PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25449421-3 2015 IGFBP-3 and the PPARgamma ligands, rosiglitazone or 15-deoxy-Delta(12,14)-prostaglandin J2, separately inhibited the proliferation of MCF-7, MDA-MB-231 and MDA-MB-468 breast cancer cells. 15-deoxy-delta 52-66 peroxisome proliferator activated receptor gamma Homo sapiens 16-25 24337644-1 2014 A well-recognized natural ligand of PPARgamma, 15-deoxy-delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) possesses immunomodulatory properties. 15-deoxy-delta 47-61 peroxisome proliferator activated receptor gamma Homo sapiens 36-45 21236332-2 2011 15-Deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)), a metabolite of PGD(2) and PPARgamma-ligand, exerts a panel of biological activities via receptor-dependent and -independent mechanisms. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 70-79 22991494-2 2012 The aim was to investigate the cytotoxicity and action mechanisms of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), one of endogenous ligands for PPARgamma, in terms of PPARgamma-dependency and the mitogen-activated protein kinase (MAPK) and Akt pathway in three human renal cell carcinoma (RCC)-derived cell lines. 15-deoxy-delta 69-83 peroxisome proliferator activated receptor gamma Homo sapiens 154-163 22991494-2 2012 The aim was to investigate the cytotoxicity and action mechanisms of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), one of endogenous ligands for PPARgamma, in terms of PPARgamma-dependency and the mitogen-activated protein kinase (MAPK) and Akt pathway in three human renal cell carcinoma (RCC)-derived cell lines. 15-deoxy-delta 69-83 peroxisome proliferator activated receptor gamma Homo sapiens 177-186 22469179-4 2012 BALB/c (H-2(d)) islets in which PPARgamma activity was induced by its agonists, 15-deoxy-Delta(12-14)-prostaglandin J(2) (15d-PGJ(2)) or troglitazone were transplanted into C57BL/6 (H-2(b)) recipients that had been rendered diabetic by streptozotocin (STZ). 15-deoxy-delta 80-94 peroxisome proliferator activated receptor gamma Homo sapiens 32-41 21683069-3 2011 An endogenous ligand for peroxisome proliferator-activated receptor-gamma (PPARgamma), 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), induces apoptosis in RCC. 15-deoxy-delta 87-101 peroxisome proliferator activated receptor gamma Homo sapiens 25-73 21511917-3 2011 The objective of the present studies was to examine whether 15-deoxy-Delta(12,14)-PGJ(2)-glycerol ester (15d-PGJ(2)-G), a putative metabolite of 2-AG, can mimic the actions of 2-AG on IL-2 regulation through PPARgamma activation. 15-deoxy-delta 60-74 peroxisome proliferator activated receptor gamma Homo sapiens 208-217 20670683-3 2010 For comparison, pravastatin, isosorbide-5-mononitrate (ISMN), sodium nitroprusside (SNP) and the PPARgamma ligand 15-deoxy-Delta(12,14)-prostaglandin J(2) (PGJ) were also tested. 15-deoxy-delta 114-128 peroxisome proliferator activated receptor gamma Homo sapiens 97-106 20843793-4 2010 However, the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2), dose dependently reduced IGF-1R (10 mumol/liter, 80% decrease, n = 4, p < 0.01), and overexpression of PPARgamma using an adenovirus likewise reduced IGF-1R (50% decrease versus SMC infected with control adenovirus), suggesting a PPARgamma-independent action of TZDs. 15-deoxy-delta 42-56 peroxisome proliferator activated receptor gamma Homo sapiens 24-33 20843793-4 2010 However, the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2), dose dependently reduced IGF-1R (10 mumol/liter, 80% decrease, n = 4, p < 0.01), and overexpression of PPARgamma using an adenovirus likewise reduced IGF-1R (50% decrease versus SMC infected with control adenovirus), suggesting a PPARgamma-independent action of TZDs. 15-deoxy-delta 42-56 peroxisome proliferator activated receptor gamma Homo sapiens 190-199 20843793-4 2010 However, the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2), dose dependently reduced IGF-1R (10 mumol/liter, 80% decrease, n = 4, p < 0.01), and overexpression of PPARgamma using an adenovirus likewise reduced IGF-1R (50% decrease versus SMC infected with control adenovirus), suggesting a PPARgamma-independent action of TZDs. 15-deoxy-delta 42-56 peroxisome proliferator activated receptor gamma Homo sapiens 190-199 20036328-11 2010 Expression of AKR1C3 reduced the anti-proliferative effects of PGD(2) on MCF-7 cells, suggesting that AKR1C3 limits peroxisome proliferator activated receptor gamma (PPARgamma) signaling by reducing formation of 15-deoxy-Delta(12,14)-PGJ(2) (15dPGJ(2)). 