PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32966970-4	2020	ACE2 is an established component of the "protective arm" of the renin-angiotensin-aldosterone-system (RAAS) that opposes ACE/angiotensin II (ANG II) pressor and tissue remodelling actions.	Angiotensin II	141-147	angiotensin converting enzyme 2	Homo sapiens	0-4	
32507883-4	2020	We believe that exaggerated activation of ACE/Angiotensin II (Ang II)/Angiotensin Type 1 (AT1) receptor RAS axis in line with reduction of ACE2/Angiotensin-(1-7)/Mas receptor may exert a pivotal role in the pathogenesis of Covid-19.	Angiotensin II	62-68	angiotensin converting enzyme 2	Homo sapiens	139-143	
31141400-2	2019	Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG II to generate ANG(1-7) peptide, which counteracts the adverse effects of ANG II accumulation.	Angiotensin II	162-168	angiotensin converting enzyme 2	Homo sapiens	37-68	
32582222-2	2020	A common denominator of all affected organs is the expression of angiotensin-converting enzyme 2 (ACE2), a protease responsible for the conversion of Angiotensin 1-8 (Ang II) to Angiotensin 1-7 (Ang 1-7).	Angiotensin II	167-173	angiotensin converting enzyme 2	Homo sapiens	65-96	
32582222-2	2020	A common denominator of all affected organs is the expression of angiotensin-converting enzyme 2 (ACE2), a protease responsible for the conversion of Angiotensin 1-8 (Ang II) to Angiotensin 1-7 (Ang 1-7).	Angiotensin II	167-173	angiotensin converting enzyme 2	Homo sapiens	98-102	
31141400-2	2019	Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG II to generate ANG(1-7) peptide, which counteracts the adverse effects of ANG II accumulation.	Angiotensin II	84-90	angiotensin converting enzyme 2	Homo sapiens	37-68	
31141400-2	2019	Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG II to generate ANG(1-7) peptide, which counteracts the adverse effects of ANG II accumulation.	Angiotensin II	84-90	angiotensin converting enzyme 2	Homo sapiens	70-74	
31141400-2	2019	Within the renin-angiotensin system, angiotensin-converting enzyme 2 (ACE2) cleaves ANG II to generate ANG(1-7) peptide, which counteracts the adverse effects of ANG II accumulation.	Angiotensin II	162-168	angiotensin converting enzyme 2	Homo sapiens	70-74	
34806090-3	2021	The binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) leads to deregulation of the renin-angiotensin-aldosterone system (RAAS) through down-regulation of ACE2 with subsequent increment of the harmful Ang II serum levels and reduction of the protective Ang-(1-7).	Angiotensin II	218-224	angiotensin converting enzyme 2	Homo sapiens	33-64	
32362932-1	2012	Angiotensin converting enzyme 2 (ACE2), is a monocarboxypeptidase which metabolizes several peptides including the degradation of Ang II, a peptide with vasoconstrictive/proliferative/effects, to generate Ang 1-7, which acting through its receptor Mas exerts vasodilatory/anti-proliferative actions.	Angiotensin II	130-136	angiotensin converting enzyme 2	Homo sapiens	0-31	
32362932-1	2012	Angiotensin converting enzyme 2 (ACE2), is a monocarboxypeptidase which metabolizes several peptides including the degradation of Ang II, a peptide with vasoconstrictive/proliferative/effects, to generate Ang 1-7, which acting through its receptor Mas exerts vasodilatory/anti-proliferative actions.	Angiotensin II	130-136	angiotensin converting enzyme 2	Homo sapiens	33-37	
32362932-6	2012	Human recombinant ACE2 has been safely administered to healthy human volunteers intravenously resulting in sustained lowering of plasma Ang II levels.	Angiotensin II	136-142	angiotensin converting enzyme 2	Homo sapiens	18-22	
34806090-3	2021	The binding of SARS-CoV-2 to the angiotensin-converting enzyme 2 (ACE2) leads to deregulation of the renin-angiotensin-aldosterone system (RAAS) through down-regulation of ACE2 with subsequent increment of the harmful Ang II serum levels and reduction of the protective Ang-(1-7).	Angiotensin II	218-224	angiotensin converting enzyme 2	Homo sapiens	66-70	
35408447-1	2022	The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its downregulation, which subsequently leads to the dysregulation of the renin-angiotensin system (RAS) in favor of the ACE-angiotensin II (Ang II)-angiotensin II type I receptor (AT1R) axis.	Angiotensin II	316-322	angiotensin converting enzyme 2	Homo sapiens	129-160	
34530706-3	2021	The principal activity of ACE2 is to metabolize Ang II into the vasodilatory Ang-(1-7).	Angiotensin II	48-54	angiotensin converting enzyme 2	Homo sapiens	26-30	
35549373-6	2022	ACE2 is one of the main enzymes responsible for dampening the primary effector peptide Ang II (angiotensin II), metabolizing it to Ang-(1-7).	Angiotensin II	87-93	angiotensin converting enzyme 2	Homo sapiens	0-4	
35408447-1	2022	The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its downregulation, which subsequently leads to the dysregulation of the renin-angiotensin system (RAS) in favor of the ACE-angiotensin II (Ang II)-angiotensin II type I receptor (AT1R) axis.	Angiotensin II	316-322	angiotensin converting enzyme 2	Homo sapiens	162-166