PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6298203-0 1983 Stimulation of phosphatidylinositol 4,5-bisphosphate hydrolysis in hepatocytes by vasopressin. Phosphatidylinositol 4,5-Diphosphate 15-52 arginine vasopressin Rattus norvegicus 82-93 8545053-4 1995 AVP induced a significant increase in 32P labeling of PI, PIP and PIP2. Phosphatidylinositol 4,5-Diphosphate 66-70 arginine vasopressin Rattus norvegicus 0-3 15616193-9 2005 In addition, AVP induced a PLD-dependent neosynthesis of phosphatidylinositol 4,5-bisphosphate (PIP2), which also was accumulated along actin fibers. Phosphatidylinositol 4,5-Diphosphate 57-94 arginine vasopressin Rattus norvegicus 13-16 15616193-9 2005 In addition, AVP induced a PLD-dependent neosynthesis of phosphatidylinositol 4,5-bisphosphate (PIP2), which also was accumulated along actin fibers. Phosphatidylinositol 4,5-Diphosphate 96-100 arginine vasopressin Rattus norvegicus 13-16 8545053-5 1995 The V1 receptor site(s) blocker for AVP abolished enhanced 32P labeling of PIP and PIP2. Phosphatidylinositol 4,5-Diphosphate 83-87 arginine vasopressin Rattus norvegicus 36-39 2170380-3 1990 There have been few studies in fibroblasts which characterize the pattern and relationship of phosphatidylinositol 4,5-bisphosphate (PIP2) and non-phosphoinositide hydrolysis elicited by VP. Phosphatidylinositol 4,5-Diphosphate 94-131 arginine vasopressin Rattus norvegicus 187-189 2170380-13 1990 These data demonstrate that VP elicits the coordinated hydrolysis of PIP2 by phospholipase C and PC hydrolysis by phospholipase D. This event results in the prolonged generation of PA and biphasic formation of DG. Phosphatidylinositol 4,5-Diphosphate 69-73 arginine vasopressin Rattus norvegicus 28-30 2170380-3 1990 There have been few studies in fibroblasts which characterize the pattern and relationship of phosphatidylinositol 4,5-bisphosphate (PIP2) and non-phosphoinositide hydrolysis elicited by VP. Phosphatidylinositol 4,5-Diphosphate 133-137 arginine vasopressin Rattus norvegicus 187-189 2170380-4 1990 Here we demonstrate that VP-induced PIP2 hydrolysis is closely accompanied by phosphatidylcholine (PC) degradation by phospholipase D. Cells prelabeled with [3H]arachidonic acid showed rapid formation and diminution of [3H]diacylglycerol (DG) (5-15s) when treated with VP; this was accompanied by a reduction in polyphosphoinositide radioactivity. Phosphatidylinositol 4,5-Diphosphate 36-40 arginine vasopressin Rattus norvegicus 25-27 2170380-4 1990 Here we demonstrate that VP-induced PIP2 hydrolysis is closely accompanied by phosphatidylcholine (PC) degradation by phospholipase D. Cells prelabeled with [3H]arachidonic acid showed rapid formation and diminution of [3H]diacylglycerol (DG) (5-15s) when treated with VP; this was accompanied by a reduction in polyphosphoinositide radioactivity. Phosphatidylinositol 4,5-Diphosphate 36-40 arginine vasopressin Rattus norvegicus 269-271 2538365-1 1989 Stimulation of vasopressin (V1) receptors of rat aortic smooth muscle cells (A-10, ATCC CRL 1476) results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) with the mobilization of intracellular calcium. Phosphatidylinositol 4,5-Diphosphate 127-164 arginine vasopressin Rattus norvegicus 15-26 2180488-10 1990 A similar inhibitory effect of prior insulin exposure on the transient activation by vasopressin of exogenous phosphatidylinositol 4,5-bisphosphate breakdown by hepatocyte homogenates was also seen. Phosphatidylinositol 4,5-Diphosphate 110-147 arginine vasopressin Rattus norvegicus 85-96 2538365-1 1989 Stimulation of vasopressin (V1) receptors of rat aortic smooth muscle cells (A-10, ATCC CRL 1476) results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) with the mobilization of intracellular calcium. Phosphatidylinositol 4,5-Diphosphate 166-170 arginine vasopressin Rattus norvegicus 15-26 6315708-1 1983 Vasopressin stimulated a 40% decrease in [32P]phosphatidylinositol 4,5-bisphosphate and a 15% decrease in [32P]phosphatidylinositol within 30 s of