15-deoxy-delta 212-226 peroxisome proliferator activated receptor gamma Homo sapiens 116-164 20036328-11 2010 Expression of AKR1C3 reduced the anti-proliferative effects of PGD(2) on MCF-7 cells, suggesting that AKR1C3 limits peroxisome proliferator activated receptor gamma (PPARgamma) signaling by reducing formation of 15-deoxy-Delta(12,14)-PGJ(2) (15dPGJ(2)). 15-deoxy-delta 212-226 peroxisome proliferator activated receptor gamma Homo sapiens 166-175 19286977-5 2009 The inhibitory concentration causing a 50% decrease in aSMA for CDDO was 20-fold lower than the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2) (15 d-PGJ(2)), and 400-fold lower than the synthetic ligand, rosiglitazone. 15-deoxy-delta 125-139 peroxisome proliferator activated receptor gamma Homo sapiens 107-116 20438519-1 2010 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is an endogenous peroxisome proliferator-activated receptor gamma (PPARgamma) agonist that suppresses progressive matrix deposition; however, little is known about the effects of 15d-PGJ(2) on human peritoneal mesothelial cells (HPMCs). 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 71-119 20438519-1 2010 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is an endogenous peroxisome proliferator-activated receptor gamma (PPARgamma) agonist that suppresses progressive matrix deposition; however, little is known about the effects of 15d-PGJ(2) on human peritoneal mesothelial cells (HPMCs). 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 121-130 19673929-9 2009 Three different TZDs (ciglitazone, rosiglitazone and troglitazone) and the endogenous PPARgamma ligand 15-deoxy-delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) inhibited CMF proliferation (cell number and expression of proliferating cell nuclear antigen) in a concentration-dependent manner (range 0.1-10 micromol/L) with similar potencies. 15-deoxy-delta 103-117 peroxisome proliferator activated receptor gamma Homo sapiens 86-95 19346435-5 2009 We found that synthetic PPARgamma agonists, rosiglitazone (RGZ) and troglitazone (TGZ), induced proliferation of human bronchial epithelial cells, whereas the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), inhibited cell growth. 15-deoxy-delta 188-202 peroxisome proliferator activated receptor gamma Homo sapiens 24-33 19346435-5 2009 We found that synthetic PPARgamma agonists, rosiglitazone (RGZ) and troglitazone (TGZ), induced proliferation of human bronchial epithelial cells, whereas the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), inhibited cell growth. 15-deoxy-delta 188-202 peroxisome proliferator activated receptor gamma Homo sapiens 170-179 19101554-1 2009 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) activates a nuclear receptor heterodimer, peroxisome proliferators-activated receptor gamma (PPARgamma)/ retinoid X receptor (RXRalpha) through covalent binding to Cys285 in PPARgamma ligand-binding domain (LBD). 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 96-145 19275963-1 2009 A series of analogues of the PPARgamma ligand 15-deoxy-Delta(12,14)-PGJ(2) have been synthesized by functionalization of a 5-alkyl-4-hydroxycyclopentenone core structure obtained by Piancatelli rearrangement of precursor furylcarbinol. 