PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19317851-3	2009	Given that activation of the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade by NMDA receptors is required for various forms of learning and memory, as well as LTP, in hippocampal regions, including the DG, we hypothesized that fetal alcohol-exposed adult animals would have deficits in hippocampal NMDA receptor-dependent ERK1/2 activation.	Alcohols	255-262	mitogen-activated protein kinase 3	Mus musculus	29-70	
19317851-3	2009	Given that activation of the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade by NMDA receptors is required for various forms of learning and memory, as well as LTP, in hippocampal regions, including the DG, we hypothesized that fetal alcohol-exposed adult animals would have deficits in hippocampal NMDA receptor-dependent ERK1/2 activation.	Alcohols	255-262	mitogen-activated protein kinase 3	Mus musculus	72-78	
19317851-4	2009	We used immunoblotting and immunohistochemistry techniques to detect NMDA-stimulated ERK1/2 activation in acute hippocampal slices prepared from adult fetal alcohol-exposed mice.	Alcohols	157-164	mitogen-activated protein kinase 3	Mus musculus	85-91	
19317851-5	2009	We present the first evidence linking prenatal alcohol exposure to deficits in NMDA receptor-dependent ERK1/2 activation specifically in the DG of adult offspring.	Alcohols	47-54	mitogen-activated protein kinase 3	Mus musculus	103-109	
15603755-7	2005	CYP2E1 is induced by alcohol and the primary P450 that carries out ethanol oxidation that can lead to the production of activated oxygen species and oxidative stress that elevate ERK1/2 phosphorylation through EGRF/c-Raf signaling.	Alcohols	21-28	mitogen-activated protein kinase 3	Mus musculus	179-185	
18317950-0	2008	Differential phosphorylation of translation initiation regulators 4EBP1, S6k1, and Erk 1/2 following inhibition of alcohol metabolism in mouse heart.	Alcohols	115-122	mitogen-activated protein kinase 3	Mus musculus	83-90	
18317950-3	2008	Phosphorylation of 4E-BP1, S6k1(Thr(389)), and Erk 1/2 was reduced 2 h following IP injection of alcohol.	Alcohols	97-104	mitogen-activated protein kinase 3	Mus musculus	47-54	
35444406-9	2022	At the same time, we found that alcohol feeding promoted the phosphorylation of EGFR and ERK1/2, both of which were effectively inhibited by suramin (20 mg/kg).	Alcohols	32-39	mitogen-activated protein kinase 3	Mus musculus	89-95	
35444406-10	2022	In vitro, suramin or P2Y2R silencing effectively inhibited the phosphorylation of EGFR and ERK1/2, similar to the down-regulated effects of their corresponding inhibitors (EGFR inhibitor AG1478 and ERK1/2 inhibitor U0126) accompanied by reduced levels of TNF-alpha and IL-1beta compared to alcohol-induced AML-12 cell.	Alcohols	290-297	mitogen-activated protein kinase 3	Mus musculus	91-97	
32535704-8	2020	Alcohol-fed group had 2.6-fold increase in miR-214 and significant decrease in Bcl-2 expression, along with enhanced phosphorylation of ERK1/2 and cleavage of PARP (marker of apoptotic DNA damage) in the heart.	Alcohols	0-7	mitogen-activated protein kinase 3	Mus musculus	136-142	
33220923-8	2021	Alcohol consumption increased expression of the proliferation marker cyclin D1 and activated the p44/42 MAPK (Erk1/2) signaling pathway in small intestinal epithelial cells.	Alcohols	0-7	mitogen-activated protein kinase 3	Mus musculus	110-116	
32535704-9	2020	Co-ingestion with sildenafil blunted the alcohol-induced increase in miR-214, ERK1/2 phosphorylation, and maintained Bcl-2 and decreased PARP cleavage levels.	Alcohols	41-48	mitogen-activated protein kinase 3	Mus musculus	78-84	
30445307-9	2019	Collectively, P2X7R blockade mitigates alcohol-induced steatohepatitis and intestinal injury by inhibiting MEK1/2-ERK1/2 signaling and egr-1 expression.	Alcohols	39-46	mitogen-activated protein kinase 3	Mus musculus	114-120	
25703719-0	2015	Alcohol alters the activation of ERK1/2, a functional regulator of binge alcohol drinking in adult C57BL/6J mice.	Alcohols	0-7	mitogen-activated protein kinase 3	Mus musculus	33-39	
25703719-0	2015	Alcohol alters the activation of ERK1/2, a functional regulator of binge alcohol drinking in adult C57BL/6J mice.	Alcohols	73-80	mitogen-activated protein kinase 3	Mus musculus	33-39	
25703719-11	2015	CONCLUSIONS: These findings indicate that ERK1/2 MAPK signaling regulates binge-like alcohol drinking.	Alcohols	85-92	mitogen-activated protein kinase 3	Mus musculus	42-48	
30445307-0	2019	Purinergic P2X7 receptor blockade mitigates alcohol-induced steatohepatitis and intestinal injury by regulating MEK1/2-ERK1/2 signaling and egr-1 activity.	Alcohols	44-51	mitogen-activated protein kinase 3	Mus musculus	119-125	
30445307-8	2019	Furthermore, P2X7R blockade inhibited MEK1/2-ERK1/2 phosphorylation and egr-1 expression in both liver and intestine from alcohol-fed mice.	Alcohols	122-129	mitogen-activated protein kinase 3	Mus musculus	45-51	
28784931-11	2017	Alcohol disrupted lipopolysaccharide (LPS)-TLR4-ERK1/2-cyclin D1 signaling and inhibited upregulation of Sca-1 and C/EBPbeta expression by lineage-negative marrow cells in response to bacteremia.	Alcohols	0-7	mitogen-activated protein kinase 3	Mus musculus	48-54	
26392309-10	2015	These data indicated that ERK1/2 signaling played an important role in mediating alcohol induced over-expression of GATA4 and MEF2c, which is possibly through the up-regulation of acetylation of histone3 near the gene promoters that affects the expression of GATA4 and MEF2c in H9c2 cells.	Alcohols	81-88	mitogen-activated protein kinase 3	Mus musculus	26-32	
25853264-5	2015	Molecular analysis showed that in utero alcohol exposure induced upregulation of ERalpha signaling and activation of Akt and Erk1/2 in pubertal mammary glands.	Alcohols	40-47	mitogen-activated protein kinase 3	Mus musculus	125-131