PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9726240-7	1998	Pretreatment with troglitazone and vitamin E, but not with pioglitazone, resulted in decreases in thrombin-induced phosphatidic acid production, hydrolysis of phosphatidylinositol 4,5-bisphosphate by phospholipase C, and 47-kDa protein phosphorylation.	Phosphatidylinositol 4,5-Diphosphate	159-196	coagulation factor II, thrombin	Homo sapiens	98-106	
18503745-1	2008	Incubation of platelets with increasing concentrations of thrombin produced large amounts of phosphatidic acid (PA) and distinct changes in phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2), prominent metabolites in the polyphosphoinositide (PPI) cycle.	Phosphatidylinositol 4,5-Diphosphate	183-220	coagulation factor II, thrombin	Homo sapiens	58-66	
18503745-1	2008	Incubation of platelets with increasing concentrations of thrombin produced large amounts of phosphatidic acid (PA) and distinct changes in phosphatidylinositol-4-phosphate (PIP) and phosphatidylinositol-4,5-bisphosphate (PIP2), prominent metabolites in the polyphosphoinositide (PPI) cycle.	Phosphatidylinositol 4,5-Diphosphate	222-226	coagulation factor II, thrombin	Homo sapiens	58-66	
18503745-2	2008	The relation between normalized PA and PIP or PIP2 levels in such thrombin-treated platelets from 22 normal donors gave a very similar pattern, suggesting tight control of the metabolites in the polyphosphoinositide (PPI) cycle.	Phosphatidylinositol 4,5-Diphosphate	46-50	coagulation factor II, thrombin	Homo sapiens	66-74	
17719101-2	2008	We report that inclusion of a PIP2 analogue, PIP2 1,2-dioctanoyl, does not induce non-capacitative Ca2+ entry per se but enhanced Ca2+ entry stimulated either by thrombin or by selective depletion of the Ca2+ stores in platelets, the dense tubular system, using 10 nM TG, and the acidic stores, using 20 microM 2,5-di-(tert-butyl)-1,4-hydroquinone (TBHQ).	Phosphatidylinositol 4,5-Diphosphate	30-34	coagulation factor II, thrombin	Homo sapiens	162-170	
17719101-3	2008	Reduction of PIP2 levels by blocking PIP2 resynthesis with Li+ or introducing a monoclonal anti-PIP2 antibody, or sequestering PIP2 using poly-lysine, attenuated Ca2+ entry induced by thrombin, TG and TBHQ, and reduced thrombin-evoked, but not TG- or TBHQ-induced, Ca2+ release from the stores.	Phosphatidylinositol 4,5-Diphosphate	13-17	coagulation factor II, thrombin	Homo sapiens	184-192	
17719101-3	2008	Reduction of PIP2 levels by blocking PIP2 resynthesis with Li+ or introducing a monoclonal anti-PIP2 antibody, or sequestering PIP2 using poly-lysine, attenuated Ca2+ entry induced by thrombin, TG and TBHQ, and reduced thrombin-evoked, but not TG- or TBHQ-induced, Ca2+ release from the stores.	Phosphatidylinositol 4,5-Diphosphate	13-17	coagulation factor II, thrombin	Homo sapiens	219-227	
15447683-8	2004	Thrombin and LPA receptors also differentially activated Gq pathways as thrombin but not LPA increased InsP3 formation and reduced phosphatidylinositol 4,5-bisphosphate (PIP2) levels.	Phosphatidylinositol 4,5-Diphosphate	131-168	coagulation factor II, thrombin	Homo sapiens	0-8	
15447683-8	2004	Thrombin and LPA receptors also differentially activated Gq pathways as thrombin but not LPA increased InsP3 formation and reduced phosphatidylinositol 4,5-bisphosphate (PIP2) levels.	Phosphatidylinositol 4,5-Diphosphate	131-168	coagulation factor II, thrombin	Homo sapiens	72-80	
15447683-8	2004	Thrombin and LPA receptors also differentially activated Gq pathways as thrombin but not LPA increased InsP3 formation and reduced phosphatidylinositol 4,5-bisphosphate (PIP2) levels.	Phosphatidylinositol 4,5-Diphosphate	170-174	coagulation factor II, thrombin	Homo sapiens	0-8	
