PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22402362-10	2012	CONCLUSIONS: Alcohol-induced MMPs activation is a key mechanism for dysfunction of BBB via degradation of VEGFR-2 protein and activation of caspase-1 or IL-1beta release.	Alcohols	13-20	interleukin 1 alpha	Homo sapiens	153-161	
30870525-9	2019	In contrast, the alcohol group showed higher IL-1beta (p<0.01) and lower CXCL12 (p<0.01) concentrations than the control group.	Alcohols	17-24	interleukin 1 alpha	Homo sapiens	45-53	
28853786-0	2016	A randomized controlled cross-over study of the effect of alcohol-free chlorhexidine and essential oils on interleukin-1 levels in crevicular fluid.	Alcohols	58-65	interleukin 1 alpha	Homo sapiens	107-120	
23348156-7	2013	For IL-1 alpha significant predictive parameters included a previous infection of hepatitis B, lower serum level of TGFbeta, age, use of alcohol, lower MELD and Chilld-Pugh scores.	Alcohols	137-144	interleukin 1 alpha	Homo sapiens	4-14	
12436048-14	2002	Further, these results demonstrate that acute alcohol is a potent inhibitor of NF-kappaB activation by mediators of early (LPS) or late (IL-1, TNF(alpha)) stages of inflammation in monocytes.	Alcohols	46-53	interleukin 1 alpha	Homo sapiens	137-141	
19764937-5	2009	RESULTS: Alcohol-dependent patients showed an excess of IL-1alpha-889 C/T [50.8% vs. 39.3%, chi(2) (df) = 7.30 (2), uncorrected p = 0.026, corrected p = 0.104] and IL-1RA (86 bp)(n) A1/A1 genotypes [64.8% vs. 50.8%, chi(2) (df) = 12.65 (3), corrected p = 0.020].	Alcohols	9-16	interleukin 1 alpha	Homo sapiens	56-65	
16600299-4	2007	By analysis of covariance (adjustment for age, gender, coronary heart disease, diabetes, hypertension, smoking, and alcohol consumption) we found that: *IL-1beta was higher in VD, LOAD, and CDND compared with controls (p<0.005).	Alcohols	116-123	interleukin 1 alpha	Homo sapiens	153-161	
16916584-0	2006	Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome.	Alcohols	74-81	interleukin 1 alpha	Homo sapiens	0-19	
15219635-6	2004	In analyses adjusting for age, body mass index (BMI), fasting cholesterol, alcohol use, race and 17beta-estradiol (E(2)), higher Ho scores were associated with greater LPS-stimulated expression of IL-1alpha (beta = 0.033, p = 0.02), IL-8 (beta = 0.046, p = 0.01) and IL-1beta (beta = 0.024, p = 0.06).	Alcohols	75-82	interleukin 1 alpha	Homo sapiens	197-206	
12436048-0	2002	Acute alcohol inhibits the induction of nuclear regulatory factor kappa B activation through CD14/toll-like receptor 4, interleukin-1, and tumor necrosis factor receptors: a common mechanism independent of inhibitory kappa B alpha degradation?	Alcohols	6-13	interleukin 1 alpha	Homo sapiens	120-133	
12436048-11	2002	Inhibition of NF-kappaB by acute alcohol was concomitant with decreased levels of the IkappaB(alpha) molecule in the cytoplasm of LPS, IL-1, and TNFalpha-activated monocytes.	Alcohols	33-40	interleukin 1 alpha	Homo sapiens	135-139	
20800651-6	2010	In multivariate modeling with adjustments for age, gender, obesity, regular smoking, alcohol use, metabolic syndrome, physical exercise, sleep disturbance, and the use of non-steroidal anti-inflammatory drugs, a high level of IL-1 RA was associated with an increased likelihood of belonging to the group with elevated depressive symptoms (OR for each 1 SD increase in the serum level of IL-1 RA: 2.17, 95% CI 1.35-3.48, p=0.001).	Alcohols	85-92	interleukin 1 alpha	Homo sapiens	226-230	
17266151-3	2007	METHODS: Spontaneous and in vitro-stimulated production of interleukin (IL) 1alpha (TNFalpha) by PB monocytes was analyzed at the single level by flow cytometry in chronic alcoholics without liver disease and active ethanol (EtOH) intake (AWLD group), as well as in patients with alcohol liver cirrhosis (ALC group), who were either actively drinking (ALCET group) or with alcohol withdrawal (ALCAW group).	Alcohols	172-179	interleukin 1 alpha	Homo sapiens	59-82	
12594868-6	2001	High alcohol concentrations exert an immunosuppressive effect on production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1.	Alcohols	5-12	interleukin 1 alpha	Homo sapiens	139-152	
1995437-9	1991	These data suggest that tumor necrosis factor-alpha and interleukin-1 alpha are related to some of the metabolic consequences of both acute and chronic alcohol-induced liver disease, whereas interleukin-6 is related to abnormalities seen in acute liver injury.	Alcohols	152-159	interleukin 1 alpha	Homo sapiens	56-75	
33245573-8	2020	Serum levels of uric acid (UA), a Signal 2 molecule in inflammasome activation, were positively correlated with serum levels of IL-1beta in alcohol use disorder patients with ALD and were increased in Camp-/- mice fed alcohol.	Alcohols	140-147	interleukin 1 alpha	Homo sapiens	128-136	
34827151-6	2021	Conditioned macrophages with serum obtained after four-week intervention with alcohol-free beer significantly reduced the transcription of pro-inflammatory interleukins such as IL-1beta and TNF.	Alcohols	78-85	interleukin 1 alpha	Homo sapiens	177-185	
35335908-4	2022	The biochemical analysis indicated that either alcohol or ATOR or together in combination produced a significant increase in the nucleotide-binding domain-like receptor 3 (NLRP3), interleukin-1beta (IL-1beta) miRNA155 expression levels in the frontal cortex of the brain tissue.	Alcohols	47-54	interleukin 1 alpha	Homo sapiens	199-207