PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26975317-2	2016	Recently, a number of studies have reported the involvement of PrP(C) in dopamine metabolism and signaling, including its interactions with tyrosine hydroxylase (TH) and dopamine receptors.	Dopamine	73-81	prion protein	Mus musculus	63-69	
26975317-10	2016	As a consequence, altered PrP(C) functions may affect the regulation of dopamine metabolism and related neurological disorders.	Dopamine	72-80	prion protein	Mus musculus	26-32	
24975422-3	2014	We recently showed that cellular prion protein (PrP(C)) affects the homeostasis of the dopaminergic system by interfering with dopamine synthesis, content, receptor density and signaling pathways in different brain areas.	Dopamine	87-95	prion protein	Mus musculus	48-54	
26152722-4	2015	Contents of dopamine, tyrosine hydroxylase, and the 5-HT5A serotonin receptor were increased in the cerebral cortex of PrP(-/-), as compared with WT mice.	Dopamine	12-20	prion protein	Mus musculus	119-122	
24975422-7	2014	Altogether, these findings provide new evidence that the PrP(C)/dopamine interaction plays a pivotal role in EtOH addictive properties in mice.	Dopamine	64-72	prion protein	Mus musculus	57-63	
23219665-11	2013	3,4-Dihydroxyphenylacetic acid/DA-ratio was elevated in tg(Prnp-SNCA A30P) mice, suggesting an enhanced DA turnover.	Dopamine	31-33	prion protein	Mus musculus	59-63	
24766164-5	2014	Furthermore, the genetic deletion of PrP(C) down-regulated dopamine D1 receptors and DARPP-32 density in the striatum and decreased dopamine levels in the prefrontal cortex of mice.	Dopamine	59-67	prion protein	Mus musculus	37-43	
24766164-6	2014	This indicates that PrP(C) affects the homeostasis of the dopaminergic system by interfering differently in different brain areas with dopamine synthesis, content, receptor density and signaling pathways.	Dopamine	58-66	prion protein	Mus musculus	20-26	
24766164-7	2014	This interaction between PrP(C) and the dopaminergic system prompts the hypotheses that the dopaminergic system may be implicated in some pathological features of prion-related diseases and, conversely, that PrP(C) may play a role in dopamine-associated brain disorders.	Dopamine	40-48	prion protein	Mus musculus	208-214	
21084837-8	2011	However, co-expression of PrP inhibits BAX-mediated dopamine neuron degeneration, demonstrating for the first time that PrP has anti-BAX activity in living animals.	Dopamine	52-60	prion protein	Mus musculus	26-29	
21084837-8	2011	However, co-expression of PrP inhibits BAX-mediated dopamine neuron degeneration, demonstrating for the first time that PrP has anti-BAX activity in living animals.	Dopamine	52-60	prion protein	Mus musculus	120-123