PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12093814-2	2002	Cytochrome P450 (P450) 2D6 is involved in the oxidation of a large fraction ( approximately 30%) of drugs used by humans and also catalyzes the O-demethylation of the model substrates 3- and 4-methoxyphenethylamine followed by subsequent ring hydroxylation to dopamine.	Dopamine	260-268	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-26	
15662082-3	2004	The mechanism underlying dopamine-induced regulation of the liver cytochrome P-450 expression seems not to be direct, but rather mediated by pituitary hormones and cytokines.	Dopamine	25-33	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	66-82	
30501426-6	2018	CYP-mediated alternative pathways of dopamine and serotonin synthesis may have a significant role in the local production of these neurotransmitters in the brain regions where the disturbances of these neurotransmitter systems are observed in depression and schizophrenia.	Dopamine	37-45	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	0-3	
9731223-3	1998	In this study, we investigated the formation of dopamine from trace amines, using human hepatic microsomes and human cytochrome P450 (CYP) isoforms expressed in yeast.	Dopamine	48-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	117-132	
9731223-3	1998	In this study, we investigated the formation of dopamine from trace amines, using human hepatic microsomes and human cytochrome P450 (CYP) isoforms expressed in yeast.	Dopamine	48-56	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	134-137	
9731223-4	1998	Among the 11 isoforms of human CYP expressed in yeast, CYP2D6 was the only isoform exhibiting strong ability to convert p-tyramine and m-tyramine to dopamine.	Dopamine	149-157	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	31-34	
21401511-7	2011	Moreover, the influence of the peripheral nervous system involving several neurotransmitters (acetylcholine, noradrenaline, adrenaline, dopamine, serotonin) on liver function may also be important for the physiological regulation of hepatic CYP activity.	Dopamine	136-144	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	241-244	
21539368-0	2011	The directive of the protein: how does cytochrome P450 select the mechanism of dopamine formation?	Dopamine	79-87	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	39-54	
21539368-1	2011	Dopamine can be generated from tyramine via arene hydroxylation catalyzed by a cytochrome P450 enzyme (CYP2D6).	Dopamine	0-8	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	79-94