15447683-8	2004	Thrombin and LPA receptors also differentially activated Gq pathways as thrombin but not LPA increased InsP3 formation and reduced phosphatidylinositol 4,5-bisphosphate (PIP2) levels.	Phosphatidylinositol 4,5-Diphosphate	170-174	coagulation factor II, thrombin	Homo sapiens	72-80	
9633924-8	1998	Taken together, these findings indicate that the HDL3-mediated inhibition of thrombin-induced fibrinogen binding and aggregation occurs via inhibition of phosphatidylinositol 4,5-bis-phosphate turnover and formation of 1,2-diacylglycerol and inositol 1,4,5-tris-phosphate.	Phosphatidylinositol 4,5-Diphosphate	154-192	coagulation factor II, thrombin	Homo sapiens	77-85	
9405283-1	1998	PtdIns(4,5)P2 production by the enzyme PtdIns4P 5-kinase C (PIPkin C) was examined in thrombin-stimulated human platelets.	Phosphatidylinositol 4,5-Diphosphate	0-13	coagulation factor II, thrombin	Homo sapiens	86-94	
7492569-9	1995	Transduction of growth signals by G protein-coupled receptors such as those for thrombin or bombesin also requires PtdIns(4,5)P2 hydrolysis, which, in this instance, is mediated by PLC-beta isozymes.	Phosphatidylinositol 4,5-Diphosphate	115-128	coagulation factor II, thrombin	Homo sapiens	80-88	
8573071-5	1996	Time-course studies (0-180 s) comparing equivalent concentrations of cathepsin G (3 microM) and thrombin (0.5 unit/ml) resulted in very similar transient hydrolysis of phosphatidylinositol 4,5-bisphosphate and steady accumulation of phosphatidic acid.	Phosphatidylinositol 4,5-Diphosphate	168-205	coagulation factor II, thrombin	Homo sapiens	96-104	
2044838-10	1991	The data indicate that all DAG is converted to PA and support our conclusion that phosphatidylinositol 4,5-bisphosphate represents the major source for production of DAG upon stimulation of human platelets with low concentrations of thrombin.	Phosphatidylinositol 4,5-Diphosphate	82-119	coagulation factor II, thrombin	Homo sapiens	233-241	
8042983-0	1994	Phosphatidylinositol 3,4,5-trisphosphate is formed from phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.	Phosphatidylinositol 4,5-Diphosphate	56-93	coagulation factor II, thrombin	Homo sapiens	97-105	
8400019-2	1993	Muscarinic, alpha 1-adrenergic, angiotensin II, endothelin-1, thrombin, adenine nucleotide and opioid peptide receptors are all linked through GTP-binding proteins to phospholipase C which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) in the myocardium.	Phosphatidylinositol 4,5-Diphosphate	200-237	coagulation factor II, thrombin	Homo sapiens	62-70	
8400019-2	1993	Muscarinic, alpha 1-adrenergic, angiotensin II, endothelin-1, thrombin, adenine nucleotide and opioid peptide receptors are all linked through GTP-binding proteins to phospholipase C which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) in the myocardium.	Phosphatidylinositol 4,5-Diphosphate	239-243	coagulation factor II, thrombin	Homo sapiens	62-70	
8396627-6	1993	Thrombin-stimulated decreases in PIP2 and PIP, found in the presence of U73122, could be explained by the action of phospholipase C in the absence of resynthesis.	Phosphatidylinositol 4,5-Diphosphate	33-37	coagulation factor II, thrombin	Homo sapiens	0-8	
8391903-2	1993	Studies were designed to explore the effects of thrombin, LDL, HDL plus LDL on the changes of the important metabolites: phosphatidylinositol-4,5-bisphosphate (PIP2) and phosphatidic acid (PA) of phosphatidylinositol cycle (PI).	Phosphatidylinositol 4,5-Diphosphate	121-158	coagulation factor II, thrombin	Homo sapiens	48-56	
