PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10945868-0	2000	Recombinant cytochrome P450 2D18 metabolism of dopamine and arachidonic acid.	Dopamine	47-55	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	23-27	
10945868-7	2000	Because the four aforementioned pharmaceutical substrates work by binding to neurotransmitter receptors, binding assays and oxidation reactions were performed to test whether dopamine is a substrate for P450 2D18.	Dopamine	175-183	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	203-207	
10945868-8	2000	These data indicate a K(S) value of 678 microM and that P450 2D18 can support the oxidation of dopamine to aminochrome through a peroxide-shunt mechanism.	Dopamine	95-103	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	56-60	
10945868-10	2000	The data presented herein suggest a possible role for P450 involvement in membrane and receptor regulation via epoxyeicosatrienoic acid formation and a potential involvement of P450 in the oxidation of dopamine to reactive oxygen species under aberrant physiological conditions where the sequestering of dopamine becomes compromised, such as in Parkinson"s disease.	Dopamine	202-210	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	54-58	
10945868-10	2000	The data presented herein suggest a possible role for P450 involvement in membrane and receptor regulation via epoxyeicosatrienoic acid formation and a potential involvement of P450 in the oxidation of dopamine to reactive oxygen species under aberrant physiological conditions where the sequestering of dopamine becomes compromised, such as in Parkinson"s disease.	Dopamine	202-210	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	177-181	
10945868-10	2000	The data presented herein suggest a possible role for P450 involvement in membrane and receptor regulation via epoxyeicosatrienoic acid formation and a potential involvement of P450 in the oxidation of dopamine to reactive oxygen species under aberrant physiological conditions where the sequestering of dopamine becomes compromised, such as in Parkinson"s disease.	Dopamine	304-312	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	54-58	
33806634-1	2021	The noradrenaline and dopamine reuptake inhibitor bupropion is metabolized by CYP2B6 and recommended by the FDA as the only sensitive substrate for clinical CYP2B6 drug-drug interaction (DDI) studies.	Dopamine	22-30	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	78-84	
33806634-1	2021	The noradrenaline and dopamine reuptake inhibitor bupropion is metabolized by CYP2B6 and recommended by the FDA as the only sensitive substrate for clinical CYP2B6 drug-drug interaction (DDI) studies.	Dopamine	22-30	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	157-163	
10888271-5	2000	We now demonstrate that, in addition to histamine, melatonin and the biogenic amines dopamine, serotonin and noradrenaline bind to P450 isozymes and to cytochrome C.	Dopamine	85-93	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	131-135