15-deoxy-delta 46-60 peroxisome proliferator activated receptor gamma Homo sapiens 29-38 19018984-3 2009 Recently, we demonstrated that the methylxanthine derivate caffeine leads to an upregulation of peroxisome proliferator activated receptor gamma (PPARgamma) expression in hepatocytes, thus sensitizing these cells to the well-known inhibitory effect of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15-d-PGJ(2)) on CTGF expression. 15-deoxy-delta 252-266 peroxisome proliferator activated receptor gamma Homo sapiens 96-144 19018984-3 2009 Recently, we demonstrated that the methylxanthine derivate caffeine leads to an upregulation of peroxisome proliferator activated receptor gamma (PPARgamma) expression in hepatocytes, thus sensitizing these cells to the well-known inhibitory effect of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15-d-PGJ(2)) on CTGF expression. 15-deoxy-delta 252-266 peroxisome proliferator activated receptor gamma Homo sapiens 146-155 19101554-1 2009 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) activates a nuclear receptor heterodimer, peroxisome proliferators-activated receptor gamma (PPARgamma)/ retinoid X receptor (RXRalpha) through covalent binding to Cys285 in PPARgamma ligand-binding domain (LBD). 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 147-156 19101554-1 2009 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) activates a nuclear receptor heterodimer, peroxisome proliferators-activated receptor gamma (PPARgamma)/ retinoid X receptor (RXRalpha) through covalent binding to Cys285 in PPARgamma ligand-binding domain (LBD). 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 228-237 18535203-6 2008 PMN chemotactic responses to formylmethionyl-leucyl-phenylalanine (fMLP) and IL-8 were dose-dependently inhibited by treatment with the PPAR-gamma ligands troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and by transfection of PMN-like HL-60 cells with a constitutively active PPAR-gamma construct. 15-deoxy-delta 172-186 peroxisome proliferator activated receptor gamma Homo sapiens 136-146 18983509-2 2009 Recently, we demonstrated that the natural peroxisome proliferator-activated receptor gamma (PPARgamma) ligand, 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), augments platelet numbers by increasing platelet release from megakaryocytes through the induction of reactive oxygen species (ROS). 15-deoxy-delta 112-126 peroxisome proliferator activated receptor gamma Homo sapiens 43-91 18983509-2 2009 Recently, we demonstrated that the natural peroxisome proliferator-activated receptor gamma (PPARgamma) ligand, 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), augments platelet numbers by increasing platelet release from megakaryocytes through the induction of reactive oxygen species (ROS). 15-deoxy-delta 112-126 peroxisome proliferator activated receptor gamma Homo sapiens 93-102 18535203-6 2008 PMN chemotactic responses to formylmethionyl-leucyl-phenylalanine (fMLP) and IL-8 were dose-dependently inhibited by treatment with the PPAR-gamma ligands troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and by transfection of PMN-like HL-60 cells with a constitutively active PPAR-gamma construct. 15-deoxy-delta 172-186 peroxisome proliferator activated receptor gamma Homo sapiens 299-309 16601291-6 2006 A PPARgamma activator, 15-deoxy-Delta(12,14)- prostaglandin J(2) (15d-PGJ(2)), significantly inhibited estrogen-responsive element-dependent transactivation by estradiol in MCF-7 cells, which was blocked by addition of a PPARgamma antagonist GW9662. 15-deoxy-delta 23-37 peroxisome proliferator activated receptor gamma Homo sapiens 2-11 17707368-0 2007 15-Deoxy-delta(12,14)-prostaglandin J(2) down-regulates CXCR4 on carcinoma cells through PPARgamma- and NFkappaB-mediated pathways. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 89-99 18615183-8 2008 In the present study, Abeta(1-42) synergistically elevated the expression of IL-12 and IL-23 triggered by inflammatory activation of microglia, and the peroxisome proliferator-activated receptor (PPAR)-gamma agonist 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) effectively blocked the elevation of these proinflammatory cytokines. 