PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12062638-12 2002 Finally, generation of reactive oxygen species (which occurs during alcohol metabolism) and products of lipid peroxidation induce production of cytokines, such as TNF and IL-8. Alcohols 68-75 C-X-C motif chemokine ligand 8 Homo sapiens 171-175 16295318-9 2004 The results demonstrate an important oxidative aggression induced by three sources: the alcohol metabolism in the hepatocytes, activated Kupffer cells and activated neutrophils that have infiltrated the liver, due to the chemoattractant effect of IL-8. Alcohols 88-95 C-X-C motif chemokine ligand 8 Homo sapiens 247-251 11169058-0 2000 Neopterin and interleukin-8--prognosis in alcohol-induced cirrhosis. Alcohols 42-49 C-X-C motif chemokine ligand 8 Homo sapiens 14-27 11169058-11 2000 CONCLUSIONS: Neopterin and IL-8 plasma levels are raised in patients with alcohol-induced cirrhosis, and are predictive of mortality associated with infections and upper gastrointestinal bleeding, respectively. Alcohols 74-81 C-X-C motif chemokine ligand 8 Homo sapiens 27-31 9373700-6 1997 Milk from the alcohol group contained an elevated amount of IL-8 as compared with milk from non-smoker controls; however, it did not differ statistically from that of the smoker controls. Alcohols 14-21 C-X-C motif chemokine ligand 8 Homo sapiens 60-64 10976010-6 2000 Serum IL-8 values increased after alcohol intake in healthy subjects. Alcohols 34-41 C-X-C motif chemokine ligand 8 Homo sapiens 6-10 10418175-7 1999 Serum IL-8 levels decreased gradually with abstinence from alcohol. Alcohols 59-66 C-X-C motif chemokine ligand 8 Homo sapiens 6-10 10358198-0 1999 Alcohol (ethanol) inhibits IL-8 and TNF: role of the p38 pathway. Alcohols 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 27-39 9665313-0 1998 Stimulation of monocyte interleukin-8 by lipid peroxidation products: a mechanism for alcohol-induced liver injury. Alcohols 86-93 C-X-C motif chemokine ligand 8 Homo sapiens 24-37 9665313-5 1998 Ethanol-induced lipid peroxidation may secondarily further alcohol-induced liver injury through IL-8 chemotaxis of neutrophils. Alcohols 59-66 C-X-C motif chemokine ligand 8 Homo sapiens 96-100 10080106-0 1999 Acute alcohol consumption attenuates interleukin-8 (IL-8) and monocyte chemoattractant peptide-1 (MCP-1) induction in response to ex vivo stimulation. Alcohols 6-13 C-X-C motif chemokine ligand 8 Homo sapiens 37-50 10080106-0 1999 Acute alcohol consumption attenuates interleukin-8 (IL-8) and monocyte chemoattractant peptide-1 (MCP-1) induction in response to ex vivo stimulation. Alcohols 6-13 C-X-C motif chemokine ligand 8 Homo sapiens 52-56 9373700-7 1997 Blood from the alcohol group showed an increased level of IL-8 when compared with that from both smoker and non-smoker controls. Alcohols 15-22 C-X-C motif chemokine ligand 8 Homo sapiens 58-62 9373700-12 1997 The present study found that alcohol consumption during pregnancy could modulate the production of IL-8 and infiltration of certain leukocytes in milk and blood of postpartum women. Alcohols 29-36 C-X-C motif chemokine ligand 8 Homo sapiens 99-103 8325620-5 1993 In contrast, moderate elevations in the levels of circulating interleukin-8 were seen in alcoholic cirrhosis (geometric mean = 93 ng/L; confidence interval = 40 to 213) and in alcoholic patients undergoing alcohol withdrawal (geometric mean = 137 ng/L; confidence interval = 72 to 259). Alcohols 89-96 C-X-C motif chemokine ligand 8 Homo sapiens 62-75 8116830-2 1993 This study was designed to investigate the relationship between chronic alcohol ingestion and cessation