PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20472831-4	2010	In addition, we carried out coimmunoprecipitation analyses and also used a pharmacologic reagent to reduce the level of phosphatidylinositol-4,5-bisphosphate (PIP(2)).	Phosphatidylinositol 4,5-Diphosphate	120-157	prolactin induced protein	Homo sapiens	159-162	
19509404-1	2009	Phosphatidylinositol 3-kinase (PI3K) enzymes phosphorylate phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P(2), also known as PIP(2)], a minor but critically important phospholipid of the inner leaflet of the plasma membrane.	Phosphatidylinositol 4,5-Diphosphate	59-96	prolactin induced protein	Homo sapiens	129-132	
20338845-1	2010	Phosphoinositides like phosphatidylinositol 4,5-bisphosphate (PIP(2)) are negatively charged lipids that play a pivotal role in membrane trafficking, signal transduction, and protein anchoring.	Phosphatidylinositol 4,5-Diphosphate	23-60	prolactin induced protein	Homo sapiens	62-65	
20472984-1	2010	Tamoxifen inhibits transmembrane currents of the Kir2.x inward rectifier potassium channels by interfering with the interaction of the channels with membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)).	Phosphatidylinositol 4,5-Diphosphate	158-195	prolactin induced protein	Homo sapiens	197-200	
19729450-3	2009	Here, we show that in cultured beta-cells, cholesterol acts through phosphatidylinositol 4,5-bisphosphate (PIP(2)) to regulate actin dynamics, plasma membrane potential, and glucose-stimulated insulin secretion.	Phosphatidylinositol 4,5-Diphosphate	68-105	prolactin induced protein	Homo sapiens	107-110	
20670831-2	2010	We show that high-voltage activated Ca(2+) channels are regulated by membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) with different sensitivities.	Phosphatidylinositol 4,5-Diphosphate	78-115	prolactin induced protein	Homo sapiens	117-120	
19948740-1	2010	Toll-like receptor 4 (TLR4) is unique among the Toll-like receptors in its ability to utilize TLR/IL1R-domain-containing adaptor protein (TIRAP), which recruits TLR4-MyD88 to phosphatidylinositol 4,5-bisphosphate (PIP(2))-rich sites on the plasma membrane, to activate NF-kappaB and MAPK pathways.	Phosphatidylinositol 4,5-Diphosphate	175-212	prolactin induced protein	Homo sapiens	214-217	
19934648-3	2010	IKs has been shown to be regulated by both beta-adrenergic receptors, via protein kinase A (PKA), and by Gq protein coupled receptors (GqPCR), via protein kinase C (PKC) and phosphatidylinositol 4,5-bisphosphate (PIP(2)).	Phosphatidylinositol 4,5-Diphosphate	174-211	prolactin induced protein	Homo sapiens	213-216	
19808673-1	2009	We have previously reported that the epithelial cell-specific actin-binding protein villin directly associates with phosphatidylinositol 4,5-bisphosphate (PIP(2)) through three binding sites that overlap with actin-binding sites in villin.	Phosphatidylinositol 4,5-Diphosphate	116-153	prolactin induced protein	Homo sapiens	155-158	
19639958-2	2009	We present here the preparation of a multivalent analogue of a phosphatidylinositol-4,5-bisphosphate (PIP(2)) micelle containing only the polar headgroup portion of this lipid.	Phosphatidylinositol 4,5-Diphosphate	63-100	prolactin induced protein	Homo sapiens	102-105	
18923421-2	2008	Formin-binding protein 17 (FBP17) and Toca-1 contain EFC/F-BAR domains and bind to neural Wiskott-Aldrich syndrome protein (N-WASP), which links phosphatidylinositol (4,5)-bisphosphate (PIP(2)) and the Rho family GTPase Cdc42 to the Arp2/3 complex.	Phosphatidylinositol 4,5-Diphosphate	145-184	prolactin induced protein	Homo sapiens	186-189	
19332618-2	2009	M(1) muscarinic receptor (M(1)R) activation couples through Galpha(q) to stimulate phospholipase C (PLC), which cleaves phosphatidylinositol 4,5-bisphosphate (PIP(2)).	Phosphatidylinositol 4,5-Diphosphate	120-157	prolactin induced protein	Homo sapiens	159-162	
