PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15046600-5 2004 Btk functions as a shuttle to bring PIP5K to the plasma membrane as a means of stimulating PtdIns(4,5) P2 synthesis. Phosphatidylinositol 4,5-Diphosphate 91-105 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 36-41 19160683-4 2009 Phosphatidylinositol-4-phosphate 5-kinases (PIP5 K) phosphorylate PtdIns4P on the 5-position and constitute the major pathway for the generation of PtdIns(4,5)P2. Phosphatidylinositol 4,5-Diphosphate 148-161 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 0-42 19160683-4 2009 Phosphatidylinositol-4-phosphate 5-kinases (PIP5 K) phosphorylate PtdIns4P on the 5-position and constitute the major pathway for the generation of PtdIns(4,5)P2. Phosphatidylinositol 4,5-Diphosphate 148-161 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 44-50 17245604-4 2007 The synthesis of PIP(2) by phosphoinositide 5-kinase (PIP5K) isoforms is tightly regulated by small GTPases and, interestingly, by PA as well, and the concerted formation of PIP(2) and PA has been shown to mediate receptor-regulated cellular events. Phosphatidylinositol 4,5-Diphosphate 17-23 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 54-59 17245604-4 2007 The synthesis of PIP(2) by phosphoinositide 5-kinase (PIP5K) isoforms is tightly regulated by small GTPases and, interestingly, by PA as well, and the concerted formation of PIP(2) and PA has been shown to mediate receptor-regulated cellular events. Phosphatidylinositol 4,5-Diphosphate 174-180 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 54-59 15923187-1 2005 Fission yeast its3-1 mutant is an allele of the essential gene its3+ that encodes a phosphatidylinositol-4-phosphate 5-kinase (PIP5K) that produces phosphatidylinositol 4,5-bisphosphate. Phosphatidylinositol 4,5-Diphosphate 148-185 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 127-132 27905566-6 2016 Increasing cellular PIP2 levels by co-expression of type 1gamma PI(4)P5-kinase (PIP5K) partially recovered homomeric Kv7.2 R325G channel function. Phosphatidylinositol 4,5-Diphosphate 20-24 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 80-85 26157143-3 2015 We have shown previously that the nuclear form of phosphatidylinositol-4-phosphate 5-kinase 1alpha (PIP5K), the enzyme responsible for phosphatidylinositol 4,5-bisphosphate synthesis, is modified by small ubiquitin-like modifier (SUMO)-1. Phosphatidylinositol 4,5-Diphosphate 135-172 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 100-105 22942276-1 2012 Phosphatidylinositol 4,5-bisphosphate is mostly produced in the cell by phosphatidylinositol-4-phosphate 5-kinases (PIP5K) and has a crucial role in numerous signaling events. Phosphatidylinositol 4,5-Diphosphate 0-37 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 72-114 22942276-1 2012 Phosphatidylinositol 4,5-bisphosphate is mostly produced in the cell by phosphatidylinositol-4-phosphate 5-kinases (PIP5K) and has a crucial role in numerous signaling events. Phosphatidylinositol 4,5-Diphosphate 0-37 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 116-121 19951917-1 2009 Plasmalemmal phosphatidylinositol (PI) 4,5-bisphosphate (PI4,5P(2)) synthesized by PI 4-phosphate (PI4P) 5-kinase (PIP5K) is key to the polymerization of actin that drives chemotaxis and phagocytosis. Phosphatidylinositol 4,5-Diphosphate 35-55 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 115-120 14681219-1 2004 Type I phosphatidylinositol 4-phosphate 5-kinase (PIP5K) catalyzes the formation of the phospholipid, phosphatidylinositol 4,5-bisphosphate (PIP(2)), which is implicated in many cellular processes. Phosphatidylinositol 4,5-Diphosphate 102-139 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 50-55 14681219-4 2004 Here we show that RhoA and Rac1, as well as Cdc42, but not the Ras-like GTPases, RalA and Rap1A, markedly stimulate PIP(2) synthesis by all three PIP5K isoforms expressed in human embryonic kidney 293 cells, both in vitro and in vivo. Phosphatidylinositol 4,5-Diphosphate 116-122 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 146-151 14681219-5 2004 RhoA-stimulated PIP(2) synthesis by the PIP5K isoforms was mediated by the RhoA effector, Rho-kinase. Phosphatidylinositol 4,5-Diphosphate 16-22 