PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32060993-3 2020 We characterized inhibition of human CYP1A1, CYP1A2 and CYP1B1 enzymes by the novel inhibitor N-(3,5-dichlorophenyl) cyclopropanecarboxamide (DCPCC) and alpha-naphthoflavone (ANF). cyclopropanecarboxamide 94-140 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 45-51 32060993-3 2020 We characterized inhibition of human CYP1A1, CYP1A2 and CYP1B1 enzymes by the novel inhibitor N-(3,5-dichlorophenyl) cyclopropanecarboxamide (DCPCC) and alpha-naphthoflavone (ANF). cyclopropanecarboxamide 142-147 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 45-51 32060993-4 2020 Depending on substrate, IC50 values of DCPCC for CYP1A1 or CYP1B1 were 10-95 times higher than for CYP1A2. cyclopropanecarboxamide 39-44 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 99-105 32060993-5 2020 IC50 of DCPCC for CYP1A2 was 100-fold lower than for enzymes in CYP2 and CYP3 families. cyclopropanecarboxamide 8-13 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 18-24 32060993-7 2020 DCPCC was a mixed type inhibitor of CYP1A2. cyclopropanecarboxamide 0-5 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 36-42 32060993-11 2020 We conclude that DCPCC is a more selective inhibitor for CYP1A2 than ANF. cyclopropanecarboxamide 17-22 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 57-63 32060993-12 2020 DCPCC is a candidate structure to modulate CYP1A2 mediated metabolism of procarcinogens and anticancer drugs. cyclopropanecarboxamide 0-5 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 43-49