PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27914796-4 2017 Among the newly synthesized compounds, 5h, 9h, 9j, and 9p displayed higher AChE enzyme inhibitory activities than the standard drug, galantamine, with IC50 values of 0.83, 0.98, and 0.73muM, respectively. 5h 39-41 acetylcholinesterase (Cartwright blood group) Homo sapiens 75-79 18333606-4 2008 Molecular docking elucidated that 5h simultaneously bound to the catalytic and peripheral sites in AChE via hydrophobic interactions with Trp86 and Trp286. 5h 34-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 18333606-6 2008 Furthermore, 5h and 5i markedly prevented the AChE-induced Abeta aggregation with IC 50 values of 16.6 and 5.8 microM, similar to that of propidium (IC 50 = 12.8 microM), which suggests promising disease-modifying agents for the treatment of AD patients. 5h 13-15 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-50 34500749-2 2021 Two of these substituted 3-nitro-6-amino-imidazo(1,2-b)pyridazine compounds (5c and 5h) showed potent acetylcholinesterase (AChE) inhibitory activity (IC50 40-50 nM), which we have previously reported. 5h 84-86 acetylcholinesterase (Cartwright blood group) Homo sapiens 124-128 34931332-7 2022 As a result of activity tests, compounds 5b, 5e, 5g, and 5h showed inhibitory activity against AChE; compounds 5e and 5g showed inhibitory activity against MAO-B. 5h 57-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 95-99 34029971-4 2021 Compounds with para-substituted aromatic moieties (5g, 5h, and bis-amiridine 7) had the highest anti-AChE activity in the low micromolar range. 5h 55-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-105 34029971-5 2021 Top-ranked compound 5h, N-(2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-yl)-2-[4-(4-nitro-phenyl)-piperazin-1-yl]-acetamide, had an IC50 for AChE = 1.83 +- 0.03 muM (Ki = 1.50 +- 0.12 and alphaKi = 2.58 +- 0.23 muM). 5h 20-22 acetylcholinesterase (Cartwright blood group) Homo sapiens 145-149