PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12900409-11 2003 Our findings suggest that an Akt-mediated cell survival pathway is compromised by the diminished availability of PIP2 elicited by pathological levels of Gq activity. Phosphatidylinositol 4,5-Diphosphate 113-117 thymoma viral proto-oncogene 1 Mus musculus 29-32 33276499-3 2020 PTEN negatively regulates PI3K/AKT signalling by dephosphorylating PtdIns(3,4,5)P3 to form PtdIns(4,5)P2. Phosphatidylinositol 4,5-Diphosphate 91-104 thymoma viral proto-oncogene 1 Mus musculus 31-34 10526670-3 1999 Rac causes uncapping of actin filaments (F-actin) at the plus-ends, through phosphatidylinositol 4,5 bisphosphate (PIP2), and eventually induces membrane ruffling. Phosphatidylinositol 4,5-Diphosphate 76-113 thymoma viral proto-oncogene 1 Mus musculus 0-3 10526670-3 1999 Rac causes uncapping of actin filaments (F-actin) at the plus-ends, through phosphatidylinositol 4,5 bisphosphate (PIP2), and eventually induces membrane ruffling. Phosphatidylinositol 4,5-Diphosphate 115-119 thymoma viral proto-oncogene 1 Mus musculus 0-3 30985214-6 2019 In addition, Cry1 knockdown inhibited the phosphorylation of AKT kinase (AKT) and extracellular signal-regulated kinase (ERK), which suppressed the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)-AKT and mitogen-activated protein kinase (MAPK)-ERK signaling pathways. Phosphatidylinositol 4,5-Diphosphate 148-185 thymoma viral proto-oncogene 1 Mus musculus 61-64 30985214-6 2019 In addition, Cry1 knockdown inhibited the phosphorylation of AKT kinase (AKT) and extracellular signal-regulated kinase (ERK), which suppressed the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)-AKT and mitogen-activated protein kinase (MAPK)-ERK signaling pathways. Phosphatidylinositol 4,5-Diphosphate 148-185 thymoma viral proto-oncogene 1 Mus musculus 73-76 30985214-6 2019 In addition, Cry1 knockdown inhibited the phosphorylation of AKT kinase (AKT) and extracellular signal-regulated kinase (ERK), which suppressed the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)-AKT and mitogen-activated protein kinase (MAPK)-ERK signaling pathways. Phosphatidylinositol 4,5-Diphosphate 148-185 thymoma viral proto-oncogene 1 Mus musculus 73-76 27098694-3 2016 Akt/PKB, a key effector of phosphatidylinositol-4,5-bisphosphate 3-kinase 1A, was previously implicated in CNS, but not PNS myelination. Phosphatidylinositol 4,5-Diphosphate 27-64 thymoma viral proto-oncogene 1 Mus musculus 0-7 28450417-5 2017 Mechanistically, the GDF11-mediated protective effects could be attributed to the activation of transforming growth factor-beta/Smad2 and phosphatidylinositol-4,5-bisphosphate 3-kinase-AKT-FoxO1 signaling. Phosphatidylinositol 4,5-Diphosphate 138-175 thymoma viral proto-oncogene 1 Mus musculus 185-188 29035165-3 2017 PI3Ks phosphorylate phosphatidylinositol 4,5-biphosphate (PIP2) yielding phosphatidylinositol 3, 4, 5 triphosphate (PIP3) which in turn activate AKT kinase (serine/threonine kinase), the central enzyme in regulation of metabolic functions. Phosphatidylinositol 4,5-Diphosphate 20-56 thymoma viral proto-oncogene 1 Mus musculus 145-148 29035165-3 2017 PI3Ks phosphorylate phosphatidylinositol 4,5-biphosphate (PIP2) yielding phosphatidylinositol 3, 4, 5 triphosphate (PIP3) which in turn activate AKT kinase (serine/threonine kinase), the central enzyme in regulation of metabolic functions. Phosphatidylinositol 4,5-Diphosphate 58-62 thymoma viral proto-oncogene 1 Mus musculus 145-148 25737250-2 2015 ROS, such as hydrogen peroxide, have the potential to affect signal transduction pathways such as the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3 K)/Akt pathway that regulates protein synthesis. Phosphatidylinositol 4,5-Diphosphate 102-139 thymoma viral proto-oncogene 1 Mus musculus 157-160 25972378-11 2015 Thus, our data further expand the list of genes encoding components of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT signalling cascade that are disrupted in human overgrowth conditions. Phosphatidylinositol 4,5-Diphosphate 75-112 thymoma viral proto-oncogene 1 Mus musculus 129-132 23749168-4 2013 Exogenous PIP3 supplementation (1, 5, or 10 nM) increased the phosphorylation of AKT and PKCzeta/lambda, which in turn upregulated GLUT4 total protein expression as well as its surface expression, glucose uptake, and glucose utilization in cells exposed to HG (25 mM); however, PIP2 had no effect. Phosphatidylinositol 4,5-Diphosphate 278-282 thymoma viral proto-oncogene 1 Mus musculus 81-84 24658595-2 2014 By acting as a unique lipid phosphatase converting phosphatidylinositol-3,4,5,- trisphosphate (PIP3) to phosphatidylinositol-4,5,-bisphosphate (PIP2), phosphatase and tensin homolog (PTEN) acts as the major cellular suppressor of PI3K signaling and AKT activation. Phosphatidylinositol 4,5-Diphosphate 104-142 thymoma viral proto-oncogene 1 Mus musculus 249-252 24658595-2 2014 By acting as a unique lipid phosphatase converting phosphatidylinositol-3,4,5,- trisphosphate (PIP3) to phosphatidylinositol-4,5,-bisphosphate (PIP2), phosphatase and tensin homolog (PTEN) acts as the major cellular suppressor of PI3K signaling and AKT activation. Phosphatidylinositol 4,5-Diphosphate 144-148 thymoma viral proto-oncogene 1 Mus musculus 249-252 21444720-9 2011 We propose Rac-led inhibition of PLD2 function is due to sterical interference of Rac with PLD2"s PH binding site to the membrane and deprivation of the PIP(2). Phosphatidylinositol 4,5-Diphosphate 153-159 thymoma viral proto-oncogene 1 Mus musculus 11-14 20841379-0 2010 Rac controls PIP5K localisation and PtdIns(4,5)P2 synthesis, which modulates vinculin localisation and neurite dynamics. Phosphatidylinositol 4,5-Diphosphate 36-49 thymoma viral proto-oncogene 1 Mus musculus 0-3 20841379-6 2010 Using this mutant, we show that Rac controls the plasma membrane localisation of PIP5Kbeta and thereby the localised synthesis of PtdIns(4,5)P2 required to induce neurite retraction. Phosphatidylinositol 4,5-Diphosphate 130-143 thymoma viral proto-oncogene 1 Mus musculus 32-35