15-deoxy-delta 216-230 peroxisome proliferator activated receptor gamma Homo sapiens 152-207 16601291-6 2006 A PPARgamma activator, 15-deoxy-Delta(12,14)- prostaglandin J(2) (15d-PGJ(2)), significantly inhibited estrogen-responsive element-dependent transactivation by estradiol in MCF-7 cells, which was blocked by addition of a PPARgamma antagonist GW9662. 15-deoxy-delta 23-37 peroxisome proliferator activated receptor gamma Homo sapiens 221-230 16077033-1 2005 15-Deoxy-Delta(12,14) prostaglandin J2 (15d-PGJ2) is a natural ligand for the peroxisome proliferator-activated receptor gamma (PPARgamma) that exhibits antiproliferative activity in colon cancer cells, but its mechanism of action is still poorly understood. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 78-126 16484546-5 2006 Recently, we examined the role of PPARgamma in EAE and observed that administration of the PPARgamma agonist 15-deoxy-Delta(12,14) prostaglandin J2 exerted a significant therapeutic effect predominantly by inhibiting the activation and expansion of encephalitogenic T cells. 15-deoxy-delta 109-123 peroxisome proliferator activated receptor gamma Homo sapiens 34-43 16484546-5 2006 Recently, we examined the role of PPARgamma in EAE and observed that administration of the PPARgamma agonist 15-deoxy-Delta(12,14) prostaglandin J2 exerted a significant therapeutic effect predominantly by inhibiting the activation and expansion of encephalitogenic T cells. 15-deoxy-delta 109-123 peroxisome proliferator activated receptor gamma Homo sapiens 91-100 16386710-5 2006 In U937 cells niacin-induced expression of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), the most potent endogenous ligand of PPARgamma. 15-deoxy-delta 43-57 peroxisome proliferator activated receptor gamma Homo sapiens 135-144 16310861-6 2006 Additional to DP receptors, the PGD(2) metabolite 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) binds the nuclear peroxisome proliferator-activated receptor gamma (PPARgamma) and has the facility to initiate a variety of anti-inflammatory phenotypes either through or independent of PPARgamma association. 15-deoxy-delta 50-64 peroxisome proliferator activated receptor gamma Homo sapiens 110-158 16310861-6 2006 Additional to DP receptors, the PGD(2) metabolite 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) binds the nuclear peroxisome proliferator-activated receptor gamma (PPARgamma) and has the facility to initiate a variety of anti-inflammatory phenotypes either through or independent of PPARgamma association. 15-deoxy-delta 50-64 peroxisome proliferator activated receptor gamma Homo sapiens 160-169 16310861-6 2006 Additional to DP receptors, the PGD(2) metabolite 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) binds the nuclear peroxisome proliferator-activated receptor gamma (PPARgamma) and has the facility to initiate a variety of anti-inflammatory phenotypes either through or independent of PPARgamma association. 15-deoxy-delta 50-64 peroxisome proliferator activated receptor gamma Homo sapiens 279-288 16253239-5 2005 15-Deoxy-Delta(12,14) prostaglandin J2 is, an endogenous ligand for peroxisome proliferator-activated receptor gamma (PPARgamma), has been known to possess proapoptotic potential in diverse cell types. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 68-116 16253239-5 2005 15-Deoxy-Delta(12,14) prostaglandin J2 is, an endogenous ligand for peroxisome proliferator-activated receptor gamma (PPARgamma), has been known to possess proapoptotic potential in diverse cell types. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 118-127 16077033-1 2005 15-Deoxy-Delta(12,14) prostaglandin J2 (15d-PGJ2) is a natural ligand for the peroxisome proliferator-activated receptor gamma (PPARgamma) that exhibits antiproliferative activity in colon cancer cells, but its mechanism of action is still poorly understood. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 128-137 15531761-4 2005 We reported here that the PPARgamma agonists 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) and troglitazone, but not PPARalpha agonist WY-14643, inhibited TNFalpha-induced production of eotaxin and monocyte chemotactic protein-1 (MCP-1) but not IL-8. 15-deoxy-delta 45-59 peroxisome proliferator activated receptor gamma Homo sapiens 26-35 16020752-1 2005 OBJECTIVE: We recently reported that the peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) and ciglitazone increased cultured endothelial cell nitric oxide (NO) release without increasing the expression of endothelial nitric oxide synthase (eNOS). 15-deoxy-delta 110-124 peroxisome proliferator activated receptor gamma Homo sapiens 41-89 16020752-1 2005 OBJECTIVE: We recently reported that the peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) and ciglitazone increased cultured endothelial cell nitric oxide (NO) release without increasing the expression of endothelial nitric oxide synthase (eNOS). 15-deoxy-delta 110-124 peroxisome proliferator activated receptor gamma Homo sapiens 91-100 16000871-1 2005 15-deoxy-delta(12,14)-PGJ(2)(15d-PGJ(2)) is a natural ligand that activates the peroxisome proliferators-activated receptor (PPAR) gamma, a member of nuclear receptor family implicated in regulation of lipid metabolism and adipocyte differentiation. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 80-136 14607914-1 2003 15-Deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) is a naturally occurring cyclopentenone metabolite of PGD(2) that possesses both peroxisome proliferator-activated receptor gamma (PPAR-gamma)-dependent and PPAR-gamma-independent anti-inflammatory properties. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 123-171 15023995-4 2004 PPARgamma ligands 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)) and the thiazolidinedione troglitazone (TRO), but not PPARalpha ligand Wy14643, dose-dependently suppressed IL-1beta-induced PGE(2) production, as well as mPGES-1 protein and mRNA expression. 15-deoxy-delta 18-32 peroxisome proliferator activated receptor gamma Homo sapiens 0-9 14607914-1 2003 15-Deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) is a naturally occurring cyclopentenone metabolite of PGD(2) that possesses both peroxisome proliferator-activated receptor gamma (PPAR-gamma)-dependent and PPAR-gamma-independent anti-inflammatory properties. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 173-183 14607914-1 2003 15-Deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) is a naturally occurring cyclopentenone metabolite of PGD(2) that possesses both peroxisome proliferator-activated receptor gamma (PPAR-gamma)-dependent and PPAR-gamma-independent anti-inflammatory properties. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 199-209 14580366-4 2003 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a natural ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and affects the expression of various genes. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 78-126 14580366-4 2003 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a natural ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and affects the expression of various genes. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 128-138 14555212-3 2003 Recently, it has been shown that activation of PPARgamma by J(2) series cyclopentenone prostaglandins (cyPGs), especially 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) or synthetic agents, such as antidiabetic thiazolidinediones, causes anti-proliferation, apoptosis, differentiation, and anti-inflammation of certain types of cancer cells. 15-deoxy-delta 122-136 peroxisome proliferator activated receptor gamma Homo sapiens 47-56 12759491-2 2003 15-deoxy-delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and known to modulate the expression of various genes. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 70-118 12847270-3 2003 The results show that IFN-gamma-induced inducible NO synthase (iNOS) gene transcription, iNOS protein induction, and NO production are more sensitive to inhibition by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15dPGJ(2)) than by the other two PPARgamma agonists, GW1929 and ciglitazone. 15-deoxy-delta 167-181 peroxisome proliferator activated receptor gamma Homo sapiens 242-251 12759491-2 2003 15-deoxy-delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and known to modulate the expression of various genes. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 120-130 14515149-2 2003 The most potent endogenous PPARgamma activator is 15-deoxy-Delta(12,14)prostaglandin-J(2) (15d-PGJ(2)), whereas synthetic ligands include the oral antidiabetic drugs thiazolidinediones (TZDs). 15-deoxy-delta 50-64 peroxisome proliferator activated receptor gamma Homo sapiens 27-36 12604364-2 2003 Using real-time RT-PCR the present study investigates the impact of two PPAR-gamma agonists, 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and ciglitazone, on the expression of several proinflammatory genes in lipopolysaccharide (LPS)-stimulated human blood monocytes. 15-deoxy-delta 93-107 peroxisome proliferator activated receptor gamma Homo sapiens 72-82 12524224-3 2003 METHODS AND RESULTS: The PPARgamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) or ciglitazone, stimulated a PPAR response element-luciferase reporter construct in transfected porcine pulmonary artery endothelial cells (PAECs), demonstrating that PPARgamma was transcriptionally functional. 15-deoxy-delta 44-58 peroxisome proliferator activated receptor gamma Homo sapiens 25-34 12524224-3 2003 METHODS AND RESULTS: The PPARgamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) or ciglitazone, stimulated a PPAR response element-luciferase reporter construct in transfected porcine pulmonary artery endothelial cells (PAECs), demonstrating that PPARgamma was transcriptionally functional. 15-deoxy-delta 44-58 peroxisome proliferator activated receptor gamma Homo sapiens 261-270 11973610-2 2002 In the present study, we showed that human leukemic cell lines, not only myeloid but also lymphoid, express PPAR gamma and its activation by natural ligand (15-deoxy-Delta(12,14) - prostaglandin J(2)) and synthetic ligand (troglitazone) profoundly inhibited their proliferation by induction of apoptosis preferentially in the serum-free culture. 15-deoxy-delta 157-171 peroxisome proliferator activated receptor gamma Homo sapiens 108-118 12454768-3 2002 In this study, treatment with 15-deoxy-Delta(12,14)-PGJ(2) (15-PGJ(2)), a natural PPARgamma ligand, induced a significant reduction of oral squamous cell carcinoma cell growth, which was mainly attributed to upregulation of apoptosis. 15-deoxy-delta 30-44 peroxisome proliferator activated receptor gamma Homo sapiens 82-91 12065695-7 2002 Rheumatoid synovial cells expressed PPARgamma mRNA, and the PPARgamma ligands 15-deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone reduced the proliferation and induced apoptosis in synovial cells. 15-deoxy-delta 78-92 peroxisome proliferator activated receptor gamma Homo sapiens 60-69 11950812-6 2002 PPARgamma ligands, 15-deoxy-delta(12,)(14)-prostaglandin J2 (15d-PGJ2) and troglitazone (TGZ), suppressed DNA synthesis of HT-29 cells whereas ligands for PPARalpha and PPARdelta had no significant effects. 15-deoxy-delta 19-33 peroxisome proliferator activated receptor gamma Homo sapiens 0-9 12269390-3 2002 In the present report, we show that the expression of PPARgamma was significantly increased in tumor tissues from human colon cancer compared with non-tumor tissues and that PPARgamma ligands, 15-Deoxy-delta(12,14)prostaglandin J2 or ciglitizone, induced apoptosis in HT-29 cells, a human colon cancer cell line. 15-deoxy-delta 193-207 peroxisome proliferator activated receptor gamma Homo sapiens 54-63 12269390-3 2002 In the present report, we show that the expression of PPARgamma was significantly increased in tumor tissues from human colon cancer compared with non-tumor tissues and that PPARgamma ligands, 15-Deoxy-delta(12,14)prostaglandin J2 or ciglitizone, induced apoptosis in HT-29 cells, a human colon cancer cell line. 15-deoxy-delta 193-207 peroxisome proliferator activated receptor gamma Homo sapiens 174-183 11987982-7 2002 15-Deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)), a natural PPAR-gamma agonist, has a dose-dependent antiproliferative and cytotoxic effect on normal and malignant B cells as shown by [(3)H]thymidine and MTT assays. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 53-63 11872377-4 2002 Recently, synthetic antidiabetic thiazolidinediones (TZDs) and the natural prostaglandin D2 (PGD2) metabolite, 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2), have been identified as ligands for PPARgamma. 15-deoxy-delta 111-125 peroxisome proliferator activated receptor gamma Homo sapiens 198-207 11668172-2 2001 Several investigators have shown that the terminal derivative of prostaglandin J(2) (PGJ(2)) metabolism, 15-deoxy-Delta(12,14)-PGJ(2) (15dPGJ(2)), induces apoptosis in breast cancer cells and is a potent activator of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but 15dPGJ(2) effects can be mediated by PPARgamma-dependent and PPARgamma-independent mechanisms. 15-deoxy-delta 105-119 peroxisome proliferator activated receptor gamma Homo sapiens 296-305 11668172-2 2001 Several investigators have shown that the terminal derivative of prostaglandin J(2) (PGJ(2)) metabolism, 15-deoxy-Delta(12,14)-PGJ(2) (15dPGJ(2)), induces apoptosis in breast cancer cells and is a potent activator of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but 15dPGJ(2) effects can be mediated by PPARgamma-dependent and PPARgamma-independent mechanisms. 15-deoxy-delta 105-119 peroxisome proliferator activated receptor gamma Homo sapiens 349-358 11668172-2 2001 Several investigators have shown that the terminal derivative of prostaglandin J(2) (PGJ(2)) metabolism, 15-deoxy-Delta(12,14)-PGJ(2) (15dPGJ(2)), induces apoptosis in breast cancer cells and is a potent activator of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but 15dPGJ(2) effects can be mediated by PPARgamma-dependent and PPARgamma-independent mechanisms. 15-deoxy-delta 105-119 peroxisome proliferator activated receptor gamma Homo sapiens 349-358 11278956-5 2001 PPARgamma activators, troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), inhibited IL-1beta-induced PDGFalphaR expression and suppressed PDGF-induced proliferation activity of VSMCs. 15-deoxy-delta 39-53 peroxisome proliferator activated receptor gamma Homo sapiens 0-9 11390455-1 2001 Ligands for peroxisome proliferator-activated receptor gamma (PPARgamma), such as 15-deoxy-Delta(12,14)PGJ2 (15d-PGJ2) have been proposed as a new class of antiinflammatory compounds with possible clinical applications. 15-deoxy-delta 82-96 peroxisome proliferator activated receptor gamma Homo sapiens 12-60 11390455-1 2001 Ligands for peroxisome proliferator-activated receptor gamma (PPARgamma), such as 15-deoxy-Delta(12,14)PGJ2 (15d-PGJ2) have been proposed as a new class of antiinflammatory compounds with possible clinical applications. 15-deoxy-delta 82-96 peroxisome proliferator activated receptor gamma Homo sapiens 62-71 11401318-3 2001 All cell lines were found to express functionally active PPARgamma and a marked growth inhibition was induced by thiazolidinedione ligands troglitazone, and pioglitazone as well as with its natural ligand 15-deoxy-Delta(12,14)-prostaglandin J(2). 15-deoxy-delta 205-219 peroxisome proliferator activated receptor gamma Homo sapiens 57-66 11278336-2 2001 We investigated whether peroxisome proliferator-activated receptor gamma (PPARgamma) ligands (ciglitazone, troglitazone, and 15-deoxy-Delta(12,14) prostaglandin J(2)) inhibited cyclooxygenase-2 (COX-2) induction in human epithelial cells. 