with respect to release of interleukin-6 (IL-6) and interleukin-8 (IL-8) using highly specific and sensitive ELISA assays, as well as a functional assay, natural killer cell cytotoxic activity. Alcohols 72-79 C-X-C motif chemokine ligand 8 Homo sapiens 156-169 8116830-2 1993 This study was designed to investigate the relationship between chronic alcohol ingestion and cessation with respect to release of interleukin-6 (IL-6) and interleukin-8 (IL-8) using highly specific and sensitive ELISA assays, as well as a functional assay, natural killer cell cytotoxic activity. Alcohols 72-79 C-X-C motif chemokine ligand 8 Homo sapiens 171-175 8359798-7 1993 The alcohol-dependent control group and the normal volunteer controls had mean interleukin-8 concentrations of 106 +/- 28 pg/ml and 10 +/- 5 pg/ml, respectively. Alcohols 4-11 C-X-C motif chemokine ligand 8 Homo sapiens 79-92 33887366-8 2021 Our findings demonstrated that these specific non-traditional biomarkers measured together with more conventional ones (e.g., CDT, EtG, IL8, ALT, AST, GGT) could represent novel key parameters for monitoring alcohol use disorders and withdrawal being also suggestive of the complexity of psychoneuroimmune response to alcohol. Alcohols 208-215 C-X-C motif chemokine ligand 8 Homo sapiens 136-139 7908198-4 1993 It was of interest to note that serum IL-8 levels were increased transiently after abstinence from alcohol in patients with alcoholic hepatitis. Alcohols 99-106 C-X-C motif chemokine ligand 8 Homo sapiens 38-42 1024309-5 1976 A study of non-specificity of the adaptive effect of low alcohol decreased their resistance to 0.12 M NaF by 33.3% (P less than 0.05) The same concentration of ethyl alcohol applied for periods from 15 mintes to 2 hours either caused no change or decreased significantly the resistance of muscle tissue to the temperature 36 degrees C. This effect of decrease in resistance was even more significant when the resistance to 38 degrees C was challenged. Alcohols 57-64 C-X-C motif chemokine ligand 8 Homo sapiens 102-105 34305638-16 2021 During alcohol detoxification, LS, transaminases, TGF- beta, IL-6, IL-8 and VEGF decreased significantly. Alcohols 7-14 C-X-C motif chemokine ligand 8 Homo sapiens 67-71 31759072-0 2020 Acute alcohol consumption alters the peripheral cytokines IL-8 and TNF-alpha. Alcohols 6-13 C-X-C motif chemokine ligand 8 Homo sapiens 58-62 33352397-0 2021 IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1alpha pathway in human IL-8-expressing mice. Alcohols 17-24 C-X-C motif chemokine ligand 8 Homo sapiens 0-4 33352397-0 2021 IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1alpha pathway in human IL-8-expressing mice. Alcohols 17-24 C-X-C motif chemokine ligand 8 Homo sapiens 93-97 33352397-6 2021 We found that hIL-8 can exacerbate alcohol-induced fatty liver disease via the Akt/HIF-1alpha pathway. Alcohols 35-42 C-X-C motif chemokine ligand 8 Homo sapiens 14-19 33352397-8 2021 Moreover, hIL-8 could increase the alcohol-induced release of ROS in fatty liver caused by alcohol and exacerbate fatty liver disease. Alcohols 35-42 C-X-C motif chemokine ligand 8 Homo sapiens 10-15 33352397-8 2021 Moreover, hIL-8 could increase the alcohol-induced release of ROS in fatty liver caused by alcohol and exacerbate fatty liver disease. Alcohols 91-98 C-X-C motif chemokine ligand 8 Homo sapiens 10-15 31759072-7 2020 RESULTS: The pro-inflammatory chemokine IL-8 significantly increased 6 hours after alcohol (F(1,34)=4.13, p=0.0002, d"=0.5). Alcohols 83-90 C-X-C motif chemokine ligand 8 Homo sapiens 40-44 31759072-10 2020 CONCLUSIONS: In our exploratory