8391903-2	1993	Studies were designed to explore the effects of thrombin, LDL, HDL plus LDL on the changes of the important metabolites: phosphatidylinositol-4,5-bisphosphate (PIP2) and phosphatidic acid (PA) of phosphatidylinositol cycle (PI).	Phosphatidylinositol 4,5-Diphosphate	160-164	coagulation factor II, thrombin	Homo sapiens	48-56	
8391903-3	1993	The results indicated that both thrombin and LDL caused a significant decrease of PIP2 within 15 seconds.	Phosphatidylinositol 4,5-Diphosphate	82-86	coagulation factor II, thrombin	Homo sapiens	32-40	
8391903-6	1993	The effects of thrombin or LDL on PIP2 decrease and PA increase were also both dose-dependent.	Phosphatidylinositol 4,5-Diphosphate	34-38	coagulation factor II, thrombin	Homo sapiens	15-23	
1314112-14	1992	In this model of PLD activation, alpha-thrombin receptor occupancy leads to the breakdown of phosphatidylinositol 4,5-bisphosphate catalyzed by phospholipase C producing the Ca2+ secretagogue IP3 and DAG.	Phosphatidylinositol 4,5-Diphosphate	93-130	coagulation factor II, thrombin	Homo sapiens	39-47	
1309423-4	1992	EC significantly blocked the thrombin stimulated breakdown of phosphatidylinositol-4,5-bisphosphate (PIP2) and the production of phosphatidic acid in [32P]orthophosphate-labeled platelets and of inositol trisphosphate in [3H]myoinositol-labeled platelets.	Phosphatidylinositol 4,5-Diphosphate	62-99	coagulation factor II, thrombin	Homo sapiens	29-37	
1309423-4	1992	EC significantly blocked the thrombin stimulated breakdown of phosphatidylinositol-4,5-bisphosphate (PIP2) and the production of phosphatidic acid in [32P]orthophosphate-labeled platelets and of inositol trisphosphate in [3H]myoinositol-labeled platelets.	Phosphatidylinositol 4,5-Diphosphate	101-105	coagulation factor II, thrombin	Homo sapiens	29-37	
1309423-7	1992	These data indicate that EDRF blocks thrombin-induced platelet aggregation by inhibiting the activation of PIP2-specific phospholipase C and thereby suppressing the consequent activation of PKC and the mobilization of [Ca2+]i.	Phosphatidylinositol 4,5-Diphosphate	107-111	coagulation factor II, thrombin	Homo sapiens	37-45	
1647205-5	1991	EIA and nigericin also caused a marked increase in thrombin-induced breakdown and inhibition of resynthesis of phosphatidylinositol 4,5-bisphosphate (PIP2).	Phosphatidylinositol 4,5-Diphosphate	111-148	coagulation factor II, thrombin	Homo sapiens	51-59	
1647205-5	1991	EIA and nigericin also caused a marked increase in thrombin-induced breakdown and inhibition of resynthesis of phosphatidylinositol 4,5-bisphosphate (PIP2).	Phosphatidylinositol 4,5-Diphosphate	150-154	coagulation factor II, thrombin	Homo sapiens	51-59	
7926350-9	1994	These results suggest that sulphonylureas and insulin induce suppression of thrombin-induced activation of phospholipase C, which mediates hydrolysis of PIP and PIP2 and production of PA, which leads to inhibition of platelet aggregation.	Phosphatidylinositol 4,5-Diphosphate	161-165	coagulation factor II, thrombin	Homo sapiens	76-84	
1655398-5	1991	The addition of thrombin induced a marked decrease in PIP2 radioactivity at 10 sec in platelets from group I compared with that from the control.	Phosphatidylinositol 4,5-Diphosphate	54-58	coagulation factor II, thrombin	Homo sapiens	16-24	
2159285-2	1990	Thrombin caused a transient fall in PtdInsP and PtdInsP2 levels, accompanied by a rise in diacylglycerol and phosphatidic acid, indicative of a classical phospholipase C/diacylglycerol kinase pathway.	Phosphatidylinositol 4,5-Diphosphate	36-43	coagulation factor II, thrombin	Homo sapiens	0-8	
1987304-4	1991	Soluble mediators such as thrombin or histamine cause endothelial cell activation via a signal transduction mechanism that hydrolyzes phosphatidylinositol 4,5-bisphosphate (IP), liberating inositol trisphosphate (IP3).	Phosphatidylinositol 4,5-Diphosphate	134-171	coagulation factor II, thrombin	Homo sapiens	26-34	
