PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12920169-7	2003	Contributions of cytochrome p450 (p450) enzymes to NNK oxidation were demonstrated by NADPH dependence, inhibition by carbon monoxide, and inhibition by the nonselective p450 inhibitors proadifen hydrochloride (SKF-525A) and 1-aminobenzotriazole (ABT), particularly in lung microsomes from high bioactivators.	Proadifen	186-209	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	28-32	
18799803-3	2008	SKF525A and its metabolite and primary amine analog all inhibited CYP2B6-, CYP2C9-, CYP2C19-, CYP2D6-, and CYP3A-selective reactions to varying degrees but had little effect on CYP1A2, CYP2A6, and CYP2E1 reactions.	Proadifen	0-7	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	66-72	
12920169-7	2003	Contributions of cytochrome p450 (p450) enzymes to NNK oxidation were demonstrated by NADPH dependence, inhibition by carbon monoxide, and inhibition by the nonselective p450 inhibitors proadifen hydrochloride (SKF-525A) and 1-aminobenzotriazole (ABT), particularly in lung microsomes from high bioactivators.	Proadifen	186-209	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	34-38	
12920169-7	2003	Contributions of cytochrome p450 (p450) enzymes to NNK oxidation were demonstrated by NADPH dependence, inhibition by carbon monoxide, and inhibition by the nonselective p450 inhibitors proadifen hydrochloride (SKF-525A) and 1-aminobenzotriazole (ABT), particularly in lung microsomes from high bioactivators.	Proadifen	186-209	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	34-38	
12920169-7	2003	Contributions of cytochrome p450 (p450) enzymes to NNK oxidation were demonstrated by NADPH dependence, inhibition by carbon monoxide, and inhibition by the nonselective p450 inhibitors proadifen hydrochloride (SKF-525A) and 1-aminobenzotriazole (ABT), particularly in lung microsomes from high bioactivators.	Proadifen	211-219	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	28-32	
12920169-7	2003	Contributions of cytochrome p450 (p450) enzymes to NNK oxidation were demonstrated by NADPH dependence, inhibition by carbon monoxide, and inhibition by the nonselective p450 inhibitors proadifen hydrochloride (SKF-525A) and 1-aminobenzotriazole (ABT), particularly in lung microsomes from high bioactivators.	Proadifen	211-219	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	34-38	
12920169-7	2003	Contributions of cytochrome p450 (p450) enzymes to NNK oxidation were demonstrated by NADPH dependence, inhibition by carbon monoxide, and inhibition by the nonselective p450 inhibitors proadifen hydrochloride (SKF-525A) and 1-aminobenzotriazole (ABT), particularly in lung microsomes from high bioactivators.	Proadifen	211-219	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	34-38	
2856164-8	1988	The RA metabolism in rat epidermal microsomes shows the typical characteristics of a cytochrome-P-450 (P450)-dependent enzyme system, i.e. a requirement for NADPH and oxygen and inhibition by CO and SKF-525A.	Proadifen	199-207	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	103-107	
8968067-11	1996	SKF525A, an isozyme non-selective P450 inhibitor, enhanced [3H]AFB1 binding to cellular DNA in unseparated cells, macrophages, and type II cells, suggesting that P450-mediated bioactivation of AFB1 is not a major pathway by which AFB1-8,9-epoxide is formed in human lung cells.	Proadifen	0-7	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	34-38	
8968067-11	1996	SKF525A, an isozyme non-selective P450 inhibitor, enhanced [3H]AFB1 binding to cellular DNA in unseparated cells, macrophages, and type II cells, suggesting that P450-mediated bioactivation of AFB1 is not a major pathway by which AFB1-8,9-epoxide is formed in human lung cells.	Proadifen	0-7	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	162-166	
8819299-7	1996	SKF-525A inhibited > 40% of the metabolic activity of all substrates tested, and the inhibitory effects differed among P450 forms.	Proadifen	0-8	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	122-126	
28369648-9	2017	The P450 inhibitor SKF525A partly negated the protective effect of astrocytes, allowing reduction in branch points with chlorpyrifos (10 muM).	Proadifen	19-26	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	4-8	
28866862-5	2017	SKF-525A, a widely used non-specific P450 inhibitor, had no inhibitory activity against CYP1A2, 2A6, 2E1 and 2J2, while it showed an inhibitory effect against CYP2B6, CYP2C19 and 2D6 with IC50 values of 2.5, 3.6 and 0.5 mu m, respectively.	Proadifen	0-8	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	159-165