PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20139904-5 2010 In addition, AG1478, 1,10-phenanthroline, and CRM197 also inhibited the tyrosine phosphorylation of EGF-R and ERK1/2 that was induced by 14,15-EET in the A549, HepG2, and MDA-MB-231 cell lines. 14,15-epoxy-5,8,11-eicosatrienoic acid 137-146 mitogen-activated protein kinase 3 Homo sapiens 110-116 23283969-7 2013 These studies (a) identify an ERK1/2-dependent mechanism for ENaC inhibition by 14,15-EET, (b) point to ENaC as a proximal target for EET-activated ERK1/2 mitogenic kinases, (c) characterize a mechanistic commonality between EGF and epoxygenase metabolites as ENaC inhibitors, and (d) suggest a CYP2C epoxygenase-mediated pathway for the regulation of distal sodium transport. 14,15-epoxy-5,8,11-eicosatrienoic acid 80-89 mitogen-activated protein kinase 3 Homo sapiens 30-36