2174010-5	1990	Hydrolysis of PIP2, PIP, and PI; accumulation of PA; and phosphorylation of P20 in platelets stimulated by 0.05 U/ml thrombin were significantly increased in the DM-A group compared with the control or DM-B group.	Phosphatidylinositol 4,5-Diphosphate	14-18	coagulation factor II, thrombin	Homo sapiens	117-125	
2159285-2	1990	Thrombin caused a transient fall in PtdInsP and PtdInsP2 levels, accompanied by a rise in diacylglycerol and phosphatidic acid, indicative of a classical phospholipase C/diacylglycerol kinase pathway.	Phosphatidylinositol 4,5-Diphosphate	48-56	coagulation factor II, thrombin	Homo sapiens	0-8	
2539864-0	1989	Plasma membrane associated phospholipase C from human platelets: synergistic stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by thrombin and guanosine 5"-O-(3-thiotriphosphate).	Phosphatidylinositol 4,5-Diphosphate	92-129	coagulation factor II, thrombin	Homo sapiens	144-152	
2154447-4	1990	We demonstrate the formation of PtdIns(3,4)P2 in human platelets and show that the synthesis of this lipid (and of PtdIns(4,5)P2) is stimulated during activation of platelets by thrombin.	Phosphatidylinositol 4,5-Diphosphate	115-128	coagulation factor II, thrombin	Homo sapiens	178-186	
9795233-4	1998	The thrombin-induced (0.1 U/ml) increase in production of [32P]PA, "overshoots" in [32P]PIP and [32P]PIP2 ([32P]phosphatidylinositol 4,5-bisphosphate), and the increase in [32P]PI and secretion of ADP+ATP were abolished by forskolin (10-7 M).	Phosphatidylinositol 4,5-Diphosphate	101-105	coagulation factor II, thrombin	Homo sapiens	4-12	
9795233-4	1998	The thrombin-induced (0.1 U/ml) increase in production of [32P]PA, "overshoots" in [32P]PIP and [32P]PIP2 ([32P]phosphatidylinositol 4,5-bisphosphate), and the increase in [32P]PI and secretion of ADP+ATP were abolished by forskolin (10-7 M).	Phosphatidylinositol 4,5-Diphosphate	112-149	coagulation factor II, thrombin	Homo sapiens	4-12	
2548908-10	1989	There was significantly decreased [32P]PIP2 and [32P]PIP hydrolysis and decreased [32P]PA formation in IDDM after platelet stimulation with 4 U/ml human thrombin.	Phosphatidylinositol 4,5-Diphosphate	39-43	coagulation factor II, thrombin	Homo sapiens	153-161	
2537741-2	1989	Cyclic nucleotide-elevating vasodilators stimulated cAMP- or cGMP-dependent protein phosphorylation, inhibited the activation of both protein kinase C and myosin light chain kinase, and inhibited the thrombin-induced hydrolysis of phosphatidylinositol-4,5-bisphosphate without affecting its resynthesis.	Phosphatidylinositol 4,5-Diphosphate	231-268	coagulation factor II, thrombin	Homo sapiens	200-208	
2539864-6	1989	At submicromolar calcium concentration, hydrolysis of exogenous phosphatidylinositol 4,5-bisphosphate (PIP2) by platelet membrane associated PLC was also markedly enhanced by GTP gamma S (100 microM) or GTP gamma S (1 microM) plus thrombin (1 unit/mL).	Phosphatidylinositol 4,5-Diphosphate	64-101	coagulation factor II, thrombin	Homo sapiens	231-239	
2539864-6	1989	At submicromolar calcium concentration, hydrolysis of exogenous phosphatidylinositol 4,5-bisphosphate (PIP2) by platelet membrane associated PLC was also markedly enhanced by GTP gamma S (100 microM) or GTP gamma S (1 microM) plus thrombin (1 unit/mL).	Phosphatidylinositol 4,5-Diphosphate	103-107	coagulation factor II, thrombin	Homo sapiens	231-239	
2539864-9	1989	Thrombin-induced hydrolysis of PIP2 was inhibited by treatment of the membranes with pertussis toxin or pretreatment of intact platelets with 12-O-tetradecanoyl-13-acetate (TPA) prior to preparation of membranes.	Phosphatidylinositol 4,5-Diphosphate	31-35	coagulation factor II, thrombin	Homo sapiens	0-8	
