PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21760611-4 2011 We show that CD95 promotes Tyr 783 phosphorylation of phospholipase C-gamma1 through the platelet-derived growth factor receptor-beta, resulting in ligand-stimulated phosphatidylinositol (4,5)-bisphosphate (PIP(2)) hydrolysis. Phosphatidylinositol 4,5-Diphosphate 166-205 phospholipase C gamma 1 Homo sapiens 54-76 24117814-12 2013 Inositol cleavage by PLCgamma1 simultaneously triggers both endoplasmic reticulum store release and diacylglycerol-dependent microtubule organizing center reorientation, while depleting the pool of phosphatidylinositol-4,5-bisphosphate, an activator of multiple actin-regulatory proteins. Phosphatidylinositol 4,5-Diphosphate 198-235 phospholipase C gamma 1 Homo sapiens 21-30 14724086-1 2004 OBJECTIVE: To investigate the dynamic characteristics of lipid phosphatidylinositol (4,5)-bisphosphate (PIP(2)) in plasma membrane hydrolyzed by phospholipase C-gamma1 in epidermal growth factor receptor(EGFR)-mediated signal pathway. Phosphatidylinositol 4,5-Diphosphate 63-102 phospholipase C gamma 1 Homo sapiens 145-167 19952372-5 2009 These events were associated with the impaired translocation of phosphorylated phospholipase C-gamma1 (PLC-gamma1) to the actin cytoskeleton, which was required to bring PLC-gamma1 close to its substrate phosphatidylinositol 4,5-bisphosphate, and were reversed by reconstitution of cells with RIAM. Phosphatidylinositol 4,5-Diphosphate 204-241 phospholipase C gamma 1 Homo sapiens 79-101 19952372-5 2009 These events were associated with the impaired translocation of phosphorylated phospholipase C-gamma1 (PLC-gamma1) to the actin cytoskeleton, which was required to bring PLC-gamma1 close to its substrate phosphatidylinositol 4,5-bisphosphate, and were reversed by reconstitution of cells with RIAM. Phosphatidylinositol 4,5-Diphosphate 204-241 phospholipase C gamma 1 Homo sapiens 103-113 15607032-3 2004 We previously reported that the split PH domain of PLC-gamma1 binds to phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) (Chang et al., 2002). Phosphatidylinositol 4,5-Diphosphate 117-154 phospholipase C gamma 1 Homo sapiens 51-61 14993293-2 2004 Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma1 (PLC-gamma1)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis, as we showed previously for c-Abl. Phosphatidylinositol 4,5-Diphosphate 169-206 phospholipase C gamma 1 Homo sapiens 124-146 14993293-2 2004 Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma1 (PLC-gamma1)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis, as we showed previously for c-Abl. Phosphatidylinositol 4,5-Diphosphate 169-206 phospholipase C gamma 1 Homo sapiens 148-158 14993293-2 2004 Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma1 (PLC-gamma1)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis, as we showed previously for c-Abl. Phosphatidylinositol 4,5-Diphosphate 208-212 phospholipase C gamma 1 Homo sapiens 124-146 14993293-2 2004 Here, we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma1 (PLC-gamma1)-mediated phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis, as we showed previously for c-Abl. Phosphatidylinositol 4,5-Diphosphate 208-212 phospholipase C gamma 1 Homo sapiens 148-158 16648366-3 2006 Therefore, we cloned cDNA for a pollen-expressed phosphatidylinositol 4,5-bisphosphate (PtdInsP2)-cleaving phospholipase C (PLC) from Petunia inflata, named Pet PLC1. Phosphatidylinositol 4,5-Diphosphate 49-86 phospholipase C gamma 1 Homo sapiens 161-165 16648366-3 2006 Therefore, we cloned cDNA for a pollen-expressed