PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12163452-8	2002	Supplementation with tetrahydrobiopterin, an NOS cofactor, reduced the atherosclerotic lesion size in apoE-KO/eNOS-Tg mice to the level comparable to apoE-KO mice, possibly through the improvement of eNOS dysfunction.	sapropterin	21-40	apolipoprotein E	Mus musculus	102-106	
32924886-11	2021	A neopterin derivative tetrahydroneopterin (BH4), also known as a cofactor for nitric oxide (NO) synthases, suppresses atherosclerosis and vascular injury-induced neointimal hyperplasia in Apoe-/- mice.	sapropterin	44-47	apolipoprotein E	Mus musculus	189-193	
30847343-7	2019	In addition, aortic nitrate as a marker of nitric oxide activity and the endothelial nitric oxide synthase (eNOS) co-factor, tetrahydrobiopterin (BH4) were reduced in BDKRB2-expressing ApoE-deficient mice.	sapropterin	125-144	apolipoprotein E	Mus musculus	185-189	
30847343-9	2019	In agreement with a causal involvement of decreased BH4 levels in the atherogenic function of BDKRB2, we found that treatment with the BH4 analog, sapropterin, significantly retarded atherosclerotic plaque formation in BDKRB2-expressing ApoE-deficient mice.	sapropterin	135-138	apolipoprotein E	Mus musculus	237-241	
30847343-9	2019	In agreement with a causal involvement of decreased BH4 levels in the atherogenic function of BDKRB2, we found that treatment with the BH4 analog, sapropterin, significantly retarded atherosclerotic plaque formation in BDKRB2-expressing ApoE-deficient mice.	sapropterin	147-158	apolipoprotein E	Mus musculus	237-241	
30091833-7	2018	In vivo, nicotine induced endothelial dysfunction and promoted atherosclerosis in ApoE-/- mice, which were attenuated by GTPCH1 overexpression or BH4 supplement.	sapropterin	146-149	apolipoprotein E	Mus musculus	82-86	
22715945-6	2013	Furthermore, HDMPPA treatment in apoE KO mice inhibited eNOS uncoupling through an increase in vascular tetrahydrobiopterin content and a decrease in serum asymmetric dimethylarginine levels.	sapropterin	104-123	apolipoprotein E	Mus musculus	33-37	
17463333-7	2007	GCH overexpression in ApoE-KO/eNOS-Tg/GCH-Tg mice increased vascular BH4 levels and reduced plaque area.	sapropterin	69-72	apolipoprotein E	Mus musculus	22-26	
17463333-10	2007	CONCLUSION: In contrast to vitamin C treatment, augmenting BH4 levels in the endothelium by GCH overexpression reduced the accelerated atherosclerotic lesion formation in ApoE-KO/eNOS-Tg mice, associated with a reduction of superoxide production from uncoupled eNOS.	sapropterin	59-62	apolipoprotein E	Mus musculus	171-175	
14707037-0	2004	Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.	sapropterin	22-41	apolipoprotein E	Mus musculus	166-170	
14707037-5	2004	Compared with ApoE-KO controls, transgenic mice (ApoE-KO/GCH-Tg) had higher aortic BH4 levels, reduced endothelial superoxide production and eNOS uncoupling, increased cGMP levels, and preserved NO-mediated endothelium dependent vasorelaxations.	sapropterin	83-86	apolipoprotein E	Mus musculus	49-53	
20337596-0	2010	Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.	sapropterin	0-19	apolipoprotein E	Mus musculus	89-105	
17272747-0	2007	Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice.	sapropterin	23-42	apolipoprotein E	Mus musculus	87-103	
17272747-2	2007	METHODS AND RESULTS: In this study, we investigated whether oral BH4 treatment might slow the progression of atherosclerosis using hypercholesterolemic apolipoprotein E-knockout mice.	sapropterin	65-68	apolipoprotein E	Mus musculus	152-168	
17272747-4	2007	Furthermore, we report that BH4 treatment improves endothelial dysfunction and attenuates increased mRNA expression of NADPH oxidase components, as well as a number of inflammatory factors, such as LOX-1 and MCP-1, in the aortas of apolipoprotein E- knockout mice.	sapropterin	28-31	apolipoprotein E	Mus musculus	232-248	
12522125-6	2003	Significantly higher tetrahydrobiopterin levels were detected in aortas of apoE-deficient mice.	sapropterin	21-40	apolipoprotein E	Mus musculus	75-79	
12522125-8	2003	In addition, 7,8-dihydrobiopterin levels, an oxidized form of tetrahydrobiopterin, were decreased and vascular endothelial function of aortas was significantly improved in apoE-deficient mice.	sapropterin	62-81	apolipoprotein E	Mus musculus	172-176