PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21645192-7	2011	Annexin A2 is a Ca(2+) and phosphatidylinositol 4,5-bisphosphate binding protein, previously implicated in several endocytic steps.	Phosphatidylinositol 4,5-Diphosphate	27-64	annexin A2	Homo sapiens	0-10	
19325895-0	2009	Anx2 interacts with HIV-1 Gag at phosphatidylinositol (4,5) bisphosphate-containing lipid rafts and increases viral production in 293T cells.	Phosphatidylinositol 4,5-Diphosphate	33-72	annexin A2	Homo sapiens	0-4	
20374557-8	2010	In addition, these results showed that the formation of phosphatidylinositol (4,5)-bisphosphate (PIP(2)) microdomains colocalized with S100A10 in the vicinity of docked granules, suggesting a functional interplay between annexin-A2-mediated lipid microdomains and SNAREs during exocytosis.	Phosphatidylinositol 4,5-Diphosphate	56-95	annexin A2	Homo sapiens	221-231	
20374557-8	2010	In addition, these results showed that the formation of phosphatidylinositol (4,5)-bisphosphate (PIP(2)) microdomains colocalized with S100A10 in the vicinity of docked granules, suggesting a functional interplay between annexin-A2-mediated lipid microdomains and SNAREs during exocytosis.	Phosphatidylinositol 4,5-Diphosphate	97-103	annexin A2	Homo sapiens	221-231	
17712229-7	2007	Apically localized phosphatidylinositol(4,5)-bisphosphate [PtdIns(4,5)P2] recruits the scaffolding protein Annexin2 and the GTPase Cdc42 to generate the apical plasma membrane domain and the central lumen.	Phosphatidylinositol 4,5-Diphosphate	19-57	annexin A2	Homo sapiens	107-115	
17712229-7	2007	Apically localized phosphatidylinositol(4,5)-bisphosphate [PtdIns(4,5)P2] recruits the scaffolding protein Annexin2 and the GTPase Cdc42 to generate the apical plasma membrane domain and the central lumen.	Phosphatidylinositol 4,5-Diphosphate	59-72	annexin A2	Homo sapiens	107-115	
17254974-4	2007	Annexin 2 (Anx2) binds PtdIns(4,5)P2 and is recruited to the apical surface.	Phosphatidylinositol 4,5-Diphosphate	23-36	annexin A2	Homo sapiens	0-9	
17254974-4	2007	Annexin 2 (Anx2) binds PtdIns(4,5)P2 and is recruited to the apical surface.	Phosphatidylinositol 4,5-Diphosphate	23-36	annexin A2	Homo sapiens	11-15	
16230353-2	2005	It has been reported that annexin A2 is involved in binding to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and in inducing membrane microdomain formation.	Phosphatidylinositol 4,5-Diphosphate	63-100	annexin A2	Homo sapiens	26-36	
16230353-2	2005	It has been reported that annexin A2 is involved in binding to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and in inducing membrane microdomain formation.	Phosphatidylinositol 4,5-Diphosphate	102-115	annexin A2	Homo sapiens	26-36	
16230353-4	2005	Our results from surface plasmon resonance analysis showed that A2t and annexin A2 has modest selectivity for PtdIns(4,5)P2 over other phosphoinositides, which is conferred by conserved basic residues, including Lys279 and Lys281, on the convex surface of annexin A2.	Phosphatidylinositol 4,5-Diphosphate	110-123	annexin A2	Homo sapiens	72-82	
16230353-4	2005	Our results from surface plasmon resonance analysis showed that A2t and annexin A2 has modest selectivity for PtdIns(4,5)P2 over other phosphoinositides, which is conferred by conserved basic residues, including Lys279 and Lys281, on the convex surface of annexin A2.	Phosphatidylinositol 4,5-Diphosphate	110-123	annexin A2	Homo sapiens	256-266	
25418092-0	2014	Cooperative binding of annexin A2 to cholesterol- and phosphatidylinositol-4,5-bisphosphate-containing bilayers.	Phosphatidylinositol 4,5-Diphosphate	54-91	annexin A2	Homo sapiens	23-33	
25418092-4	2014	Here, we performed a quantitative analysis of the binding of AnxA2 to solid supported membranes containing the annexin binding lipids phosphatidylinositol-4,5-bisphosphate and phosphatidylserine in different compositions.	Phosphatidylinositol 4,5-Diphosphate	134-171	annexin A2	Homo sapiens	61-66	
25418092-9	2014	Together our results reveal for the first time, to our knowledge, that AnxA2 and its derivatives bind cooperatively to membranes containing cholesterol, phosphatidylserine, and/or phosphatidylinositol-4,5-bisphosphate, thus providing a mechanistic model for the lipid clustering activity of AnxA2.	Phosphatidylinositol 4,5-Diphosphate	180-217	annexin A2	Homo sapiens	71-76	
23631697-9	2014	In contrast, PtdIns(4,5)P2 colocalized with the lipid raft markers flotillin-1 and annexin 2, within GVD bodies and NFTs.	Phosphatidylinositol 4,5-Diphosphate	13-26	annexin A2	Homo sapiens	83-92	
23861394-3	2013	Here we analyzed the ability of one peripherally associated membrane protein, annexin A2 (AnxA2), to induce the formation of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-rich domains in giant unilamellar vesicles (GUVs) of complex lipid composition.	Phosphatidylinositol 4,5-Diphosphate	125-162	annexin A2	Homo sapiens	78-88	
23861394-3	2013	Here we analyzed the ability of one peripherally associated membrane protein, annexin A2 (AnxA2), to induce the formation of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2)-rich domains in giant unilamellar vesicles (GUVs) of complex lipid composition.	Phosphatidylinositol 4,5-Diphosphate	125-162	annexin A2	Homo sapiens	90-95