PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23942851-0	2013	High concentrations of pyridoxal stimulate the expression of IGFBP1 in HepG2 cells through upregulation of the ERK/c-Jun pathway.	Pyridoxal	23-32	insulin like growth factor binding protein 1	Homo sapiens	61-67	
23942851-3	2013	Preliminary results in the current study indicated, following DNA microarray analysis and quantitative PCR, that insulin-like growth factor-binding protein 1 (IGFBP1) mRNA is upregulated in HT29 colon carcinoma cells exposed to pyridoxal (PL, 500 microM).	Pyridoxal	228-237	insulin like growth factor binding protein 1	Homo sapiens	113-157	
23942851-3	2013	Preliminary results in the current study indicated, following DNA microarray analysis and quantitative PCR, that insulin-like growth factor-binding protein 1 (IGFBP1) mRNA is upregulated in HT29 colon carcinoma cells exposed to pyridoxal (PL, 500 microM).	Pyridoxal	228-237	insulin like growth factor binding protein 1	Homo sapiens	159-165	
23942851-3	2013	Preliminary results in the current study indicated, following DNA microarray analysis and quantitative PCR, that insulin-like growth factor-binding protein 1 (IGFBP1) mRNA is upregulated in HT29 colon carcinoma cells exposed to pyridoxal (PL, 500 microM).	Pyridoxal	239-241	insulin like growth factor binding protein 1	Homo sapiens	113-157	
23942851-3	2013	Preliminary results in the current study indicated, following DNA microarray analysis and quantitative PCR, that insulin-like growth factor-binding protein 1 (IGFBP1) mRNA is upregulated in HT29 colon carcinoma cells exposed to pyridoxal (PL, 500 microM).	Pyridoxal	239-241	insulin like growth factor binding protein 1	Homo sapiens	159-165	
23942851-5	2013	Thus, further experiments were performed to investigate the effect of PL on the expression of IGFBP1 in HepG2 hepatocellular carcinoma cells.	Pyridoxal	70-72	insulin like growth factor binding protein 1	Homo sapiens	94-100	
23942851-6	2013	The addition of PL (500 microM) markedly increased the expression of IGFBP1 mRNA in HepG2 cells at 6, 12 and 24 h (P<0.01), whereas other vitamers (500 microM), including pyridoxal 5"-phosphate (PLP), pyridoxine (PN) and pyridoxamine (PM), caused no such effect.	Pyridoxal	16-18	insulin like growth factor binding protein 1	Homo sapiens	69-75	
23942851-10	2013	Higher expression of IGFBP1 protein by PL was suppressed by cycloheximide.	Pyridoxal	39-41	insulin like growth factor binding protein 1	Homo sapiens	21-27	
23942851-11	2013	These results suggest that PL may induce the expression of IGFBP1 in hepatoma cells via a mechanism involving the ERK/c-Jun pathway.	Pyridoxal	27-29	insulin like growth factor binding protein 1	Homo sapiens	59-65