PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34023785-4 2021 By using a metabolite library screen, we showed that pyridoxal (PL) significantly suppresses PD-L1 expression. Pyridoxal 53-62 CD274 molecule Sus scrofa 93-98 34023785-4 2021 By using a metabolite library screen, we showed that pyridoxal (PL) significantly suppresses PD-L1 expression. Pyridoxal 64-66 CD274 molecule Sus scrofa 93-98 34023785-6 2021 Functionally, PL enhances T cell killing activity by blocking the PD-1/PD-L1 signaling pathway. Pyridoxal 14-16 CD274 molecule Sus scrofa 71-76 34023785-7 2021 Thus, we have identified PL as an inhibitor of PD-L1, which provides a feasible option for combination immunotherapy. Pyridoxal 25-27 CD274 molecule Sus scrofa 47-52