PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29277655-0	2018	Phosphatidylinositol 4,5-bisphosphate, cholesterol, and fatty acids modulate the calcium-activated chloride channel TMEM16A (ANO1).	Phosphatidylinositol 4,5-Diphosphate	0-37	anoctamin 1	Homo sapiens	116-123	
33637964-0	2021	Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels.	Phosphatidylinositol 4,5-Diphosphate	9-13	anoctamin 1	Homo sapiens	53-60	
33637964-4	2021	This has been attributed to the requirement of PIP2 for preventing TMEM16A desensitization.	Phosphatidylinositol 4,5-Diphosphate	47-51	anoctamin 1	Homo sapiens	67-74	
33637964-5	2021	Here, atomistic simulations show that specific binding of PIP2 to TMEM16A can lead to spontaneous opening of the permeation pathway in the Ca2+-bound state.	Phosphatidylinositol 4,5-Diphosphate	58-62	anoctamin 1	Homo sapiens	66-73	
29277655-0	2018	Phosphatidylinositol 4,5-bisphosphate, cholesterol, and fatty acids modulate the calcium-activated chloride channel TMEM16A (ANO1).	Phosphatidylinositol 4,5-Diphosphate	0-37	anoctamin 1	Homo sapiens	125-129	
29277655-3	2018	Here we have studied the regulation of TMEM16A by phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), cholesterol, and fatty acids using patch clamp, biochemistry and fluorescence microscopy.	Phosphatidylinositol 4,5-Diphosphate	50-87	anoctamin 1	Homo sapiens	39-46	
31683182-0	2019	Wasted TMEM16A channels are rescued by phosphatidylinositol 4,5-bisphosphate.	Phosphatidylinositol 4,5-Diphosphate	39-76	anoctamin 1	Homo sapiens	7-14	
31683182-1	2019	Recently there has been a flurry of interest in the regulation of the homo-dimeric calcium-activated chloride channel ANO1 (also known as TMEM16A) by phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2).	Phosphatidylinositol 4,5-Diphosphate	150-189	anoctamin 1	Homo sapiens	118-122	
31683182-1	2019	Recently there has been a flurry of interest in the regulation of the homo-dimeric calcium-activated chloride channel ANO1 (also known as TMEM16A) by phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2).	Phosphatidylinositol 4,5-Diphosphate	150-189	anoctamin 1	Homo sapiens	138-145	
31515451-0	2019	A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl- channel ANO1 (TMEM16A).	Phosphatidylinositol 4,5-Diphosphate	13-50	anoctamin 1	Homo sapiens	89-115	
31515451-0	2019	A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl- channel ANO1 (TMEM16A).	Phosphatidylinositol 4,5-Diphosphate	13-50	anoctamin 1	Homo sapiens	116-120	
31515451-0	2019	A network of phosphatidylinositol 4,5-bisphosphate binding sites regulates gating of the Ca2+-activated Cl- channel ANO1 (TMEM16A).	Phosphatidylinositol 4,5-Diphosphate	13-50	anoctamin 1	Homo sapiens	122-129	
31515451-2	2019	ANO1 is activated by elevation of cytosolic Ca2+ and modulated by phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2].	Phosphatidylinositol 4,5-Diphosphate	66-103	anoctamin 1	Homo sapiens	0-4	
31434906-0	2019	Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A.	Phosphatidylinositol 4,5-Diphosphate	19-23	anoctamin 1	Homo sapiens	84-91	
31434906-3	2019	Here we show that phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates TMEM16A channel activation and desensitization via binding to a putative binding site at the cytosolic interface of transmembrane segments (TMs) 3-5.	Phosphatidylinositol 4,5-Diphosphate	18-57	anoctamin 1	Homo sapiens	75-82	
31434906-3	2019	Here we show that phosphatidylinositol (4,5)-bisphosphate (PIP2) regulates TMEM16A channel activation and desensitization via binding to a putative binding site at the cytosolic interface of transmembrane segments (TMs) 3-5.	Phosphatidylinositol 4,5-Diphosphate	59-63	anoctamin 1	Homo sapiens	75-82	
31434906-4	2019	We further demonstrate that the ion-conducting pore of TMEM16A is constituted of two functionally distinct modules: a Ca2+-binding module formed by TMs 6-8 and a PIP2-binding regulatory module formed by TMs 3-5, which mediate channel activation and desensitization, respectively.	Phosphatidylinositol 4,5-Diphosphate	162-166	anoctamin 1	Homo sapiens	55-62	
29229864-6	2017	We demonstrate that TMEM16A-mediated control of cytoplasmic Cl- regulates the organization of the major phosphoinositide species PtdIns(4,5)P2 into microdomains on the plasma membrane, analogous to processes that cluster soluble and membrane proteins into phase-separated droplets.	Phosphatidylinositol 4,5-Diphosphate	129-142	anoctamin 1	Homo sapiens	20-27	
29229864-8	2017	Our study thus uncovers a critical function of CaCC-mediated cytoplasmic Cl- homeostasis in controlling the organization of PtdIns(4,5)P2 microdomains and membrane remodeling.	Phosphatidylinositol 4,5-Diphosphate	124-137	anoctamin 1	Homo sapiens	47-51