PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30611741-5 2019 We here assessed the therapeutic efficacy of the orally bioavailable BRD4 inhibitor, MK-8628, in preclinical models of medulloblastoma. OTX015 85-92 bromodomain containing 4 Homo sapiens 69-73 26976114-0 2016 Clinical Response of Carcinomas Harboring the BRD4-NUT Oncoprotein to the Targeted Bromodomain Inhibitor OTX015/MK-8628. OTX015 112-119 bromodomain containing 4 Homo sapiens 46-50 27063978-1 2016 BACKGROUND: The first-in-class small molecule inhibitor OTX015 (MK-8628) specifically binds to bromodomain motifs BRD2, BRD3, and BRD4 of bromodomain and extraterminal (BET) proteins, inhibiting them from binding to acetylated histones, which occurs preferentially at super-enhancer regions that control oncogene expression. OTX015 64-71 bromodomain containing 4 Homo sapiens 130-134