds (5c and 5h) showed potent acetylcholinesterase (AChE) inhibitory activity (IC50 40-50 nM), which we have previously reported.	5h	84-86	acetylcholinesterase (Cartwright blood group)	Homo sapiens	124-128	
34931332-7	2022	As a result of activity tests, compounds 5b, 5e, 5g, and 5h showed inhibitory activity against AChE; compounds 5e and 5g showed inhibitory activity against MAO-B.	5h	57-59	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-99	
18333606-4	2008	Molecular docking elucidated that 5h simultaneously bound to the catalytic and peripheral sites in AChE via hydrophobic interactions with Trp86 and Trp286.	5h	34-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-103	
34029971-4	2021	Compounds with para-substituted aromatic moieties (5g, 5h, and bis-amiridine 7) had the highest anti-AChE activity in the low micromolar range.	5h	55-57	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-105	
34029971-5	2021	Top-ranked compound 5h, N-(2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-yl)-2-[4-(4-nitro-phenyl)-piperazin-1-yl]-acetamide, had an IC50 for AChE = 1.83 +- 0.03 muM (Ki = 1.50 +- 0.12 and alphaKi = 2.58 +- 0.23 muM).	5h	20-22	acetylcholinesterase (Cartwright blood group)	Homo sapiens	145-149	
27914796-4	2017	Among the newly synthesized compounds, 5h, 9h, 9j, and 9p displayed higher AChE enzyme inhibitory activities than the standard drug, galantamine, with IC50 values of 0.83, 0.98, and 0.73muM, respectively.	5h	39-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	75-79	
18333606-6	2008	Furthermore, 5h and 5i markedly prevented the AChE-induced Abeta aggregation with IC 50 values of 16.6 and 5.8 microM, similar to that of propidium (IC 50 = 12.8 microM), which suggests promising disease-modifying agents for the treatment of AD patients.	5h	13-15	acetylcholinesterase (Cartwright blood group)	Homo sapiens	46-50