PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23360889-0	2013	Involvement of PKA and HO-1 signaling in anti-inflammatory effects of surfactin in BV-2 microglial cells.	surfactin peptide	70-79	heme oxygenase 1	Mus musculus	23-27	
23360889-6	2013	We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2.	surfactin peptide	26-35	heme oxygenase 1	Mus musculus	44-60	
23360889-6	2013	We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2.	surfactin peptide	26-35	heme oxygenase 1	Mus musculus	62-66	
23360889-6	2013	We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2.	surfactin peptide	26-35	heme oxygenase 1	Mus musculus	251-255	
23360889-6	2013	We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2.	surfactin peptide	179-188	heme oxygenase 1	Mus musculus	62-66	
23360889-6	2013	We also demonstrated that surfactin induces heme oxygenase-1 (HO-1) expression and nuclear factor-regulated factor-2 (Nrf-2) activation, and that the anti-inflammatory effects of surfactin are abrogated by small interfering RNA-mediated knock-down of HO-1 or Nrf-2.	surfactin peptide	179-188	heme oxygenase 1	Mus musculus	251-255	
23360889-8	2013	Furthermore, treatment with the protein kinase A (PKA) inhibitor, H-89, blocked HO-1 induction by surfactin and abolished surfactin"s suppressive effects on ROS and NO production.	surfactin peptide	98-107	heme oxygenase 1	Mus musculus	80-84	
23360889-9	2013	These results indicate that HO-1 and its upstream effector, PKA, play a pivotal role in the anti-neuroinflammatory response of surfactin in LTA-stimulated microglia.	surfactin peptide	127-136	heme oxygenase 1	Mus musculus	28-32	
34716926-12	2022	Additionally, surfactin promoted Nrf2-dependent HO-1 expression in HGFs, mitigating VCAM-1 expression.	surfactin peptide	14-23	heme oxygenase 1	Mus musculus	48-52	
34716926-14	2022	CONCLUSION: Surfactin exerts anti-inflammatory effects against PM-induced inflammatory responses in HGFs by inhibiting VCAM-1-dependent pathway and inducing Nrf2/HO-1 axis.	surfactin peptide	12-21	heme oxygenase 1	Mus musculus	162-166