2822018-1	1987	One of the earliest actions of thrombin in fibroblasts is stimulation of a phospholipase C (PLC) that hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol.	Phosphatidylinositol 4,5-Diphosphate	113-150	coagulation factor II, thrombin	Homo sapiens	31-39	
2845924-5	1988	The thrombin-induced hydrolysis of inositol phospholipids by phospholipase C, which was measured as the formation of [32P]PA, was potentiated by adrenaline, as was the increase in the levels of [32P]PIP2 and [32P]PIP.	Phosphatidylinositol 4,5-Diphosphate	199-203	coagulation factor II, thrombin	Homo sapiens	4-12	
2822029-0	1987	Phosphatidylinositol 4,5-bisphosphate is selectively retained by platelet-fibrin clots formed by thrombin.	Phosphatidylinositol 4,5-Diphosphate	0-37	coagulation factor II, thrombin	Homo sapiens	97-105	
2822029-6	1987	Thus, when platelets are stimulated with thrombin in the presence of fibrinogen, an association of polymerizing fibrin with the stimulated platelets occurs that leads to decreased extractability of PIP2.	Phosphatidylinositol 4,5-Diphosphate	198-202	coagulation factor II, thrombin	Homo sapiens	41-49	
2822018-1	1987	One of the earliest actions of thrombin in fibroblasts is stimulation of a phospholipase C (PLC) that hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol.	Phosphatidylinositol 4,5-Diphosphate	152-156	coagulation factor II, thrombin	Homo sapiens	31-39	
2822018-2	1987	In membranes prepared from WI-38 human lung fibroblasts, thrombin activated an inositol-lipid-specific PLC that hydrolysed [32P]PIP2 and [32P]phosphatidylinositol 4-monophosphate (PIP) to [32P]IP3 and [32P]inositol 1,4-bisphosphate (IP2) respectively.	Phosphatidylinositol 4,5-Diphosphate	128-132	coagulation factor II, thrombin	Homo sapiens	57-65	
2822018-11	1987	It is concluded that an early post-receptor effect of thrombin is the activation of a Ca2+- and GTP-dependent membrane-associated PLC that specifically cleaves PIP2 and PIP.	Phosphatidylinositol 4,5-Diphosphate	160-164	coagulation factor II, thrombin	Homo sapiens	54-62	
3115311-2	1987	These early changes in shape are accompanied by a transient decrease (30%) in phosphatidyl inositol 4,5-bisphosphate (PIP2) which occurs in the first 10 s after thrombin addition.	Phosphatidylinositol 4,5-Diphosphate	78-116	coagulation factor II, thrombin	Homo sapiens	161-169	
3036588-6	1987	Prolonged incubation of the unstimulated cells as well as stimulation with thrombin induced a similar 5-6 fold increase in specific radioactivity of the diester phosphate of PI, PIP and PIP2.	Phosphatidylinositol 4,5-Diphosphate	186-190	coagulation factor II, thrombin	Homo sapiens	75-83	
3032933-0	1987	Thrombin- and nucleotide-activated phosphatidylinositol 4,5-bisphosphate phospholipase C in human platelet membranes.	Phosphatidylinositol 4,5-Diphosphate	35-72	coagulation factor II, thrombin	Homo sapiens	0-8	
3032933-1	1987	Thrombin, nucleotides, and chelators elicited a phosphatidylinositol 4,5-bisphosphate (PtdIns-P2) phospholipase C activity that was associated with human platelet membranes.	Phosphatidylinositol 4,5-Diphosphate	48-85	coagulation factor II, thrombin	Homo sapiens	0-8	
3032933-1	1987	Thrombin, nucleotides, and chelators elicited a phosphatidylinositol 4,5-bisphosphate (PtdIns-P2) phospholipase C activity that was associated with human platelet membranes.	Phosphatidylinositol 4,5-Diphosphate	87-96	coagulation factor II, thrombin	Homo sapiens	0-8	
