PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32061138-0 2020 Expression, mutation, and methylation of crbn-pathway genes at pre- and post-lenalidomide treatment in multiple myeloma. lenalidomide 77-89 cereblon Homo sapiens 41-45 31619706-0 2019 Cereblon gene variants and clinical outcome in multiple myeloma patients treated with lenalidomide. lenalidomide 86-98 cereblon Homo sapiens 0-8 32071327-9 2020 The data here show that thalidomide, lenalidomide, and pomalidomide affect stem cell mesendoderm differentiation through CRBN-mediated degradation of SALL4 and highlight the utility of the LPM differentiation model for studying the teratogenicity of new CRBN modulating agents. lenalidomide 37-49 cereblon Homo sapiens 121-125 32071327-9 2020 The data here show that thalidomide, lenalidomide, and pomalidomide affect stem cell mesendoderm differentiation through CRBN-mediated degradation of SALL4 and highlight the utility of the LPM differentiation model for studying the teratogenicity of new CRBN modulating agents. lenalidomide 37-49 cereblon Homo sapiens 254-258 31859249-3 2020 As an alternative strategy to target AKT, we report the development of INY-03-041, a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to lenalidomide, a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN). lenalidomide 173-185 cereblon Homo sapiens 244-252 31859249-3 2020 As an alternative strategy to target AKT, we report the development of INY-03-041, a pan-AKT degrader consisting of the ATP-competitive AKT inhibitor GDC-0068 conjugated to lenalidomide, a recruiter of the E3 ubiquitin ligase substrate adaptor Cereblon (CRBN). lenalidomide 173-185 cereblon Homo sapiens 254-258 31619706-2 2019 Cereblon (CRBN) is the direct molecular target of lenalidomide and genetic polymorphisms in CRBN have been associated with lenalidomide efficacy. lenalidomide 50-62 cereblon Homo sapiens 0-8 31619706-2 2019 Cereblon (CRBN) is the direct molecular target of lenalidomide and genetic polymorphisms in CRBN have been associated with lenalidomide efficacy. lenalidomide 50-62 cereblon Homo sapiens 10-14 31619706-2 2019 Cereblon (CRBN) is the direct molecular target of lenalidomide and genetic polymorphisms in CRBN have been associated with lenalidomide efficacy. lenalidomide 123-135 cereblon Homo sapiens 0-8 31619706-2 2019 Cereblon (CRBN) is the direct molecular target of lenalidomide and genetic polymorphisms in CRBN have been associated with lenalidomide efficacy. lenalidomide 123-135 cereblon Homo sapiens 10-14 31619706-2 2019 Cereblon (CRBN) is the direct molecular target of lenalidomide and genetic polymorphisms in CRBN have been associated with lenalidomide efficacy. lenalidomide 123-135 cereblon Homo sapiens 92-96 31619706-3 2019 In this study, we assessed the correlation of five single nucleotide variants (SNVs) in the CRBN gene with clinical response and outcomes in patients with NDMM administered KRd therapy with lenalidomide maintenance, achieving favorable trial endpoints in a prospective Phase II study (NCT01402284). lenalidomide 190-202 cereblon Homo sapiens 92-96