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 40-45 14681219-9 2004 In summary, our findings indicate that synthesis of PIP(2) by the three PIP5K isoforms is controlled by RhoA, acting via Rho-kinase, as well as Rac1 and Cdc42, implicating that regulation of PIP(2) synthesis has a central position in signaling by these three Rho GTPases. Phosphatidylinositol 4,5-Diphosphate 52-58 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 72-77 14681219-9 2004 In summary, our findings indicate that synthesis of PIP(2) by the three PIP5K isoforms is controlled by RhoA, acting via Rho-kinase, as well as Rac1 and Cdc42, implicating that regulation of PIP(2) synthesis has a central position in signaling by these three Rho GTPases. Phosphatidylinositol 4,5-Diphosphate 191-197 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 72-77 14614854-5 2003 Upon B cell receptor activation, BTK brings PIP5K to the plasma membrane as a means of generating local PtdIns-4,5-P2 synthesis. Phosphatidylinositol 4,5-Diphosphate 104-117 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 44-49 32438408-6 2020 Local production of PIP2 by PIP5K then recruited TIRAP to the preassembled complexes, which were required for TLR signalosome assembly during DC activation. Phosphatidylinositol 4,5-Diphosphate 20-24 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 28-33 9599410-5 1998 PtdIns 4,5-P2-synthesizing enzymes phosphatidylinositol 4-phosphate 5-kinases (PIP5K) also have kinase activity towards PtdIns 3-P and PtdIns 3,4-P2 forming PtdIns 3,4-P2 and PtdIns 3,4,5-P3 respectively. Phosphatidylinositol 4,5-Diphosphate 0-13 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 35-77 9599410-5 1998 PtdIns 4,5-P2-synthesizing enzymes phosphatidylinositol 4-phosphate 5-kinases (PIP5K) also have kinase activity towards PtdIns 3-P and PtdIns 3,4-P2 forming PtdIns 3,4-P2 and PtdIns 3,4,5-P3 respectively. Phosphatidylinositol 4,5-Diphosphate 0-13 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 79-84 34982154-2 2022 We examined the hypothesis that the scaffolding protein Dishevelled can bind the lipid kinases PI4K and PIP5K, facilitating synthesis of PtdInsP2 directly from PtdIns. Phosphatidylinositol 4,5-Diphosphate 137-145 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 104-109 8955136-1 1996 Phosphatidylinositol-4-phosphate 5-kinases (PIP5K) synthesize phosphatidylinositol-4,5-bisphosphate, a key precursor in phosphoinositide signaling that also regulates some proteins and cellular processes directly. Phosphatidylinositol 4,5-Diphosphate 62-99 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 0-42 8955136-1 1996 Phosphatidylinositol-4-phosphate 5-kinases (PIP5K) synthesize phosphatidylinositol-4,5-bisphosphate, a key precursor in phosphoinositide signaling that also regulates some proteins and cellular processes directly. Phosphatidylinositol 4,5-Diphosphate 62-99 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 44-49 34922306-1 2022 Phosphatidyl inositol (4,5)-bisphosphate (PI(4,5)P2) plays several key roles in human biology and the lipid kinase that produces PI(4,5)P2, PIP5K, has been hypothesized to provide a potential therapeutic target of interest in the treatment of cancers. Phosphatidylinositol 4,5-Diphosphate 0-40 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 140-145 31010098-1 2019 Members of the PIP4K/PIP5K family of proteins, which generate the highly important secondary messenger phosphatidylinositol-4,5-bisphosphate, play central roles in regulating diverse signaling pathways. Phosphatidylinositol 4,5-Diphosphate 103-140 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 21-26 31616009-5 2019 We find a redistribution of the PIP5K family members to endomembrane structures upon PIPKH overexpression that is accompanied by accumulation of PtdIns(4,5)P2 and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). Phosphatidylinositol 4,5-Diphosphate 145-158 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 32-37 31616009-6 2019 PIP5Ks are targeted to membranes in part due to electrostatic interactions; however, the interaction between PIPKH and PIP5K is maintained following hydrolysis of PtdIns(4,5)P2. Phosphatidylinositol 4,5-Diphosphate 163-176 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 0-5