PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32485858-0 2020 Javamide-II Inhibits IL-6 without Significant Impact on TNF-alpha and IL-1beta in Macrophage-Like Cells. javamide-ii 0-11 interleukin 6 Homo sapiens 21-25 32485858-2 2020 In this study, the potential effects of javamide-II on IL-6, IL-1beta and TNF-alpha productions were determined using their ELISA kits in macrophage-like THP-1 cells. javamide-ii 40-51 interleukin 6 Homo sapiens 55-59 32485858-4 2020 At concentrations of 0.2-40 microM, javamide-II inhibited IL-6 production significantly in the THP-1 cells (IC50 of 0.8 microM) (P < 0.02). javamide-ii 36-47 interleukin 6 Homo sapiens 58-62 32485858-8 2020 The data indicate that javamide-II may be a potent compound to inhibit IL-6 production via suppressing the p38 signal pathway, without significant effects on the productions of TNF-alpha and IL-1beta in macrophage-like THP-1 cells. javamide-ii 23-34 interleukin 6 Homo sapiens 71-75