3032933-5	1987	Only PtdIns-P2 was degraded by the phospholipase C activated by alpha-thrombin, nucleotides, and chelators.	Phosphatidylinositol 4,5-Diphosphate	5-14	coagulation factor II, thrombin	Homo sapiens	70-78	
3032933-7	1987	The pH optimum for the membrane-associated phospholipase C in the presence of alpha-thrombin or nucleotides was 6.0, and the PtdIns-P2 phospholipase C was inhibited by neomycin and high detergent concentrations.	Phosphatidylinositol 4,5-Diphosphate	125-134	coagulation factor II, thrombin	Homo sapiens	84-92	
3115311-2	1987	These early changes in shape are accompanied by a transient decrease (30%) in phosphatidyl inositol 4,5-bisphosphate (PIP2) which occurs in the first 10 s after thrombin addition.	Phosphatidylinositol 4,5-Diphosphate	118-122	coagulation factor II, thrombin	Homo sapiens	161-169	
3026339-3	1986	At non-lytic concentrations, chlorpromazine caused a dramatic increase in the thrombin- or phorbol ester-mediated incorporation of 32P into phosphatidylinositol 4-phosphate and, to a lesser extent, into phosphatidylinositol 4,5-bisphosphate in platelets pulse-labelled with [32P]Pi.	Phosphatidylinositol 4,5-Diphosphate	203-240	coagulation factor II, thrombin	Homo sapiens	78-86	
3026850-5	1987	The thrombin-induced cleavage of phosphatidylinositol 4,5-bisphosphate (PIP2) was unaffected by treatments that blocked Na+/H+ exchange or increased pHi.	Phosphatidylinositol 4,5-Diphosphate	33-70	coagulation factor II, thrombin	Homo sapiens	4-12	
3026850-5	1987	The thrombin-induced cleavage of phosphatidylinositol 4,5-bisphosphate (PIP2) was unaffected by treatments that blocked Na+/H+ exchange or increased pHi.	Phosphatidylinositol 4,5-Diphosphate	72-76	coagulation factor II, thrombin	Homo sapiens	4-12	
2830631-6	1987	When added to CPZ--pretreated 32P prelabelled platelets, thrombin decreased the radio-activity in PIP2, PIP, and PA to 4, 86, and 10% of the control, respectively.	Phosphatidylinositol 4,5-Diphosphate	98-102	coagulation factor II, thrombin	Homo sapiens	57-65	
3023367-2	1986	In platelets activated by thrombin, the hydrolysis of phosphatidylinositol 4,5-bisphosphate by phospholipase C produces inositol 1,4,5-triphosphate (IP3) and diacylglycerol, metabolites which are known to cause Ca2+ release from the platelet dense tubular system and granule secretion.	Phosphatidylinositol 4,5-Diphosphate	54-91	coagulation factor II, thrombin	Homo sapiens	26-34	
3018731-2	1986	We have now isolated the cyclic product of phosphatidylinositol 4,5-bisphosphate cleavage, inositol 1,2(cyclic)-4,5-triphosphate [cIns(1:2,4,5)P3], from thrombin-treated platelets.	Phosphatidylinositol 4,5-Diphosphate	43-80	coagulation factor II, thrombin	Homo sapiens	153-161	
3755042-2	1986	With thrombin, which is known to cause substantial, rapid hydrolysis of phosphatidylinositol-4,5-bisphosphate, the mean delay before a detectible rise in [Ca2+]i in medium containing 1 mM Ca2+ o was 250 +/- 10 msec (S.E.M., n = 11).	Phosphatidylinositol 4,5-Diphosphate	72-109	coagulation factor II, thrombin	Homo sapiens	5-13	
3011769-1	1986	The early breakdown of phosphatidylinositol 4,5-bisphosphate in human platelets stimulated by a threshold concentration of either collagen or thrombin was inhibited by 5 mM NaF through its inhibition of phospholipase C activity.	Phosphatidylinositol 4,5-Diphosphate	23-60	coagulation factor II, thrombin	Homo sapiens	142-150	
2990473-1	1985	Phosphatidylinositol-4,5-bisphosphate decreased 40% within 10 seconds after the addition of thrombin to platelets.	Phosphatidylinositol 4,5-Diphosphate	0-37	coagulation factor II, thrombin	Homo sapiens	92-100	
