PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20435073-10	2010	AGEs may stimulate PIP5Kgamma to increase PIP2 production, which may enhance AP-2 localisation to clathrin pits, increase clathrin pit formation, enhance NKA cargo recognition by AP-2 and/or stimulate cPLA2alpha activity.	Phosphatidylinositol 4,5-Diphosphate	42-46	transcription factor AP-2 alpha	Homo sapiens	179-183	
32743075-6	2020	AP2 binds cargo and PtdIns(4,5)P 2 (phosphatidylinositol 4,5-bisphosphate)-containing membranes via multiple interfaces, undergoing conformational rearrangement from its cytosolic state.	Phosphatidylinositol 4,5-Diphosphate	36-73	transcription factor AP-2 alpha	Homo sapiens	0-3	
23400998-0	2013	Clathrin and AP2 are required for PtdIns(4,5)P2-mediated formation of LRP6 signalosomes.	Phosphatidylinositol 4,5-Diphosphate	34-47	transcription factor AP-2 alpha	Homo sapiens	13-16	
31313456-2	2019	AP1 binds membranes enriched for phosphatidylinositol 4-phosphate, such as the trans Golgi network, while AP2 associates with phosphatidylinositol 4,5-bisphosphate of the plasma membrane.	Phosphatidylinositol 4,5-Diphosphate	126-163	transcription factor AP-2 alpha	Homo sapiens	106-109	
19287005-2	2009	Instead phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) appears to act as the principal compartmental cue for AP-2 placement at the plasma membrane as well as for the docking of numerous other important clathrin coat components at the nascent bud site.	Phosphatidylinositol 4,5-Diphosphate	8-45	transcription factor AP-2 alpha	Homo sapiens	118-122	
19287005-2	2009	Instead phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) appears to act as the principal compartmental cue for AP-2 placement at the plasma membrane as well as for the docking of numerous other important clathrin coat components at the nascent bud site.	Phosphatidylinositol 4,5-Diphosphate	47-62	transcription factor AP-2 alpha	Homo sapiens	118-122	
18411250-5	2008	Reduction of PM PtdIns(4,5)P(2) levels led to a near complete dissociation of Adaptor protein 2 (AP-2) from the PM but had only a small effect on clathrin assembly.	Phosphatidylinositol 4,5-Diphosphate	16-31	transcription factor AP-2 alpha	Homo sapiens	78-95	
18411250-5	2008	Reduction of PM PtdIns(4,5)P(2) levels led to a near complete dissociation of Adaptor protein 2 (AP-2) from the PM but had only a small effect on clathrin assembly.	Phosphatidylinositol 4,5-Diphosphate	16-31	transcription factor AP-2 alpha	Homo sapiens	97-101	
9889104-3	1998	Specifically, the adaptor protein complex AP2 binds phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), PtdIns(3)P, PtdIns(3,4,5)P3 and inositol phosphates.	Phosphatidylinositol 4,5-Diphosphate	52-89	transcription factor AP-2 alpha	Homo sapiens	42-45	
17035630-3	2006	Mutating the PtdIns(4,5)P2 binding site of alpha, the phosphorylation site of mu2, or the YXXPhi binding site of mu2 impairs AP-2 function, as assayed by transferrin uptake.	Phosphatidylinositol 4,5-Diphosphate	13-26	transcription factor AP-2 alpha	Homo sapiens	125-129	
15916959-0	2005	Phosphatidylinositol-(4,5)-bisphosphate regulates sorting signal recognition by the clathrin-associated adaptor complex AP2.	Phosphatidylinositol 4,5-Diphosphate	0-39	transcription factor AP-2 alpha	Homo sapiens	120-123	
15916959-1	2005	The alpha,beta2,mu2,sigma2 heterotetrameric AP2 complex is recruited exclusively to the phosphatidylinositol-4,5-bisphosphate (PtdIns4,5P(2))-rich plasma membrane where, amongst other roles, it selects motif-containing cargo proteins for incorporation into clathrin-coated vesicles.	Phosphatidylinositol 4,5-Diphosphate	88-125	transcription factor AP-2 alpha	Homo sapiens	44-47	
12119359-2	2002	How precisely AP-2 assembly and cargo protein recognition at sites of endocytosis are regulated has remained unclear, but recent evidence implicates phosphoinositides, in particular phosphatidylinositol (4,5)-bisphosphate (PI[4,5]P2), in these processes.	Phosphatidylinositol 4,5-Diphosphate	182-221	transcription factor AP-2 alpha	Homo sapiens	14-18	
9889104-3	1998	Specifically, the adaptor protein complex AP2 binds phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), PtdIns(3)P, PtdIns(3,4,5)P3 and inositol phosphates.	Phosphatidylinositol 4,5-Diphosphate	91-104	transcription factor AP-2 alpha	Homo sapiens	42-45	
9298980-15	1997	Neomycin, which inhibits endogenous PLD by binding to its cofactor phosphatidylinositol 4,5-bisphosphate, prevents the recruitment of AP-2 not only onto endosomes but also onto the plasma membrane, suggesting that both events are mediated by PLD.	Phosphatidylinositol 4,5-Diphosphate	67-104	transcription factor AP-2 alpha	Homo sapiens	134-138	
35486718-0	2022	FCHO controls AP2"s initiating role in endocytosis through a PtdIns(4,5)P2-dependent switch.	Phosphatidylinositol 4,5-Diphosphate	61-74	transcription factor AP-2 alpha	Homo sapiens	14-17