addition to hepatocytes prelabeled for 60 min with 32P. Phosphatidylinositol 4,5-Diphosphate 46-83 arginine vasopressin Rattus norvegicus 0-11 2537241-2 1989 Stimulation of the cells with arginine vasopressin (AVP) (1 microM) for 2 min caused a significant increase in labelled phosphatidic acid and a significant fall in radioactivity in phosphatidylinositol and phosphatidylinositol 4-monophosphate + phosphatidylinositol 4,5-bisphosphate. Phosphatidylinositol 4,5-Diphosphate 245-282 arginine vasopressin Rattus norvegicus 39-50 2537241-2 1989 Stimulation of the cells with arginine vasopressin (AVP) (1 microM) for 2 min caused a significant increase in labelled phosphatidic acid and a significant fall in radioactivity in phosphatidylinositol and phosphatidylinositol 4-monophosphate + phosphatidylinositol 4,5-bisphosphate. Phosphatidylinositol 4,5-Diphosphate 245-282 arginine vasopressin Rattus norvegicus 52-55 2988926-4 1985 Vasopressin also increased the breakdown of phosphatidylinositol-4,5-bisphosphate within 1 min after its addition to the incubation medium. Phosphatidylinositol 4,5-Diphosphate 44-81 arginine vasopressin Rattus norvegicus 0-11 3001064-3 1986 We have found that in WRK-1 cells, vasopressin induces the rapid loss of PIP2 and the accumulation of inositol phosphates. Phosphatidylinositol 4,5-Diphosphate 73-77 arginine vasopressin Rattus norvegicus 35-46 6439189-2 1984 As early as 10s after addition of AVP (10(-6)M) a significant loss of radioactivity from phosphatidylinositol 4,5-bisphosphate but not from phosphatidylinositol 4-phosphate and phosphatidylinositol was observed in cells prelabelled with 32Pi. Phosphatidylinositol 4,5-Diphosphate 89-126 arginine vasopressin Rattus norvegicus 34-37 6330070-7 1984 Addition of vasopressin (200 nM) to the 32P-labeled plasma membranes stimulated the breakdown of 20% of the [32P]PI-P2 present in the plasma membranes in 1 min when assayed under isosmotic conditions in the presence of 2 nM MgCl2 and approximately 200 nM free calcium. Phosphatidylinositol 4,5-Diphosphate 113-118 arginine vasopressin Rattus norvegicus 12-23 6325442-1 1984 Addition of vasopressin to rat hepatocytes prelabeled with myo-[2-3H]inositol resulted in a very rapid decrease [3H]phosphatidylinositol 4,5-bisphosphate (Ptd-Ins-4,5-P2) which was paralleled by increases of up to 3-fold in the levels of [3H]inositol trisphosphate (Ins-P3) and [3H]inositol bisphosphate (Ins-P2). Phosphatidylinositol 4,5-Diphosphate 155-169 arginine vasopressin Rattus norvegicus 12-23 6315708-2 1983 In hepatocytes prelabeled with [3H]inositol for 60 min, vasopressin produced 20% breakdown of phosphatidylinositol and 33% breakdown of phosphatidylinositol 4,5-bisphosphate within 30 s. There was a 40% increase in total phosphatidylinositol 4,5-bisphosphate within 30 s of vasopressin addition. Phosphatidylinositol 4,5-Diphosphate 136-173 arginine vasopressin Rattus norvegicus 56-67 6315708-2 1983 In hepatocytes prelabeled with [3H]inositol for 60 min, vasopressin produced 20% breakdown of phosphatidylinositol and 33% breakdown of phosphatidylinositol 4,5-bisphosphate within 30 s. There was a 40% increase in total phosphatidylinositol 4,5-bisphosphate within 30 s of vasopressin addition. Phosphatidylinositol 4,5-Diphosphate 221-258 arginine vasopressin Rattus norvegicus 56-67 6315708-9 1983 Vasopressin induces a rapid decrease of labeled phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate within 30 s. Phosphatidylinositol 4,5-Diphosphate 73-110 arginine vasopressin Rattus norvegicus 0-11 6309153-0 1983 Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones. Phosphatidylinositol 4,5-Diphosphate 56-93 arginine vasopressin Rattus norvegicus 127-138 6309153-4 1983 The labelling of PtdIns4P and PtdIns(4,5)P2 in cells stimulated with vasopressin or angiotensin initially declines at a rate of 0.5-1.0% per s, reaches a minimum after 1-2 min and then returns towards the initial value. Phosphatidylinositol 4,5-Diphosphate 30-43 arginine vasopressin Rattus norvegicus 69-80