PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28841898-1 2017 BACKGROUND: This study aims to determine the relationship between expression levels of ALDH2 and SOD2 genes and clinical parameters such as alcohol drinking, tobacco smoking, primary site of HNSCC, and human papilloma virus (HPV) state. Alcohols 140-147 superoxide dismutase 2 Homo sapiens 97-101 30815314-7 2019 The mRNA and protein expressions of antioxidant enzymes, such as copper-zinc superoxide dismutase and manganese superoxide dismutase increased in cells treated with the 70% alcohol extract. Alcohols 173-180 superoxide dismutase 2 Homo sapiens 102-132 27207918-0 2016 Association of Superoxide Dismutase 2 (SOD2) Genotype with Gray Matter Volume Shrinkage in Chronic Alcohol Users: Replication and Further Evaluation of an Addiction Gene Panel. Alcohols 99-106 superoxide dismutase 2 Homo sapiens 15-37 27207918-0 2016 Association of Superoxide Dismutase 2 (SOD2) Genotype with Gray Matter Volume Shrinkage in Chronic Alcohol Users: Replication and Further Evaluation of an Addiction Gene Panel. Alcohols 99-106 superoxide dismutase 2 Homo sapiens 39-43 27207918-2 2016 High variance in the degree of gray matter tissue shrinkage among alcohol-dependent individuals and a previous neuroimaging genetics report suggest the involvement of environmental and/or genetic factors, such as superoxide dismutase 2 (SOD2). Alcohols 66-73 superoxide dismutase 2 Homo sapiens 213-235 27207918-2 2016 High variance in the degree of gray matter tissue shrinkage among alcohol-dependent individuals and a previous neuroimaging genetics report suggest the involvement of environmental and/or genetic factors, such as superoxide dismutase 2 (SOD2). Alcohols 66-73 superoxide dismutase 2 Homo sapiens 237-241 27207918-6 2016 RESULTS: We replicated a significant association of a functional SOD2 single nucleotide polymorphism with normalized gray matter volume, which had been reported previously in an independent smaller sample of alcohol-dependent individuals. Alcohols 208-215 superoxide dismutase 2 Homo sapiens 65-69 27207918-9 2016 CONCLUSION: Converging independent evidence for a SOD2 gene association with gray matter volume shrinkage in chronic alcohol users suggests that SOD2 genetic variants predict differential brain volume loss mediated by free radicals. Alcohols 117-124 superoxide dismutase 2 Homo sapiens 50-54 27207918-9 2016 CONCLUSION: Converging independent evidence for a SOD2 gene association with gray matter volume shrinkage in chronic alcohol users suggests that SOD2 genetic variants predict differential brain volume loss mediated by free radicals. Alcohols 117-124 superoxide dismutase 2 Homo sapiens 145-149 26396584-13 2015 Furthermore, the transcription of major antioxidants enzymes (catalase, SOD1, SOD2, GSTK1), and their transcription factor, Nrf2, were reduced in monocytes obtained from HIV positive alcohol users compared to the HIV-negative alcohol user group. Alcohols 183-190 superoxide dismutase 2 Homo sapiens 78-82 23111423-0 2013 The combination of mitochondrial low enzyme-activity aldehyde dehydrogenase 2 allele and superoxide dismutase 2 genotypes increases the risk of hypertension in relation to alcohol consumption. Alcohols 172-179 superoxide dismutase 2 Homo sapiens 89-111 24225087-7 2013 Mice expressing HCV structural proteins on a background of reduced expression of superoxide dismutase 2 (SOD2; Sod2(+/-)) also had increased liver sensitivity to alcohol, with elevated ALT, steatosis, and lobular inflammation. Alcohols 162-169 superoxide dismutase 2 Homo sapiens 105-109 24225087-7 2013 Mice expressing HCV structural proteins on a background of reduced expression of superoxide dismutase 2 (SOD2; Sod2(+/-)) also had increased liver sensitivity to alcohol, with elevated ALT, steatosis, and lobular inflammation. Alcohols 162-169 superoxide dismutase 2 Homo sapiens 111-115 24225087-8 2013 Elevated ALT was associated with an alcohol-induced decrease in SOD2 and redistribution of FOXO3 to the cytosol. Alcohols 36-43 superoxide dismutase 2 Homo sapiens 64-68 23111423-2 2013 The present study examined whether the combination of low enzyme-activity variants of ALDH2 and SOD2 increases the risk of hypertension in relation to alcohol consumption. Alcohols 151-158 superoxide dismutase 2 Homo sapiens 96-100 21940907-11 2011 CONCLUSIONS AND IMPACT: Previously unreported associations of SNPs in ALDH2, CYP2E1, GPX2, SOD1, and SOD2 with SCCHN and subsite tumors provide evidence that alterations in alcohol and oxidative stress pathways influence SCCHN carcinogenesis and warrant further investigation. Alcohols 173-180 superoxide dismutase 2 Homo sapiens 101-105 19451660-11 2009 However, our data suggest a complex gene-to-phenotype interaction between the MnSOD genotype and alcohol misuse. Alcohols 97-104 superoxide dismutase 2 Homo sapiens 78-83 17465268-9 2007 It was concluded that MnSOD Ala allele might be the cause of prostate cancer risk among alcohol users. Alcohols 88-95 superoxide dismutase 2 Homo sapiens 22-27 8024580-1 1994 On the basis of the well-known effect of ethanol poisoning on the prooxidant/antioxidant balance of human and rodent liver we tested the response of the mitochondrial manganese-containing superoxide dismutase (MnSOD) in the liver of rats following an acute ethanol load or chronically intoxicated with an alcohol-supplemented solid diet for three weeks. Alcohols 305-312 superoxide dismutase 2 Homo sapiens 210-215 16933053-8 2006 CONCLUSIONS: The MnSOD Ala-9Val polymorphism may contribute to an increase in breast cancer risk in the context of high alcohol consumption, however the polymorphism is not an overall risk factor for breast cancer in this primarily premenopausal population. Alcohols 120-127 superoxide dismutase 2 Homo sapiens 17-22 9088787-0 1997 Time course of manganese superoxide dismutase concentrations in serum of alcohol-dependent patients during abstinence. Alcohols 73-80 superoxide dismutase 2 Homo sapiens 15-45