2999166-2	1985	Thrombin and EGF stimulated comparable increases in the synthesis (30-50%) and degradation (20-40%) of phosphatidylinositol 4-monophosphate (DPI) and phosphatidylinositol 4,5-bisphosphate (TPI) in a cell line which is mitogenically responsive to both growth factors.	Phosphatidylinositol 4,5-Diphosphate	150-187	coagulation factor II, thrombin	Homo sapiens	0-8	
3874867-6	1985	Incubation of platelets with a stimulus for protein kinase C, 12-O-tetradecanoyl phorbol 13-acetate, prior to the addition of thrombin impairs the hydrolysis of PIP2 and the increase in IP3, with 50% inhibition occurring at 60 nM TPA.	Phosphatidylinositol 4,5-Diphosphate	161-165	coagulation factor II, thrombin	Homo sapiens	126-134	
2987951-0	1985	Phorbol myristate acetate inhibits thrombin-stimulated Ca2+ mobilization and phosphatidylinositol 4,5-bisphosphate hydrolysis in human platelets.	Phosphatidylinositol 4,5-Diphosphate	77-114	coagulation factor II, thrombin	Homo sapiens	35-43	
6525180-7	1984	A transient decrease in the mass of PtdIns(4,5)P2 was observed after 5-10s of thrombin stimulation, followed by an increase after 30s.	Phosphatidylinositol 4,5-Diphosphate	36-49	coagulation factor II, thrombin	Homo sapiens	78-86	
2997707-4	1985	When platelets are stimulated by thrombin, a rapid phosphatidylinositol bisphosphate (PIP2) breakdown is observed, accompanied by an immediate PA synthesis.	Phosphatidylinositol 4,5-Diphosphate	86-90	coagulation factor II, thrombin	Homo sapiens	33-41	
2412047-4	1985	The secretion of serotonin probably is triggered by products of thrombin-induced activation of the phospholipase C directed against PI-P2.	Phosphatidylinositol 4,5-Diphosphate	132-137	coagulation factor II, thrombin	Homo sapiens	64-72	
6324792-1	1984	Thrombin stimulation of human blood platelets caused an extensive (up to 45%) and rapid (5-10 s) decline in endogenous phosphatidylinositol 4,5-bisphosphate (PI-P2).	Phosphatidylinositol 4,5-Diphosphate	119-156	coagulation factor II, thrombin	Homo sapiens	0-8	
6324792-1	1984	Thrombin stimulation of human blood platelets caused an extensive (up to 45%) and rapid (5-10 s) decline in endogenous phosphatidylinositol 4,5-bisphosphate (PI-P2).	Phosphatidylinositol 4,5-Diphosphate	158-163	coagulation factor II, thrombin	Homo sapiens	0-8	
6324792-4	1984	Thrombin-induced decreases in PI-P2 content could account for release of sufficient membrane-bound Ca to raise cytoplasmic free [Ca2+] to 1-2 microM, supporting the hypothesis that PI-P2 represents the Ca-binding site involved in the stimulus-dependent increase in cytoplasmic Ca2+ evoked by receptor-ligand interactions.	Phosphatidylinositol 4,5-Diphosphate	30-35	coagulation factor II, thrombin	Homo sapiens	0-8	
6324792-4	1984	Thrombin-induced decreases in PI-P2 content could account for release of sufficient membrane-bound Ca to raise cytoplasmic free [Ca2+] to 1-2 microM, supporting the hypothesis that PI-P2 represents the Ca-binding site involved in the stimulus-dependent increase in cytoplasmic Ca2+ evoked by receptor-ligand interactions.	Phosphatidylinositol 4,5-Diphosphate	181-186	coagulation factor II, thrombin	Homo sapiens	0-8	
6296123-1	1983	The addition of thrombin to human platelets prelabeled with 32Pi led to significant loss of radioactivity in phosphatidylinositol 4,5-bisphosphate within 5 s, followed by recovery or even increase by 2 min.	Phosphatidylinositol 4,5-Diphosphate	109-146	coagulation factor II, thrombin	Homo sapiens	16-24	
6301436-2	1983	The addition of thrombin to [3H]glycerol-labeled platelets induced an initial loss and a subsequent increase of the radioactivity in phosphatidylinositol-4,5-bisphosphate (TPI) without any significant change in phosphatidylinositol-4-phosphate (DPI).	Phosphatidylinositol 4,5-Diphosphate	133-170	coagulation factor II, thrombin	Homo sapiens	16-24