PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30772266-0 2019 The role of the Hint1 protein in the metabolism of phosphorothioate oligonucleotides drugs and prodrugs, and the release of H2S under cellular conditions. Deuterium 124-127 histidine triad nucleotide binding protein 1 Homo sapiens 16-21 30772266-4 2019 We previously found that (d)NMPS were desulfurated in vitro to yield (d)NMP and H2S in a Hint1-assisted reaction. Deuterium 80-83 histidine triad nucleotide binding protein 1 Homo sapiens 89-94 30772266-9 2019 These results suggest that the metabolic pathway of PS-oligos includes hydrolysis into (d)NMPS (by cellular nucleases) followed by Hint1-promoted conversion of the resulting (d)NMPS into (d)NMP accompanied by H2S elimination. Deuterium 209-212 histidine triad nucleotide binding protein 1 Homo sapiens 131-136