PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25483581-0 2014 Is PIP2 involved in the insulin effect? Phosphatidylinositol 4,5-Diphosphate 3-7 insulin Homo sapiens 24-31 21712361-2 2011 Evidence reveals a hidden cost of hyperinsulinemia on plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate (PIP(2))-regulated filamentous actin (F-actin) structure, components critical to the normal operation of the insulin-regulated glucose transport system. Phosphatidylinositol 4,5-Diphosphate 75-112 insulin Homo sapiens 39-46 21712361-2 2011 Evidence reveals a hidden cost of hyperinsulinemia on plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate (PIP(2))-regulated filamentous actin (F-actin) structure, components critical to the normal operation of the insulin-regulated glucose transport system. Phosphatidylinositol 4,5-Diphosphate 114-120 insulin Homo sapiens 39-46 21712361-6 2011 In addition to protecting against the insulin-induced membrane/cytoskeletal abnormality and insulin-resistant state, exogenous PIP(2) corrected the GlcN-induced insult on these parameters. Phosphatidylinositol 4,5-Diphosphate 127-133 insulin Homo sapiens 92-99 21097841-7 2011 Insulin treatment promoted an increase in levels of the signaling phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) in plasmalemmal caveolae. Phosphatidylinositol 4,5-Diphosphate 79-116 insulin Homo sapiens 0-7 17379645-0 2007 Insulin potentiates Ca2+ signaling and phosphatidylinositol 4,5-bisphosphate hydrolysis induced by Gq protein-coupled receptor agonists through an mTOR-dependent pathway. Phosphatidylinositol 4,5-Diphosphate 39-76 insulin Homo sapiens 0-7 20503521-1 2010 Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actin. Phosphatidylinositol 4,5-Diphosphate 100-137 insulin Homo sapiens 52-59 19729450-0 2009 Cholesterol regulates glucose-stimulated insulin secretion through phosphatidylinositol 4,5-bisphosphate. Phosphatidylinositol 4,5-Diphosphate 67-104 insulin Homo sapiens 41-48 19729450-3 2009 Here, we show that in cultured beta-cells, cholesterol acts through phosphatidylinositol 4,5-bisphosphate (PIP(2)) to regulate actin dynamics, plasma membrane potential, and glucose-stimulated insulin secretion. Phosphatidylinositol 4,5-Diphosphate 68-105 insulin Homo sapiens 193-200 19036880-0 2009 Hexosamine biosynthesis pathway flux contributes to insulin resistance via altering membrane phosphatidylinositol 4,5-bisphosphate and cortical filamentous actin. Phosphatidylinositol 4,5-Diphosphate 93-130 insulin Homo sapiens 52-59 19036880-1 2009 We recently found that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2))-regulated filamentous actin (F-actin) polymerization was diminished in hyperinsulinemic cell culture models of insulin resistance. Phosphatidylinositol 4,5-Diphosphate 39-76 insulin Homo sapiens 162-169 17379645-5 2007 Real-time imaging of single cells showed that treatment with insulin enhances the rate and magnitude of phosphatidylinositol 4,5-bisphosphate hydrolysis and generation of inositol 1,4,5-trisphosphate in response to GPCR stimulation. Phosphatidylinositol 4,5-Diphosphate 104-141 insulin Homo sapiens 61-68 7926350-9 1994 These results suggest that sulphonylureas and insulin induce suppression of thrombin-induced activation of phospholipase C, which mediates hydrolysis of PIP and PIP2 and production of PA, which leads to inhibition of platelet aggregation. Phosphatidylinositol 4,5-Diphosphate 161-165 insulin Homo sapiens 46-53 15919791-0 2005 Phosphatidylinositol 4,5-bisphosphate reverses endothelin-1-induced insulin resistance via an actin-dependent mechanism. Phosphatidylinositol 4,5-Diphosphate 0-37 insulin Homo sapiens 68-75 15277534-0 2004 Protective effect of phosphatidylinositol 