PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6305994-2	1983	A carbon radical is formed during the oxidative metabolism of phenelzine that reacts with the prosthetic heme of cytochrome P-450 and irreversibly inactivates the enzyme.	Phenelzine	62-72	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	113-129	
6305994-5	1983	The metabolism of phenelzine, an alkyl hydrazine, thus yields a carbon radical that inactivates cytochrome P-450, is converted to a hydrocarbon by hydrogen atom abstraction, and reacts with spin traps or (presumably) alternative cellular targets.	Phenelzine	18-28	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	96-112	
7288604-3	1981	In vitro, the addition of phenelzine produced immediate decrease in cytochrome P-450.	Phenelzine	26-36	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	68-84	
7288604-4	1981	This initial decrease was found to be due to the direct binding of phenelzine to the ferrous heme of cytochrome P-450.	Phenelzine	67-77	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	101-117	
7288604-5	1981	Further decrease in cytochrome P-450 occurred upon incubation of microsomes with phenelzine in the presence of NADPH.	Phenelzine	81-91	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	20-36	
7288604-7	1981	The decrease in cytochrome P-450 with concomitant loss of heme can be partially inhibited by a substrate (aminopyrine) or by an inhibitor (metyrapone) of the microsomal enzymes, indicating the possible involvement of the metabolism of phenelzine to a reactive intermediate.	Phenelzine	235-245	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	16-32	
7288604-8	1981	The comparison of the effect of phenelzine to that of phenylhydrazine strengthened the possibility that a reactive metabolic intermediate of phenelzine can cause heme destruction in cytochrome P-450.	Phenelzine	32-42	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	182-198	
7288604-8	1981	The comparison of the effect of phenelzine to that of phenylhydrazine strengthened the possibility that a reactive metabolic intermediate of phenelzine can cause heme destruction in cytochrome P-450.	Phenelzine	141-151	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	182-198	
7288604-9	1981	Thus, phenelzine exerts its inhibitory action on microsomal drug metabolism most likely by decreasing the cytochrome P-450 content largely through heme destruction.	Phenelzine	6-16	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	106-122