PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28532681-0	2018	Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation.	Dopamine	75-83	huntingtin	Homo sapiens	59-69	
28532681-3	2018	We have previously shown that dopamine-induced oxidative stress triggers apoptotic cell death in dopaminergic neuroblastoma SH-SY5Y cells hyper-expressing the mutant polyQ Huntingtin (polyQ-Htt) protein.	Dopamine	30-38	huntingtin	Homo sapiens	172-182	
27840125-5	2016	Here we show that the hyper-expression of mutant (>113/150) polyQ Htt is per se toxic to dopaminergic human neuroblastoma SH-SY5Y cells, and that DA exacerbates this toxicity leading to apoptosis and secondary necrosis.	Dopamine	146-148	huntingtin	Homo sapiens	66-69	
24374792-6	2014	The fact remains that the mutant Htt protein was seen to be associated with mitochondria directly, and as the striatum is highly enriched with dopamine and glutamate, it may make the striatal mitochondria more vulnerable because of the presence of dopa-quinones, and due to an imbalance in Ca(2+).	Dopamine	143-151	huntingtin	Homo sapiens	33-36	
27840125-0	2016	Dopamine exacerbates mutant Huntingtin toxicity via oxidative-mediated inhibition of autophagy in SH-SY5Y neuroblastoma cells: Beneficial effects of anti-oxidant therapeutics.	Dopamine	0-8	huntingtin	Homo sapiens	28-38	
19682570-10	2010	Also dopamine receptors modulate mutant Htt toxicity, at least in part through regulation of the expression of mitochondrial complex II.	Dopamine	5-13	huntingtin	Homo sapiens	40-43	
18829967-2	2008	However, the precise mechanisms by which mutant huntingtin sensitize striatal cells to dopamine and glutamate inputs remain unclear.	Dopamine	87-95	huntingtin	Homo sapiens	48-58	
18844975-0	2008	Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington"s disease.	Dopamine	62-70	huntingtin	Homo sapiens	7-17	
18829967-3	2008	Here, we demonstrate in knock-in HD striatal cells that mutant huntingtin enhances dopamine-mediated striatal cell death via dopamine D(1) receptors.	Dopamine	83-91	huntingtin	Homo sapiens	63-73	
18829967-3	2008	Here, we demonstrate in knock-in HD striatal cells that mutant huntingtin enhances dopamine-mediated striatal cell death via dopamine D(1) receptors.	Dopamine	125-133	huntingtin	Homo sapiens	63-73	
18829967-4	2008	Moreover, we show that NMDA receptors specifically potentiate the vulnerability of mutant huntingtin striatal cells to dopamine toxicity as pretreatment with NMDA increased D(1)R-induced cell death in mutant but not wild-type cells.	Dopamine	119-127	huntingtin	Homo sapiens	90-100	
18267960-0	2008	Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.	Dopamine	0-8	huntingtin	Homo sapiens	95-105	
18267960-3	2008	We show that in primary striatal cultures, dopamine increases the toxicity of an N-terminal fragment of mutated huntingtin (Htt-171-82Q).	Dopamine	43-51	huntingtin	Homo sapiens	112-122	
18403126-4	2008	Although the basis of this specific vulnerability remains unclear, a great deal of evidence has documented the ability of the dopamine system to modulate the toxicity of expanded htt.	Dopamine	126-134	huntingtin	Homo sapiens	179-182	
18267960-3	2008	We show that in primary striatal cultures, dopamine increases the toxicity of an N-terminal fragment of mutated huntingtin (Htt-171-82Q).	Dopamine	43-51	huntingtin	Homo sapiens	124-127	
16854064-2	2006	The results show that binding to the dopamine and serotonin transporters (DAT and 5-HTT) is highly dependent on the specific linker used.	Dopamine	37-45	huntingtin	Homo sapiens	84-87	
32004439-6	2020	Top mutant huntingtin toxicity modifier genes included several Nme genes and several genes involved in methylation-dependent chromatin silencing and dopamine signaling, results that reveal new HD therapeutic target pathways.	Dopamine	149-157	huntingtin	Homo sapiens	11-21	
11406606-7	2001	The results suggest that the combination of mutant huntingtin and a source of oxyradical stress (provided in this case by dopamine) induces autophagy and may underlie the selective cell death characteristic of HD.	Dopamine	122-130	huntingtin	Homo sapiens	51-61	
10362304-8	1999	Dopamine treatment altered the subcellular localization of huntingtin and increased its expression in clathrin-enriched membrane fractions.	Dopamine	0-8	huntingtin	Homo sapiens	59-69	
10362304-10	1999	Results suggest that the transport of huntingtin and its co-expression in clathrin and huntingtin-interacting protein 1-enriched membranes is influenced by activation of adenylyl cyclase and stimulation of dopamine D1 receptors.	Dopamine	206-214	huntingtin	Homo sapiens	38-48