4,5-bisphosphate against cortical filamentous actin loss and insulin resistance induced by sustained exposure of 3T3-L1 adipocytes to insulin. Phosphatidylinositol 4,5-Diphosphate 21-58 insulin Homo sapiens 103-110 15277534-0 2004 Protective effect of phosphatidylinositol 4,5-bisphosphate against cortical filamentous actin loss and insulin resistance induced by sustained exposure of 3T3-L1 adipocytes to insulin. Phosphatidylinositol 4,5-Diphosphate 21-58 insulin Homo sapiens 176-183 15277534-7 2004 Using a PIP(2) delivery system, we replenished plasma membrane PIP(2) in cells following the sustained insulin treatment and observed a restoration in cortical F-actin and insulin responsiveness. Phosphatidylinositol 4,5-Diphosphate 8-14 insulin Homo sapiens 103-110 15277534-7 2004 Using a PIP(2) delivery system, we replenished plasma membrane PIP(2) in cells following the sustained insulin treatment and observed a restoration in cortical F-actin and insulin responsiveness. Phosphatidylinositol 4,5-Diphosphate 8-14 insulin Homo sapiens 172-179 15277534-7 2004 Using a PIP(2) delivery system, we replenished plasma membrane PIP(2) in cells following the sustained insulin treatment and observed a restoration in cortical F-actin and insulin responsiveness. Phosphatidylinositol 4,5-Diphosphate 63-69 insulin Homo sapiens 103-110 15277534-7 2004 Using a PIP(2) delivery system, we replenished plasma membrane PIP(2) in cells following the sustained insulin treatment and observed a restoration in cortical F-actin and insulin responsiveness. Phosphatidylinositol 4,5-Diphosphate 63-69 insulin Homo sapiens 172-179 15024008-3 2004 Here, we demonstrate that neomycin, a drug that masks the cellular substrate of PI3K, phosphatidylinositol 4,5-bisphosphate (PIP), prevents wortmannin inhibition of insulin-stimulated (2)Glut4 translocation and glucose transport without activating protein kinase B, a downstream effector of PI3K. Phosphatidylinositol 4,5-Diphosphate 86-123 insulin Homo sapiens 165-172 2993299-10 1985 From these data we conclude that insulin stimulates the de novo synthesis of phosphatidylinositol and phosphatidylinositol 4,5-biphosphate, but has no effect on phosphoinositide breakdown. Phosphatidylinositol 4,5-Diphosphate 102-138 insulin Homo sapiens 33-40 32593716-2 2020 It has been implicated that phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] is involved in insulin-regulated GLUT4 translocation in adipocytes. Phosphatidylinositol 4,5-Diphosphate 28-65 insulin Homo sapiens 93-100 2993299-3 1985 Insulin increased the labeling of phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate but not phosphatidylinositol 4-monophosphate in cells which had been preincubated with [3H]inositol for 90 min. Phosphatidylinositol 4,5-Diphosphate 59-96 insulin Homo sapiens 0-7 31091439-1 2019 Insulin stimulates the conversion of phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) to phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3), which mediates downstream cellular responses. Phosphatidylinositol 4,5-Diphosphate 37-74 insulin Homo sapiens 0-7 30717198-1 2019 We previously demonstrated that an aspalathin-enriched green rooibos extract (GRE) reversed palmitate-induced insulin resistance in C2C12 skeletal muscle and 3T3-L1 fat cells by modulating key effectors of insulin signalling such as phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT) and AMP-activated protein kinase (AMPK). Phosphatidylinositol 4,5-Diphosphate 233-270 insulin Homo sapiens 206-213 27447049-0 2016 Plasma Membrane Phosphatidylinositol 4,5-Bisphosphate Regulates Ca(2+)-Influx and Insulin Secretion from Pancreatic beta Cells. Phosphatidylinositol 4,5-Diphosphate 16-53 insulin Homo sapiens 82-89