phosphatidylinositol 4,5-bisphosphate (PtdInsP2)-cleaving phospholipase C (PLC) from Petunia inflata, named Pet PLC1. Phosphatidylinositol 4,5-Diphosphate 88-96 phospholipase C gamma 1 Homo sapiens 161-165 14724086-0 2004 [Mathematical model of epidermal growth factor receptor-mediated lipid phosphatidylinositol(4,5)-bisphosphate hydrolyzation by phospholipase C-gamma1 activity]. Phosphatidylinositol 4,5-Diphosphate 71-109 phospholipase C gamma 1 Homo sapiens 127-149 14724086-1 2004 OBJECTIVE: To investigate the dynamic characteristics of lipid phosphatidylinositol (4,5)-bisphosphate (PIP(2)) in plasma membrane hydrolyzed by phospholipase C-gamma1 in epidermal growth factor receptor(EGFR)-mediated signal pathway. Phosphatidylinositol 4,5-Diphosphate 104-110 phospholipase C gamma 1 Homo sapiens 145-167 10700379-7 2000 Kinetic analysis revealed that the mole fraction of phosphatidylinositol 4,5-bisphosphate (PIP(2)) that resulted in half-maximal PIP(2) hydrolysis (S(0.5)) was lower for proteolyzed than uncleaved phospholipase C-gamma1 (0.08 mole fraction vs 0.18 mole fraction of PIP(2)). Phosphatidylinositol 4,5-Diphosphate 52-89 phospholipase C gamma 1 Homo sapiens 197-219 11226408-6 2001 Our findings suggest that, for proper signaling, PLC-gamma1 phosphorylation has to occur at PtdInsP(2)-enriched sites. Phosphatidylinositol 4,5-Diphosphate 92-102 phospholipase C gamma 1 Homo sapiens 49-59 11051096-1 2000 Phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) is the substrate for phosphoinositide-phospholipase C (PLC) and is required for the function of several cardiac cell plasma membrane (sarcolemma, SL) proteins. Phosphatidylinositol 4,5-Diphosphate 0-37 phospholipase C gamma 1 Homo sapiens 75-107 11051096-1 2000 Phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) is the substrate for phosphoinositide-phospholipase C (PLC) and is required for the function of several cardiac cell plasma membrane (sarcolemma, SL) proteins. Phosphatidylinositol 4,5-Diphosphate 0-37 phospholipase C gamma 1 Homo sapiens 109-112 11051096-1 2000 Phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) is the substrate for phosphoinositide-phospholipase C (PLC) and is required for the function of several cardiac cell plasma membrane (sarcolemma, SL) proteins. Phosphatidylinositol 4,5-Diphosphate 39-52 phospholipase C gamma 1 Homo sapiens 75-107 11051096-1 2000 Phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) is the substrate for phosphoinositide-phospholipase C (PLC) and is required for the function of several cardiac cell plasma membrane (sarcolemma, SL) proteins. Phosphatidylinositol 4,5-Diphosphate 39-52 phospholipase C gamma 1 Homo sapiens 109-112 11018473-2 2000 The pH optimum for hydrolysis of phosphatidylinositol 4,5-bisphosphate by phospholipase C-gamma1 was dependent on the mole fraction of substrate in the micelle. Phosphatidylinositol 4,5-Diphosphate 33-70 phospholipase C gamma 1 Homo sapiens 74-96 12652307-4 2003 Decreasing cellular levels of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) by PLC-gamma1-mediated hydrolysis or dephosphorylation by an inositol polyphosphate 5-phosphatase (Inp54) results in increased Abl kinase activity. Phosphatidylinositol 4,5-Diphosphate 30-67 phospholipase C gamma 1 Homo sapiens 87-97 12652307-4 2003 Decreasing cellular levels of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) by PLC-gamma1-mediated hydrolysis or dephosphorylation by an inositol polyphosphate 5-phosphatase (Inp54) results in increased Abl kinase activity. Phosphatidylinositol 4,5-Diphosphate 69-82 phospholipase C gamma 1 Homo