PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33357049-2	2021	Phthalates are known endocrine disruptors and oxidant stressors, and exposure has been associated with premature birth, asthma, obesity, insulin resistance and endometriosis.	phthalic acid	0-10	insulin	Homo sapiens	137-144	
12623203-8	2003	The flux enhancement of insulin in the presence of phthalate buffer was higher in comparison to citrate buffer, but the enhancement in these two buffers was the same in the presence of 0.05 M NaCl, which was also supported by a similar trend in conductivity values.	phthalic acid	51-60	insulin	Homo sapiens	24-31	
34562484-5	2022	Effects of phthalate exposure on insulin resistance were also evaluated by systematic review.	phthalic acid	11-20	insulin	Homo sapiens	33-40	
34988825-5	2022	A positive correlation was found between mEP and mBP and HOMA-IR and C-peptide.Phthalate toxicity is considered as one of the risk factors that contributed to insulin resistance and development of T2DM via increasing the levels of HOMA-IR and C-peptide.This will result in the risk of phthalate exposure for diabetogensis and its economic cost for treatment lifetime.	phthalic acid	79-88	insulin	Homo sapiens	159-166	
34498187-0	2021	Association between phthalate exposure and insulin resistance: a systematic review and meta-analysis update.	phthalic acid	20-29	insulin	Homo sapiens	43-50	
34498187-1	2021	An update on systematic review and meta-analysis was performed to explore effects of phthalate exposure on insulin resistance.	phthalic acid	85-94	insulin	Homo sapiens	107-114	
34498187-8	2021	The majority of included studies revealed positive relationships of insulin resistance with different phthalate metabolites exposure.	phthalic acid	102-111	insulin	Homo sapiens	68-75	
35635958-0	2022	Relationships among phthalate exposure, oxidative stress, and insulin resistance in young military soldiers: A cumulative risk assessment and mediation approach.	phthalic acid	20-29	insulin	Homo sapiens	62-69	
35635958-1	2022	BACKGROUND: Epidemiological studies concerning whether oxidative stress mediates phthalate exposure-insulin resistance (IR) associations in young adults are limited.	phthalic acid	81-90	insulin	Homo sapiens	100-107	
33995534-9	2021	Furthermore, the crude and adjusted linear regression models indicated the significant association of phthalate metabolites with superoxide dismutase (SOD), malondialdehyde (MDA), and homeostasis model assessment of insulin resistance (HOMA-IR) (p < 0.05).	phthalic acid	102-111	insulin	Homo sapiens	216-223	
31521963-0	2019	Serum beta-carotene modifies the association between phthalate mixtures and insulin resistance: The National Health and Nutrition Examination Survey 2003-2006.	phthalic acid	53-62	insulin	Homo sapiens	76-83	
32481506-4	2020	Epidemiological studies show a statistical link between exposure to pesticides, polychlorinated bisphenyls, bisphenol A, phthalates, aromatic polycyclic hydrocarbides, or dioxins and insulin resistance.	phthalic acid	121-131	insulin	Homo sapiens	183-190	
31808097-9	2020	Combined phthalates influence on glucose and lipid metabolism may increase the possibility for NAFLD and insulin resistance development among exposed individuals.	phthalic acid	9-19	insulin	Homo sapiens	105-112	
32735599-9	2020	As both phthalates/bisphenol and ultra-processed foods have been previously associated with insulin resistance, diabetes, general/abdominal obesity and hypertension, our results suggest the possibility of contact materials in ultra-processed foods as one link between ultra-processed food and these health outcomes.	phthalic acid	8-18	insulin	Homo sapiens	92-99	
31521963-3	2019	We conduct a study to examine associations of urinary concentrations of phthalate metabolites (individually and as a mixture) with insulin resistance, along with potential effect modification by serum antioxidant concentrations.	phthalic acid	72-81	insulin	Homo sapiens	131-138	
28898934-0	2018	The associations between phthalate exposure and insulin resistance, beta-cell function and blood glucose control in a population-based sample.	phthalic acid	25-34	insulin	Homo sapiens	48-55	
30481198-12	2018	Further studies are necessary to elucidate the causal links between altered phthalate metabolism and increased susceptibility to insulin resistance in children.	phthalic acid	76-85	insulin	Homo sapiens	129-136	
31726561-0	2019	Association of urinary phthalate metabolites and phenolics with adipokines and insulin resistance related markers among women of reproductive age.	phthalic acid	23-32	insulin	Homo sapiens	79-86	
31726561-13	2019	Our observations show that among many consumer chemicals, phthalates may affect serum adipokines, and thus glucose, and insulin resistance in adult females.	phthalic acid	58-68	insulin	Homo sapiens	120-127	
31158561-0	2019	Changes in insulin resistance mediate the associations between phthalate exposure and metabolic syndrome.	phthalic acid	63-72	insulin	Homo sapiens	11-18	
31158561-7	2019	Mediation analysis was conducted to assess the role of insulin resistance in the associations between phthalate exposure and MetS.	phthalic acid	102-111	insulin	Homo sapiens	55-62	
30703729-0	2019	Associations of phthalate exposure with lipid levels and insulin sensitivity index in children: A prospective cohort study.	phthalic acid	16-25	insulin	Homo sapiens	57-64	
30703729-9	2019	Our findings suggest that phthalate exposure during childhood is association with effects in terms of insulin-sensitivity index.	phthalic acid	26-35	insulin	Homo sapiens	102-109	
28898934-3	2018	To test associations between phthalate exposures, estimated from urinary phthalate metabolites, and insulin resistance, beta-cell function and glucose control.	phthalic acid	29-38	insulin	Homo sapiens	100-107	
28359975-1	2017	Phthalates are commonly used as plasticizers and are reported to associate with testicular dysfunction or insulin resistance in different studies, but the concurrent relationship between phthalate exposure, testosterone levels, and insulin resistance in the young population is not well understood.	phthalic acid	0-10	insulin	Homo sapiens	106-113	
28099427-8	2017	Each log unit increase of high molecular weight (HMW) phthalate metabolites was associated with a 0.550 increase in Homeostatic Model Assessment of insulin resistance (HOMA-IR) units (P = 0.019) and altered circulating levels of activated endothelial cell-derived microparticles (% per ml) (P = 0.026).	phthalic acid	54-63	insulin	Homo sapiens	148-155	
28099427-11	2017	CONCLUSION: Exposure to bisphenols and phthalates, including a BPA replacement, is associated with increased oxidant stress, insulin resistance, albuminuria, as well as disturbances in vascular function in healthy children.	phthalic acid	39-49	insulin	Homo sapiens	125-132	
25993640-2	2015	Phthalate exposures, in particular DEHP, have been associated with insulin resistance in adolescents, but there are no data regarding the two substitutes, DINP and DIDP.	phthalic acid	0-9	insulin	Homo sapiens	67-74	
23958772-2	2013	Phthalate exposures, in particular to DEHP, have been associated with insulin resistance in adults, but have not been studied in adolescents.	phthalic acid	0-9	insulin	Homo sapiens	70-77	
22796563-10	2012	Certain phthalate metabolites were positively associated with FBG and insulin resistance.	phthalic acid	8-17	insulin	Homo sapiens	70-77	
17589594-0	2007	Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males.	phthalic acid	26-35	insulin	Homo sapiens	102-109	
25622280-0	2015	Urinary phthalate metabolites are associated with insulin resistance in obese subjects.	phthalic acid	8-17	insulin	Homo sapiens	50-57