15-deoxy-delta 125-139 peroxisome proliferator activated receptor gamma Homo sapiens 24-72 11278336-2 2001 We investigated whether peroxisome proliferator-activated receptor gamma (PPARgamma) ligands (ciglitazone, troglitazone, and 15-deoxy-Delta(12,14) prostaglandin J(2)) inhibited cyclooxygenase-2 (COX-2) induction in human epithelial cells. 15-deoxy-delta 125-139 peroxisome proliferator activated receptor gamma Homo sapiens 74-83 11401521-5 2001 In contrast, both troglitazone (at 10 microM) and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2), at 15 microM), a natural ligand for PPARgamma, induce c-Jun phosphorylation by activation of c-Jun N-terminal kinase (JNK) through a posttranslational regulation of c-Jun activity, therefore increasing AP-1/DNA binding activity and transcriptional responses as results of increasing basal ICAM-1 gene expression. 15-deoxy-delta 50-64 peroxisome proliferator activated receptor gamma Homo sapiens 140-149 10671476-5 2000 Here we show that PPARgamma ligands, troglitazone and 15-deoxy-Delta(12,14) prostaglandin J(2), but not PPARalpha agonist Wy14643, inhibited IL-2 production and phytohemagglutinin-inducible proliferation in human peripheral blood T-cells in a dose-dependent manner. 15-deoxy-delta 54-68 peroxisome proliferator activated receptor gamma Homo sapiens 18-27 11159824-0 2001 Albumin regulates induction of peroxisome proliferator-activated receptor-gamma (PPARgamma) by 15-deoxy-delta(12-14)-prostaglandin J(2) in vitro and may be an important regulator of PPARgamma function in vivo. 15-deoxy-delta 95-109 peroxisome proliferator activated receptor gamma Homo sapiens 31-79 11159824-0 2001 Albumin regulates induction of peroxisome proliferator-activated receptor-gamma (PPARgamma) by 15-deoxy-delta(12-14)-prostaglandin J(2) in vitro and may be an important regulator of PPARgamma function in vivo. 15-deoxy-delta 95-109 peroxisome proliferator activated receptor gamma Homo sapiens 81-90 11159824-1 2001 We observed that serum contains a factor(s) that inhibits the induction of peroxisome proliferator-activated receptor-gamma (PPARgamma) by 15-deoxy-Delta(12,14)-PGJ(2) (15dJ(2)). 15-deoxy-delta 139-153 peroxisome proliferator activated receptor gamma Homo sapiens 75-123 11159824-1 2001 We observed that serum contains a factor(s) that inhibits the induction of peroxisome proliferator-activated receptor-gamma (PPARgamma) by 15-deoxy-Delta(12,14)-PGJ(2) (15dJ(2)). 15-deoxy-delta 139-153 peroxisome proliferator activated receptor gamma Homo sapiens 125-134 10827178-2 2000 The PGD(2) metabolite 15-deoxy-Delta(12, 14) PGJ(2) (15d-PGJ(2)) was identified as a potent natural ligand for the peroxisome proliferator-activated receptor-gamma (PPARgamma). 15-deoxy-delta 22-36 peroxisome proliferator activated receptor gamma Homo sapiens 115-163 10827178-2 2000 The PGD(2) metabolite 15-deoxy-Delta(12, 14) PGJ(2) (15d-PGJ(2)) was identified as a potent natural ligand for the peroxisome proliferator-activated receptor-gamma (PPARgamma). 15-deoxy-delta 22-36 peroxisome proliferator activated receptor gamma Homo sapiens 165-174 10936413-0 2000 15-deoxy-Delta(12,14)PGJ(2) induces diverse biological responses via PPARgamma activation in cancer cells. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 69-78 10807869-1 2000 Ligands for peroxisome proliferator-activated receptor gamma, such as the thiazolidinedione class of antidiabetic drugs and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), modulate various processes in atherogenesis. 15-deoxy-delta 124-138 peroxisome proliferator activated receptor gamma Homo sapiens 12-60 11030710-4 2000 ECV-ACO.Luc respond to the PPARgamma agonists, 15-deoxy-Delta(12,14) PGJ(2), and ciglitizone, by inducing luciferase expression. 15-deoxy-delta 47-61 peroxisome proliferator activated receptor gamma Homo sapiens 27-36 32215785-5 2020 MCs support angiogenesis in AT by releasing chymase and inducing preadipocyte differentiation and also the proliferation of adipocytes through 15-deoxy-delta PGJ2/PPARgamma interaction. 15-deoxy-delta 143-157 peroxisome proliferator activated receptor gamma Homo sapiens 163-172