PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15741172-4	2005	MSS4 encodes a phosphatidylinositol-4-phosphate 5-kinase that synthesizes phosphatidylinositol (4,5)-bisphosphate (PI4,5P(2)).	Phosphatidylinositol 4,5-Diphosphate	74-113	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	0-4	
34052862-1	2021	Phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) is generated through phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P) by Mss4p, the only PtdIns phosphate 5-kinase in yeast cells.	Phosphatidylinositol 4,5-Diphosphate	0-37	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	143-148	
14528019-8	2004	sec14, pik1, and mss4 mutants displayed decreased Spo14p PLD activity, whereas absence of Spo14p did not affect phosphoinositide levels in vivo, suggesting that formation of PtdIns(4,5)P2 is important for Spo14p activity.	Phosphatidylinositol 4,5-Diphosphate	174-187	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	17-21	
34052862-1	2021	Phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) is generated through phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P) by Mss4p, the only PtdIns phosphate 5-kinase in yeast cells.	Phosphatidylinositol 4,5-Diphosphate	39-52	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	143-148	
34052862-11	2021	These results suggest that PtdIns(4)P produced by either Pik1p or Stt4p is immediately phosphorylated by Mss4p and converted to PtdIns(4,5)P2 at the plasma membrane.	Phosphatidylinositol 4,5-Diphosphate	128-141	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	105-110	
23781030-3	2013	In the yeast Saccharomyces cerevisiae, the sole phosphatidylinositol-4-phosphate 5-kinase (PI4P5K) Mss4p is essential for generating plasma membrane PtdIns(4,5)P2.	Phosphatidylinositol 4,5-Diphosphate	149-162	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	99-104	
24465216-5	2014	Here we show that PC(O-16:0/2:0) regulates the distribution of the PtdIns(4)P 5-kinase Mss4 and its product PtdIns(4,5)P2 leading to the formation of invaginations at the plasma membrane (PM).	Phosphatidylinositol 4,5-Diphosphate	108-121	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	87-91	
23781030-6	2013	We show that mss4-f12 cells have reduced plasma membrane PtdIns(4,5)P2 levels as well as a defect in its polarized distribution, yet Mss4-f12p is catalytically active in vitro.	Phosphatidylinositol 4,5-Diphosphate	57-70	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	13-17	
17392273-7	2007	Under these conditions PtdIns(4,5)P2 was not detected on vacuole membranes, and vacuole morphology was normal, indicating vacuolar PtdIns(4,5)P2 derives from Mss4p-generated plasma membrane PtdIns(4,5)P2.	Phosphatidylinositol 4,5-Diphosphate	131-144	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	158-163	
19477927-4	2009	Defects in Mss4 function led to actin depolarization, an inhibition of secretion, reduced levels of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)] in membranes, mislocalization of a pleckstrin homology domain fused to green fluorescent protein, and the mislocalization of Cdc42.	Phosphatidylinositol 4,5-Diphosphate	100-137	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	11-15	
18208507-2	2008	PtdIns(4,5)P2 generation at the plasma membrane in yeast is mediated by the kinase Mss4p, but the mechanism underlying the temporal and spatial activation of Mss4p to increase formation of PtdIns(4,5)P2 at appropriate sites is not known.	Phosphatidylinositol 4,5-Diphosphate	0-13	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	83-88	
18208507-2	2008	PtdIns(4,5)P2 generation at the plasma membrane in yeast is mediated by the kinase Mss4p, but the mechanism underlying the temporal and spatial activation of Mss4p to increase formation of PtdIns(4,5)P2 at appropriate sites is not known.	Phosphatidylinositol 4,5-Diphosphate	0-13	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	158-163	
18208507-2	2008	PtdIns(4,5)P2 generation at the plasma membrane in yeast is mediated by the kinase Mss4p, but the mechanism underlying the temporal and spatial activation of Mss4p to increase formation of PtdIns(4,5)P2 at appropriate sites is not known.	Phosphatidylinositol 4,5-Diphosphate	189-202	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	83-88	
18208507-2	2008	PtdIns(4,5)P2 generation at the plasma membrane in yeast is mediated by the kinase Mss4p, but the mechanism underlying the temporal and spatial activation of Mss4p to increase formation of PtdIns(4,5)P2 at appropriate sites is not known.	Phosphatidylinositol 4,5-Diphosphate	189-202	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	158-163	
17392273-7	2007	Under these conditions PtdIns(4,5)P2 was not detected on vacuole membranes, and vacuole morphology was normal, indicating vacuolar PtdIns(4,5)P2 derives from Mss4p-generated plasma membrane PtdIns(4,5)P2.	Phosphatidylinositol 4,5-Diphosphate	131-144	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	158-163	
16856876-7	2006	Yeast phosphatidylinositol 4-phosphate 5-kinases Mss4 and Its3 are involved in resistance against disturbance of sphingolipid biosynthesis and maintenance of cell integrity through the synthesis of PtdIns(4,5)P2 and downstream signalling through the Rom2/Rho2 and Rgf1/Rho pathways.	Phosphatidylinositol 4,5-Diphosphate	198-211	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	49-53	
16316315-3	2006	We have investigated the effects of weak acids on two stress-responsive signalling molecules, PtdIns(3,5)P2 and PtdIns(4,5)P2, which in S. cerevisiae are synthesized by Fab1p and Mss4p respectively.	Phosphatidylinositol 4,5-Diphosphate	112-125	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	179-184	
16738335-10	2006	These findings, in combination with previous work identifying Slm1 and Slm2 as targets of Mss4/phosphatidylinositol 4,5-bisphosphate and TORC2 signaling, suggest that Slm proteins integrate information from a variety of signaling pathways to coordinate the cellular response to heat stress.	Phosphatidylinositol 4,5-Diphosphate	95-132	1-phosphatidylinositol-4-phosphate 5-kinase	Saccharomyces cerevisiae S288C	90-94