PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21955045-0 2012 Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice. Alcohols 100-107 myeloid differentiation primary response gene 88 Mus musculus 20-25 21955045-2 2012 The aim of the current study was to determine whether TLR4-MyD88-dependent signalling is involved in the acute behavioural actions of alcohol and if alcohol can activate TLR4-downstream MAPK and NF-kappaB pathways. Alcohols 134-141 myeloid differentiation primary response gene 88 Mus musculus 59-64 18792393-4 2008 Alcohol feeding resulted in a significant increase in serum alanine aminotransferase levels, liver steatosis and triglyceride levels suggesting liver damage in WT, TLR2-KO, and MyD88-KO but not in TLR4-KO mice. Alcohols 0-7 myeloid differentiation primary response gene 88 Mus musculus 177-182 18792393-5 2008 Expression of inflammatory mediators (tumor necrosis factor-alpha and interleukin-6) and TLR4 coreceptors (CD14 and MD2) was significantly higher in livers of alcohol-fed WT, TLR2-KO, or MyD88-KO, but not in TLR4-KO mice, compared to controls. Alcohols 159-166 myeloid differentiation primary response gene 88 Mus musculus 187-192 18792393-10 2008 Alcohol feeding also induced nuclear factor-kappaB activation in a TLR4-dependent MyD88-independent manner. Alcohols 0-7 myeloid differentiation primary response gene 88 Mus musculus 82-87 25542736-0 2015 Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling. Alcohols 0-7 myeloid differentiation primary response gene 88 Mus musculus 135-140 25542736-4 2015 Alcohol induced significant LORR in wild-type mice; this was halved by MyD88 and TLR4 deficiency, and surprisingly nearly completely eliminated by TLR2 deficiency. Alcohols 0-7 myeloid differentiation primary response gene 88 Mus musculus 71-76 25542736-5 2015 In contrast, the interaction between morphine and alcohol was found to be MOR-, NF-kappaB-, TLR2- and MyD88-dependent, but did not involve TLR4 or Interleukin-1beta. Alcohols 50-57 myeloid differentiation primary response gene 88 Mus musculus 102-107 21955045-9 2012 CONCLUSIONS AND IMPLICATIONS: These data provide new evidence that TLR4-MyD88 signalling is involved in the acute behavioural actions of alcohol in mice. Alcohols 137-144 myeloid differentiation primary response gene 88 Mus musculus 72-77 21955082-0 2012 TLR4-MyD88 signalling: a molecular target for alcohol actions. Alcohols 46-53 myeloid differentiation primary response gene 88 Mus musculus 5-10 21955082-2 2012 The work reported by Wu et al., in this issue of the British Journal of Pharmacology, indicates that TLR4 along with its intracellular adaptor protein, MyD88, may play crucial roles in the acute actions of alcohol. Alcohols 206-213 myeloid differentiation primary response gene 88 Mus musculus 152-157 21955082-3 2012 The deletions of TLR4 or MyD88 gene or pharmacological inhibition of TLR4 by (+)-naloxone were able to attenuate alcohol-induced sedation, motor impairment and acute alcohol-induced increases in IkBalpha protein levels in the hippocampus of mice. Alcohols 113-120 myeloid differentiation primary response gene 88 Mus musculus 25-30 21955082-3 2012 The deletions of TLR4 or MyD88 gene or pharmacological inhibition of TLR4 by (+)-naloxone were able to attenuate alcohol-induced sedation, motor impairment and acute alcohol-induced increases in IkBalpha protein levels in the hippocampus of mice. Alcohols 166-173 myeloid differentiation primary response gene 88 Mus musculus 25-30 21955082-4 2012 These results clearly suggest that TLR4-MyD88 signalling may play a causal role in the mediation of the behavioural effects of acute alcohol. Alcohols 133-140 myeloid differentiation primary response gene 88 Mus musculus 40-45 35023943-0 2022 CD73 Attenuates Alcohol-Induced Liver Injury and Inflammation via Blocking TLR4/MyD88/NF-kappaB Signaling Pathway. Alcohols 16-23 myeloid differentiation primary response gene 88 Mus musculus 80-85 32604471-9 2021 Acute functional tolerance (AFT) to alcohol-induced ataxia was decreased in Tlr3 -/- mice but was increased in Myd88 -/- mice. Alcohols 36-43 myeloid differentiation primary response gene 88 Mus musculus 111-116 32604471-10 2021 Thus, MyD88 and TLR3 pathways coordinately regulate alcohol consumption and tolerance to intoxicating doses of alcohol and GABAergic drugs. Alcohols 52-59 myeloid differentiation primary response gene 88 Mus musculus 6-11 32604471-10 2021 Thus, MyD88 and TLR3 pathways coordinately regulate alcohol consumption and tolerance to intoxicating doses of alcohol and GABAergic drugs. Alcohols 111-118 myeloid differentiation primary response gene 88 Mus musculus 6-11 30550930-8 2019 Decreased levels of MyD88-dependent pathway correlated with decreased alcohol intake and increased levels of TRIF-dependent pathway correlated with increased alcohol intake in females. Alcohols 70-77 myeloid differentiation primary response gene 88 Mus musculus 20-25 30550931-11 2019 MyD88 null mutants showed poly(I:C)-induced increases in alcohol intake. Alcohols 57-64 myeloid differentiation primary response gene 88 Mus musculus 0-5 27627966-5 2016 Additional experiment showed that hepatic MyD88 was elevated in alcohol-treated Tlr4-wild-type mice but not in Tlr4-mutant mice. Alcohols 64-71 myeloid differentiation primary response gene 88 Mus musculus 42-47 25930080-10 2015 In a chronic-binge ethanol-feeding model, the TLR2 and TLR9-dependent MyD88-dependent pathway mediates CXCL1 production in hepatocytes and HSCs; the CXCL1 then promotes neutrophil infiltration into the liver via CXCR2, resulting in the development of alcohol-mediated liver injury. Alcohols 251-258 myeloid differentiation primary response gene 88 Mus musculus 70-75 23969550-6 2013 Expression of MyD88 was only found to be significantly induced in livers of female alcohol-exposed mice, whereas protein levels of ApoB were found to be significantly lower only in livers of female mice exposed to ethanol. Alcohols 83-90 myeloid differentiation primary response gene 88 Mus musculus 14-19