sapiens 87-97 11823862-1 2002 Phospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. Phosphatidylinositol 4,5-Diphosphate 49-86 phospholipase C gamma 1 Homo sapiens 0-23 11823862-1 2002 Phospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. Phosphatidylinositol 4,5-Diphosphate 49-86 phospholipase C gamma 1 Homo sapiens 25-36 10692443-1 2000 Upon stimulation of cells with platelet-derived growth factor (PDGF), phospholipase C-gamma1 (PLC-gamma1) binds to the tyrosine-phosphorylated PDGF receptor through one or both of its Src homology 2 (SH2) domains, is phosphorylated by the receptor kinase, and is thereby activated to hydrolyze phosphatidylinositol 4, 5-bisphosphate. Phosphatidylinositol 4,5-Diphosphate 294-332 phospholipase C gamma 1 Homo sapiens 70-92 10692443-1 2000 Upon stimulation of cells with platelet-derived growth factor (PDGF), phospholipase C-gamma1 (PLC-gamma1) binds to the tyrosine-phosphorylated PDGF receptor through one or both of its Src homology 2 (SH2) domains, is phosphorylated by the receptor kinase, and is thereby activated to hydrolyze phosphatidylinositol 4, 5-bisphosphate. Phosphatidylinositol 4,5-Diphosphate 294-332 phospholipase C gamma 1 Homo sapiens 94-104 9716455-1 1998 It is known that platelet-derived growth factor (PDGF) induces the phosphorylation of phospholipase C (PLC) gamma1 and that phosphorylation on tyrosine (Tyr) 783 of PLCgamma1 is essential for phosphatidylinositol 4,5-bisphosphate hydrolyzing activity in vivo, while phosphorylation does not affect the catalytic activity in vitro. Phosphatidylinositol 4,5-Diphosphate 192-229 phospholipase C gamma 1 Homo sapiens 165-174 10672930-1 1999 Phospholipase C-gamma1 (PLC-gamma1) is a lipase that hydrolyzes PIP2 to generate two second messengers, IP3 and DAG. Phosphatidylinositol 4,5-Diphosphate 64-68 phospholipase C gamma 1 Homo sapiens 0-22 10672930-1 1999 Phospholipase C-gamma1 (PLC-gamma1) is a lipase that hydrolyzes PIP2 to generate two second messengers, IP3 and DAG. Phosphatidylinositol 4,5-Diphosphate 64-68 phospholipase C gamma 1 Homo sapiens 24-34 8909300-10 1996 Moreover, the inhibitory effect of profilin on PLC-gamma 1-mediated PtdIns(4,5)P2 hydrolysis is overcome by PtdIns(3,4)P2 and PtdIns(3,4,5)P3 through a combined effect of PLC-gamma 1 activation and preferential profilin binding. Phosphatidylinositol 4,5-Diphosphate 68-81 phospholipase C gamma 1 Homo sapiens 47-58 8909300-10 1996 Moreover, the inhibitory effect of profilin on PLC-gamma 1-mediated PtdIns(4,5)P2 hydrolysis is overcome by PtdIns(3,4)P2 and PtdIns(3,4,5)P3 through a combined effect of PLC-gamma 1 activation and preferential profilin binding. Phosphatidylinositol 4,5-Diphosphate 68-81 phospholipase C gamma 1 Homo sapiens 171-182 8909300-11 1996 This D-3 phosphoinositide-mediated regulation may represent a new mechanism for controlling PtdIns(4,5)P2 turnover by PLC-gamma 1. Phosphatidylinositol 4,5-Diphosphate 92-105 phospholipase C gamma 1 Homo sapiens 118-129 1370476-5 1992 These results suggest that the inhibition of PtdIns 4,5-P2 hydrolysis by PMA and cAMP is attributable to reduced tyrosine phosphorylation of PLC-gamma 1. Phosphatidylinositol 4,5-Diphosphate 45-58 phospholipase C gamma 1 Homo sapiens 141-152 8641669-7 1996 His321 inhibited phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis by phospholipase C gamma 1 more strongly in vitro than did wild-type gelsolin because of its higher binding capacity to phosphoinositide. Phosphatidylinositol 4,5-Diphosphate 17-54 phospholipase C gamma 1 Homo sapiens 76-99 8641669-7 1996 His321 inhibited phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis by phospholipase C gamma 1 more strongly in vitro than did wild-type gelsolin because of its higher binding capacity to phosphoinositide. Phosphatidylinositol 4,5-Diphosphate 56-60 phospholipase C gamma 1 Homo sapiens 76-99 7822789-5 1995 The substrate for PLC gamma 1, phosphatidylinositol 4,5-bisphosphate (PIP2), is hydrolyzed to the protein kinase C activator diacylglycerol and inositol 1,4,5-triphosphate (IP3), which promotes calcium release from the endoplasmic reticulum. Phosphatidylinositol 4,5-Diphosphate 31-68 phospholipase C gamma 1 Homo sapiens 18-29 7822789-5 1995 The substrate for PLC gamma 1, phosphatidylinositol 4,5-bisphosphate (PIP2), is hydrolyzed to the protein kinase C activator diacylglycerol and inositol 1,4,5-triphosphate (IP3), which promotes calcium release from the endoplasmic reticulum. Phosphatidylinositol 4,5-Diphosphate 70-74 phospholipase C gamma 1 Homo sapiens 18-29 1313007-1 1992 The effective resolution of human platelet cytosolic phosphoinositide-phospholipase C (PLC) revealed five distinct activity peaks by Q-Sepharose and heparin-Sepharose column chromatographies when assayed using phosphatidylinositol (PI) and phosphatidylinositol 4,5-bisphosphate (PIP2). Phosphatidylinositol 4,5-Diphosphate 240-277 phospholipase C gamma 1 Homo sapiens 53-85 1313007-1 1992 The effective resolution of human platelet cytosolic phosphoinositide-phospholipase C (PLC) revealed five distinct activity peaks by Q-Sepharose and heparin-Sepharose column chromatographies when assayed using phosphatidylinositol (PI) and phosphatidylinositol 4,5-bisphosphate (PIP2). Phosphatidylinositol 4,5-Diphosphate 240-277 phospholipase C gamma 1 Homo sapiens 87-90 1313007-1 1992 The effective resolution of human platelet cytosolic phosphoinositide-phospholipase C (PLC) revealed five distinct activity peaks by Q-Sepharose and heparin-Sepharose column chromatographies when assayed using phosphatidylinositol (PI) and phosphatidylinositol 4,5-bisphosphate (PIP2). Phosphatidylinositol 4,5-Diphosphate 279-283 phospholipase C gamma 1 Homo sapiens 53-85 1313007-1 1992 The effective resolution of human platelet cytosolic phosphoinositide-phospholipase C (PLC) revealed five distinct activity peaks by Q-Sepharose and heparin-Sepharose column chromatographies when assayed using phosphatidylinositol (PI) and phosphatidylinositol 4,5-bisphosphate (PIP2). Phosphatidylinositol 4,5-Diphosphate 279-283 phospholipase C gamma 1 Homo sapiens 87-90 1313007-11 1992 The inhibitory effect of gelsolin on PIP2-hydrolysis by PLC-gamma 1 was diminished by a large amount of PIP2 substrate. Phosphatidylinositol 4,5-Diphosphate 37-41 phospholipase C gamma 1 Homo sapiens 56-67 1313007-12 1992 These results suggested that the inhibition of PLC by gelsolin is due to sequestration of substrate PIP2 by its competitive binding. Phosphatidylinositol 4,5-Diphosphate 100-104 phospholipase C gamma 1 Homo sapiens 47-50 7487955-5 1995 Tyrosine phosphorylation of PLC gamma 1 correlated with the time- and concentration-dependent decrease in the mass of membrane phosphatidylinositol 4,5-bisphosphate (PIP2) and the increase in the epithelial concentration of inositol 1,4,5-trisphosphate (IP3). Phosphatidylinositol 4,5-Diphosphate 127-164 phospholipase C gamma 1 Homo sapiens 28-39 7487955-5 1995 Tyrosine phosphorylation of PLC gamma 1 correlated with the time- and concentration-dependent decrease in the mass of membrane phosphatidylinositol 4,5-bisphosphate (PIP2) and the increase in the epithelial concentration of inositol 1,4,5-trisphosphate (IP3). Phosphatidylinositol 4,5-Diphosphate 166-170 phospholipase C gamma 1 Homo sapiens 28-39 7673143-3 1995 By binding to clusters of PIP2, profilin is able to inhibit the hydrolysis of PIP2 by phospholipase C gamma 1 (PLC gamma 1). Phosphatidylinositol 4,5-Diphosphate 26-30 phospholipase C gamma 1 Homo sapiens 86-109 7673143-3 1995 By binding to clusters of PIP2, profilin is able to inhibit the hydrolysis of PIP2 by phospholipase C gamma 1 (PLC gamma 1). Phosphatidylinositol 4,5-Diphosphate 26-30 phospholipase C gamma 1 Homo sapiens 111-122 7673143-3 1995 By binding to clusters of PIP2, profilin is able to inhibit the hydrolysis of PIP2 by phospholipase C gamma 1 (PLC gamma 1). Phosphatidylinositol 4,5-Diphosphate 78-82 phospholipase C gamma 1 Homo sapiens 86-109 7673143-3 1995 By binding to clusters of PIP2, profilin is able to inhibit the hydrolysis of PIP2 by phospholipase C gamma 1 (PLC gamma 1). Phosphatidylinositol 4,5-Diphosphate 78-82 phospholipase C gamma 1 Homo sapiens 111-122 7673143-8 1995 When tested for their relative abilities to inhibit the hydrolysis of PIP2 by PLC gamma 1, most of the mutants were indistinguishable from wild-type profilin. Phosphatidylinositol 4,5-Diphosphate 70-74 phospholipase C gamma 1 Homo sapiens 78-89 7673143-12 1995 Taken together with the finding that mutating residue 88 resulted in decreased inhibition of PLC gamma 1 activity, these data provide strong evidence that this region of human profilin represents an important binding site for PIP2. Phosphatidylinositol 4,5-Diphosphate 226-230 phospholipase C gamma 1 Homo sapiens 93-104 8223875-10 1993 Our data suggest that in HPB-ALL cells the production of DAG following CD3-antigen cross-linking can be fully accounted for by the selective coupling of the TCR to breakdown of phosphatidylinositol-(4,5)-bisphosphate as the result of phospholipase C gamma 1 activation. Phosphatidylinositol 4,5-Diphosphate 177-216 phospholipase C gamma 1 Homo sapiens 234-257 1644792-7 1992 Like other mammalian PLC isoforms, including PLC-beta 1, the catalytic activity of PLC-beta 2 was entirely dependent on Ca2+, and PLC-beta 2 preferred phosphatidyl-inositol 4,5-bisphosphate to phosphatidylinositol as substrate. Phosphatidylinositol 4,5-Diphosphate 151-189 phospholipase C gamma 1 Homo sapiens 21-24 31953353-2 2020 In this study, to our knowledge, we uncover that ORP5L interacts physically with PLCgamma1 in T cells, extracts PIP2 from the plasma membrane via its ORD domain (OSBP-related domain), presents it to PLCgamma1 (enabling IP3 generation), and eventually maintains intracellular Ca2+ homeostasis. Phosphatidylinositol 4,5-Diphosphate 112-116 phospholipase C gamma 1 Homo sapiens 81-90 2550068-6 1989 mPLC-I, mPLC-II, and PLC-II hydrolyzed both PI and PIP2. Phosphatidylinositol 4,5-Diphosphate 51-55 phospholipase C gamma 1 Homo sapiens 9-15 31953353-2 2020 In this study, to our knowledge, we uncover that ORP5L interacts physically with PLCgamma1 in T cells, extracts PIP2 from the plasma membrane via its ORD domain (OSBP-related domain), presents it to PLCgamma1 (enabling IP3 generation), and eventually maintains intracellular Ca2+ homeostasis. Phosphatidylinositol 4,5-Diphosphate 112-116 phospholipase C gamma 1 Homo sapiens 199-208 30135582-5 2018 Mechanistically, matrix stiffness acts through phospholipase Cgamma1 (PLCgamma1) to influence levels of phosphatidylinositol 4,5-bisphosphate and phosphatidic acid, which activates RAP2 through PDZGEF1 and PDZGEF2 (also known as RAPGEF2 and RAPGEF6). Phosphatidylinositol 4,5-Diphosphate 104-141 phospholipase C gamma 1 Homo sapiens 70-79