data, acute alcohol challenge (120 mg/dL) elicits dynamic changes in the pro-inflammatory molecules IL-8 and TNF-alpha. Alcohols 44-51 C-X-C motif chemokine ligand 8 Homo sapiens 132-136 28242869-8 2017 Peripheral monocyte response to lipopolysaccharide stimulation was lower in alcohol-dependent subjects compared with controls for the proinflammatory cytokines interleukin-6 and interleukin-8. Alcohols 76-83 C-X-C motif chemokine ligand 8 Homo sapiens 178-191 32139808-0 2021 Hippocampal TNF-death receptors, caspase cell death cascades, and IL-8 in alcohol use disorder. Alcohols 74-81 C-X-C motif chemokine ligand 8 Homo sapiens 66-70 25191838-10 2015 With regard to the mouthwash solutions, the lowest amounts of metal ions were released in CHX, and the highest amounts of metal ions were released in NaF + alcohol. Alcohols 156-163 C-X-C motif chemokine ligand 8 Homo sapiens 150-153 28149283-7 2016 In the alcohol group, CXCL8 concentrations were increased in patients with liver and pancreas diseases and there was a significant correlation to aspartate transaminase (r = +0.456, p < 0.001) and gamma-glutamyltransferase (r = +0.647, p < 0.001). Alcohols 7-14 C-X-C motif chemokine ligand 8 Homo sapiens 22-27 26918409-1 2016 A carbonylative esterification reaction between aryl bromides and alcohols, promoted by Pd/C and NaF in the presence of oxiranes, has been developed. Alcohols 66-74 C-X-C motif chemokine ligand 8 Homo sapiens 91-100 26501345-8 2016 Alcohol ingestion after resistance exercise affected aspects of inflammatory capacity (IL-6 and IL-8 production). Alcohols 0-7 C-X-C motif chemokine ligand 8 Homo sapiens 96-100 25257954-4 2014 Multiple regression analysis showed that the urinary IL-8 level was significantly positively associated with urinary iAs concentration after adjusting for the confounding effects of age, employed years, body mass index (BMI), smoking, alcohol, and seafood consumption in recent 3 days. Alcohols 235-242 C-X-C motif chemokine ligand 8 Homo sapiens 53-57 20843633-7 2011 Increasing carbon chain length of straight chain alcohols positively correlated with their ability to inhibit detection of tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10), but not with the detection of interleukin 6 (IL-6), interleukin 8, (IL-8), and interleukin 12 (IL-12). Alcohols 49-57 C-X-C motif chemokine ligand 8 Homo sapiens 243-256 24629538-12 2014 Activated proinflammatory pathways, in particular, IL-8 and IL-1beta, were positively correlated with alcohol consumption and alcohol-craving scores. Alcohols 102-109 C-X-C motif chemokine ligand 8 Homo sapiens 51-55 24629538-12 2014 Activated proinflammatory pathways, in particular, IL-8 and IL-1beta, were positively correlated with alcohol consumption and alcohol-craving scores. Alcohols 126-133 C-X-C motif chemokine ligand 8 Homo sapiens 51-55 20843633-7 2011 Increasing carbon chain length of straight chain alcohols positively correlated with their ability to inhibit detection of tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10), but not with the detection of interleukin 6 (IL-6), interleukin 8, (IL-8), and interleukin 12 (IL-12). Alcohols 49-57 C-X-C motif chemokine ligand 8 Homo sapiens 259-263 18587146-3 2008 Stepwise multiple regression analyses of factors including age, occupation, years of employment, alcohol drinking behaviour, physical activity, nutritional balance and cigarette smoking parameters showed that LECT was a positively significant predictor (Partial r = 0.0005, P < 0.05) of the comet tail moment. Alcohols 97-104 C-X-C motif chemokine ligand 8 Homo sapiens 209-213 22403977-14 2011 CONCLUSION: The results of this double-blind clinical study support that 1) an alcohol-free mouthwash containing a combination of 0.075% CPC and 0.05% NaF produces statistically significant reductions in dental plaque and gingivitis after three and six months compared to baseline, and 2) the alcohol-free CPC mouthwash provides a statistically significantly greater level of efficacy in controlling established dental plaque and gingivitis after three and six months of product use as compared to the Control Mouthwash containing only NaF. Alcohols 79-86 C-X-C motif chemokine ligand 8 Homo sapiens 151-154 22403977-14 2011 CONCLUSION: The results of this double-blind clinical study support that 1) an alcohol-free mouthwash containing a combination of 0.075% CPC and 0.05% NaF produces statistically significant reductions in dental plaque and gingivitis after three and six months compared to baseline, and 2) the alcohol-free CPC mouthwash provides a statistically significantly greater level of efficacy in controlling established dental plaque and gingivitis after three and six months of product use as compared to the Control Mouthwash containing only NaF. Alcohols 79-86 C-X-C motif chemokine ligand 8 Homo sapiens 536-539 22403977-14 2011 CONCLUSION: The results of this double-blind clinical study support that 1) an alcohol-free mouthwash containing a combination of 0.075% CPC and 0.05% NaF produces statistically significant reductions in dental plaque and gingivitis after three and six months compared to baseline, and 2) the alcohol-free CPC mouthwash provides a statistically significantly greater level of efficacy in controlling established dental plaque and gingivitis after three and six months of product use as compared to the Control Mouthwash containing only NaF. Alcohols 293-300 C-X-C motif chemokine ligand 8 Homo sapiens 151-154 19454816-7 2009 RESULTS: A significant effect of the etiology on the levels of IL-8 in the alcohol group as compared to the gallstone group (P=0.003) was found. Alcohols 75-82 C-X-C motif chemokine ligand 8 Homo sapiens 63-67 19120068-11 2009 Airway cells that were primed with alcohol produced nearly twice as much IL-8 in response to 40 ng of peptidoglycan than naive cells. Alcohols 35-42 C-X-C motif chemokine ligand 8 Homo sapiens 73-77 17576072-0 2007 Serum concentrations of interleukin-8 in relation to different levels of alcohol consumption. Alcohols 73-80 C-X-C motif chemokine ligand 8 Homo sapiens 24-37 17576072-2 2007 The present study was aimed at investigating serum IL-8 levels in relation to different levels of alcohol consumption. Alcohols 98-105 C-X-C motif chemokine ligand 8 Homo sapiens 51-55 17576072-4 2007 The proportion of individuals with abnormally high (>10 pg/mL) IL-8 levels increased with alcohol use from 5.9% in abstainers to 10.7% in light, 13.2% in moderate, and 17.8% in heavy drinkers (P=0.004). Alcohols 93-100 C-X-C motif chemokine ligand 8 Homo sapiens 66-70 17576072-6 2007 Extremely high (>100 pg/mL) IL-8 levels were only observed among alcoholics, and were more frequent in females than in males (23.5% versus 9.7%, P=0.03) in spite of lower alcohol consumption among the former. Alcohols 68-75 C-X-C motif chemokine ligand 8 Homo sapiens 31-35 17576072-7 2007 These data indicate that the effect of alcohol on serum IL-8 levels begins with light-to-moderate drinking and is dose-dependent. Alcohols 39-46 C-X-C motif chemokine ligand 8 Homo sapiens 56-60 17576072-8 2007 Females may be more prone than males to develop extremely high IL-8 levels after heavy alcohol intake. Alcohols 87-94 C-X-C motif chemokine ligand 8 Homo sapiens 63-67