PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25352364-5 2015 The acetylation of p300 and the phosphorylation of activating transcription factor 2 (ATF-2) induced by LPS were downregulated following treatment with veratric acid; similar effects were observed following treatment with LY294002, a specific inhibitor of PI3K/Akt. veratric acid 152-165 thymoma viral proto-oncogene 1 Mus musculus 261-264 25352364-7 2015 In the measurement of histone acetylation levels, the LPS-stimulated acetylation of histone H4 was significantly attenuated by veratric acid, and was also reduced following the inhibition of PI3K/Akt with LY294002. veratric acid 127-140 thymoma viral proto-oncogene 1 Mus musculus 196-199 25352364-9 2015 Our results suggest that veratric acid impedes the PI3K/Akt-mediated histone acetyl-transferase (HAT) activation and HDAC expression induced by LPS, thereby abrogating iNOS expression. veratric acid 25-38 thymoma viral proto-oncogene 1 Mus musculus 56-59 25352364-4 2015 Veratric acid suppressed the LPS-induced effects on the regulatory and catalytic subunits of phosphoinositide 3-kinase (PI3K), comprised of p85, p110alpha, p110beta and Akt. veratric acid 0-13 thymoma viral proto-oncogene 1 Mus musculus 169-172