PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30028131-2 2018 At elevated solution temperatures, we observe a slow protonation reaction, i.e., [BK+2H]2++H+ [BK+3H]3+, that is regulated by trans cis isomerization of Arg1-Pro2, resulting in the Arg1- cis-Pro2- cis-Pro3-Gly4-Phe5-Ser6- cis-Pro7-Phe8-Arg9 (all- cis) configuration. Deuterium 85-87 kininogen 1 Homo sapiens 82-84 2640560-0 1989 Edematous response caused by [Thi5,8,D-Phe7]bradykinin, a B2 receptor antagonist, is due to mast cell degranulation. Deuterium 36-38 kininogen 1 Homo sapiens 44-54 30712581-11 2019 As demonstrated by deuterium retention of bradykinin, these features serve to reduce experimental error normally associated with conventional deuterium exchange experiments. Deuterium 19-28 kininogen 1 Homo sapiens 42-52 30712581-11 2019 As demonstrated by deuterium retention of bradykinin, these features serve to reduce experimental error normally associated with conventional deuterium exchange experiments. Deuterium 142-151 kininogen 1 Homo sapiens 42-52 35412805-1 2022 A high-performance field asymmetric waveform ion mobility spectrometry (FAIMS)-IMS-MS platform was developed and applied to explore the conformational diversity of the singly and doubly charged bradykinin (BK + H+)+ and (BK + 2H+)2+ ions. Deuterium 226-228 kininogen 1 Homo sapiens 194-204 30028131-2 2018 At elevated solution temperatures, we observe a slow protonation reaction, i.e., [BK+2H]2++H+ [BK+3H]3+, that is regulated by trans cis isomerization of Arg1-Pro2, resulting in the Arg1- cis-Pro2- cis-Pro3-Gly4-Phe5-Ser6- cis-Pro7-Phe8-Arg9 (all- cis) configuration. Deuterium 85-87 kininogen 1 Homo sapiens 97-99 20552714-7 2010 In an O-trap installed in a 5 T desk-top cryogen-free superconducting magnet, the resolving power of R = 80,000 was achieved for bradykinin [M + 2H](2+) (m/z 531; equivalent to 100,000 when recalculated for m/z 400) in 0.2 s analysis time (transient length), and R = 300,000 at m/z 531 for a 1 s transient. Deuterium 145-147 kininogen 1 Homo sapiens 129-139 25775573-8 2015 Kinetic studies were carried out in fused water droplets for acid-induced unfolding of cytochrome c and hydrogen-deuterium exchange in bradykinin. Deuterium 113-122 kininogen 1 Homo sapiens 135-145 27173110-0 2016 Use of deuterium labeling by high-temperature solid-state hydrogen-exchange reaction for mass spectrometric analysis of bradykinin biotransformation. Deuterium 7-16 kininogen 1 Homo sapiens 120-130 27173110-9 2016 Deuterium-labeled and unlabeled BKs were incubated with human plasma and their corresponding fragments BK(1-5) and BK(1-7), well known as the major metabolites, were detected. Deuterium 0-9 kininogen 1 Homo sapiens 103-105 11507759-0 2001 Gas-phase conformers of the [M + 2H](2+) ion of bradykinin investigated by combining high-field asymmetric waveform ion mobility spectrometry, hydrogen/deuterium exchange, and energy-loss measurements. Deuterium 33-35 kininogen 1 Homo sapiens 48-58 11507759-2 2001 Gas-phase conformers of the [M + 2H](2+) ion of bradykinin were examined using a combination of FAIMS, H/D exchange, and energy-loss measurements. Deuterium 33-35 kininogen 1 Homo sapiens 48-58 11507759-3 2001 When FAIMS data and H/D exchange data were analyzed separately, the presence of only two conformers of the [M + 2H](2+) ion of bradykinin could be detected. Deuterium 112-114 kininogen 1 Homo sapiens 127-137 11507759-4 2001 However, in an experiment in which FAIMS and H/D exchange were combined, at least four different conformers of the gas-phase [M + 2H](2+) ion of bradykinin were detected, including one of very low abundance. Deuterium 130-132 kininogen 1 Homo sapiens 145-155 18802500-1 2006 Doubly-protonated bradykinin (RPPGFSPFR) and an angiotensin III analogue (RVYIFPF) were subjected to hydrogen/deuterium (H/D) exchange with CD(3)OD in a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. Deuterium 110-119 kininogen 1 Homo sapiens 18-28 18802500-2 2006 A bimodal distribution of deuterium incorporation was present for bradykinin after H/D exchange for 90 s at a CD(3)OD pressure of 4 x 10(-7) Torr, indicating the existence of at least two distinct populations. Deuterium 26-35 kininogen 1 Homo sapiens 66-76 18802500-3 2006 Bradykinin ion populations corresponding to 0-2 and 5-11 deuteriums (i.e., D(0), D(1), D(2), D(5), D(6), D(7), D(8), D(9), D(10), and D(11)) were each monoisotopically selected and fragmented via sustained off-resonance irradiation (SORI) collision-induced dissociation (CID). Deuterium 57-67 kininogen 1 Homo sapiens 0-10 11523086-1 2001 Apparent gas-phase basicities (GB(app)s) for [M + H]+ of bradykinin, des-Arg1-bradykinin and des-Arg9-bradykinin have been assigned by deprotonation reactions of [M + 2H]2+ in a Fourier transform ion cyclotron resonance mass spectrometer. Deuterium 167-169 kininogen 1 Homo sapiens 57-67 11523086-1 2001 Apparent gas-phase basicities (GB(app)s) for [M + H]+ of bradykinin, des-Arg1-bradykinin and des-Arg9-bradykinin have been assigned by deprotonation reactions of [M + 2H]2+ in a Fourier transform ion cyclotron resonance mass spectrometer. Deuterium 167-169 kininogen 1 Homo sapiens 78-88 11523086-1 2001 Apparent gas-phase basicities (GB(app)s) for [M + H]+ of bradykinin, des-Arg1-bradykinin and des-Arg9-bradykinin have been assigned by deprotonation reactions of [M + 2H]2+ in a Fourier transform ion cyclotron resonance mass spectrometer. Deuterium 167-169 kininogen 1 Homo sapiens 78-88 10439510-1 1999 Hydrogen/deuterium (H/D) exchange chemistry monitored by matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry is used to study solution phase conformational changes of bradykinin, alpha-melanocyte stimulating hormone, and melittin as water is added to methanol-d4, acetonitrile, and isopropanol-d8 solutions. Deuterium 9-18 kininogen 1 Homo sapiens 204-214 9650825-12 1998 Progress has been made with AcLys-[D-betaNal7, Ile8]desArg9-bradykinin (R 715) and Lys-Lys-[Hyp3, Cpg5, D-Tic7,Cpg8]desArg9-bradykinin (B 9958) which are pure B1 antagonists in humans and rabbits; both peptides have shown resistance to degradation by peptidases and have little if any, residual agonistic activity on mouse and rat B1 receptors. Deuterium 35-36 kininogen 1 Homo sapiens 60-70 9606729-0 1997 NMR investigations of recombinant 15N/13C/2H-labeled bradykinin bound to a Fab mimic of the B2 receptor. Deuterium 42-44 kininogen 1 Homo sapiens 53-63