PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23869778-1	2014	The expression of CYP27B1 or vitamin D 1alpha-hydroxylase (1alpha-OHase) and CYP24A1 in specific tissues may act as the central part between 25-hydroxyvitamin D [25(OH)D] serum levels and the anticancer effects of1alpha,25-dihydroxyvitamin D [1alpha,25(OH)2D3],alternative splicing of these enzymes may affect their biological functions.	25(oh)2d3	250-259	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	18-25	
28218743-2	2017	Vitamin D is activated through hydroxylation by 25-hydroxylases (CYP2R1 or CYP27A1) and 1alpha-hydroxylase (CYP27B1) to produce 1,25(OH)2D3, or through the action of CYP11A1 to produce mono-di- and trihydroxy-D3 products that can be further modified by CYP27B1, CYP27A1, and CYP24A1.	25(oh)2d3	130-139	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	108-115	
26124321-3	2015	The aim of the present study was to elucidate the role of 1alpha,25(OH)2D3 production by 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1) on prostate cancer cell growth.	25(oh)2d3	65-74	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	129-136	
24461581-5	2014	RESULTS: Here we show that mouse and human mast cells can convert 25OHD3 to 1alpha,25(OH)2D3 through CYP27B1 activity and that both of these vitamin D3 metabolites suppressed IgE-induced mast cell-derived proinflammatory and vasodilatory mediator production in a VDR-dependent manner in vitro.	25(oh)2d3	83-92	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	101-108	
24597546-4	2014	24R,25(OH)2D3 inhibited hMSC proliferation, decreased 1alpha-hydroxylase (CYP27B) expression, thereby reducing the ability of hMSCs to convert 25(OH)D3 to 1alpha,25(OH)2D3, and promoted osteoblastic differentiation through increased alkaline phosphatase activity and Ca(2+) mineralization.	25(oh)2d3	4-13	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	74-80	
19667162-10	2009	It can be speculated whether increased expression of CYP27B1 splice variants that lack enzymatic activity (Hyd-V3/V5) may result in a reduction of enzymatic activity and in reduced synthesis of 1,25(OH)2D3.	25(oh)2d3	196-205	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	53-60	
17426122-1	2007	The human 25-hydroxyvitamin D3 (25(OH)D3) 1alpha-hydroxylase, which is encoded by the CYP27B1 gene, catalyzes the metabolic activation of the 25(OH)D3 into 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3), the most biologically potent vitamin D3 metabolite.	25(oh)2d3	194-203	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	86-93	
10612418-3	1999	1Alpha,25(OH)2D3, is biosynthesized from cholesterol, and at the final biosynthesis step, 25-hydroxyvitamin D3 1alpha-hydroxylase [1alpha(OH)ase] in kidney conducts 1alpha-hydroxylation of 25(OH)2D3.	25(oh)2d3	7-16	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	90-129	
10612418-3	1999	1Alpha,25(OH)2D3, is biosynthesized from cholesterol, and at the final biosynthesis step, 25-hydroxyvitamin D3 1alpha-hydroxylase [1alpha(OH)ase] in kidney conducts 1alpha-hydroxylation of 25(OH)2D3.	25(oh)2d3	7-16	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	131-144	
10612418-3	1999	1Alpha,25(OH)2D3, is biosynthesized from cholesterol, and at the final biosynthesis step, 25-hydroxyvitamin D3 1alpha-hydroxylase [1alpha(OH)ase] in kidney conducts 1alpha-hydroxylation of 25(OH)2D3.	25(oh)2d3	189-198	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	90-129	
10612418-3	1999	1Alpha,25(OH)2D3, is biosynthesized from cholesterol, and at the final biosynthesis step, 25-hydroxyvitamin D3 1alpha-hydroxylase [1alpha(OH)ase] in kidney conducts 1alpha-hydroxylation of 25(OH)2D3.	25(oh)2d3	189-198	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	131-144	
31470109-13	2019	Moreover, UV irradiation upregulates the enzyme CYP27B1, which leads to 1alpha,25(OH)2D3 synthesis, but downregulates the cholesterol-producing enzyme DHCR7, both of which collectively lead to increased MMP-1 expression in human keratinocytes.	25(oh)2d3	79-88	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	48-55