19036880-1	2009	We recently found that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2))-regulated filamentous actin (F-actin) polymerization was diminished in hyperinsulinemic cell culture models of insulin resistance.	Phosphatidylinositol 4,5-Diphosphate	39-76	prolactin induced protein	Homo sapiens	78-81	
19172411-2	2009	The disorder is due to the deficiency of the phosphatidylinositol 4,5-bisphosphate (PIP(2)) 5-phosphatase, ocrl1.	Phosphatidylinositol 4,5-Diphosphate	45-82	prolactin induced protein	Homo sapiens	84-87	
19956793-0	2008	Spatial Segregation of Phosphatidylinositol 4,5-Bisphosphate (PIP(2)) Signaling in Immune Cell Functions.	Phosphatidylinositol 4,5-Diphosphate	23-60	prolactin induced protein	Homo sapiens	62-65	
19956793-1	2008	Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is a prevalent phosphoinositide in the inner leaflet of the plasma membrane.	Phosphatidylinositol 4,5-Diphosphate	0-37	prolactin induced protein	Homo sapiens	39-42	
18572937-3	2008	Of particular interest in this context are the polyphosphoinositides (PPI"s), especially phosphatidylinositol (4,5) bisphosphate (PIP 2).	Phosphatidylinositol 4,5-Diphosphate	89-128	prolactin induced protein	Homo sapiens	130-133	
18610985-2	2008	Upon activation by cytoplasmic Ca (2+) ions, the C2 domain specifically binds to the plasma membrane inner leaflet where it recognizes the target lipids phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP 2).	Phosphatidylinositol 4,5-Diphosphate	181-218	prolactin induced protein	Homo sapiens	220-223	
18758068-5	2008	Intracellularly-applied phosphatidylinositol 4,5-bisphosphate (PIP(2)) slowed the rate of desensitization.	Phosphatidylinositol 4,5-Diphosphate	24-61	prolactin induced protein	Homo sapiens	63-66	
18341295-1	2008	The mechanism of interaction of pleckstrin homology (PH) domains with phosphatidylinositol 4,5-bisphosphate (PIP 2)-containing lipid bilayers remains uncertain.	Phosphatidylinositol 4,5-Diphosphate	70-107	prolactin induced protein	Homo sapiens	109-112	
18562499-2	2008	BK channels are thought to be regulated by phosphatidylinositol 4,5-bisphosphate (PIP(2)) only through phospholipase C (PLC)-generated PIP(2) metabolites that target Ca(2+) stores and protein kinase C and, eventually, the BK channel.	Phosphatidylinositol 4,5-Diphosphate	43-80	prolactin induced protein	Homo sapiens	82-85	
17182619-2	2007	Here, we have identified a conserved set of basic residues on the surface of CP that are important for the interaction with phosphatidylinositol 4,5-bisphosphate (PIP(2)).	Phosphatidylinositol 4,5-Diphosphate	124-161	prolactin induced protein	Homo sapiens	163-166	
17588168-1	2007	Phosphoinositides in general and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2) or PIP(2)) in particular have been recently found to function as important regulators of ion channels.	Phosphatidylinositol 4,5-Diphosphate	33-70	prolactin induced protein	Homo sapiens	87-90	
17395626-4	2007	The channels require membrane phosphatidylinositol-4,5-bisphosphate (PIP(2)) to open and the effects of mAChR stimulation result primarily from the reduction in membrane PIP(2) levels following G(q)/phospholipase C-catalysed PIP(2) hydrolysis.	Phosphatidylinositol 4,5-Diphosphate	30-67	prolactin induced protein	Homo sapiens	69-72	
17395626-4	2007	The channels require membrane phosphatidylinositol-4,5-bisphosphate (PIP(2)) to open and the effects of mAChR stimulation result primarily from the reduction in membrane PIP(2) levels following G(q)/phospholipase C-catalysed PIP(2) hydrolysis.	Phosphatidylinositol 4,5-Diphosphate	30-67	prolactin induced protein	Homo sapiens	170-173	
17395626-4	2007	The channels require membrane phosphatidylinositol-4,5-bisphosphate (PIP(2)) to open and the effects of mAChR stimulation result primarily from the reduction in membrane PIP(2) levels following G(q)/phospholipase C-catalysed PIP(2) hydrolysis.	Phosphatidylinositol 4,5-Diphosphate	30-67	prolactin induced protein	Homo sapiens	170-173	
17412762-1	2007	Phosphatidylinositol 4,5-bisphosphate (PIP(2))-mediated signalling is a new and rapidly developing area in the field of cellular signal transduction.	Phosphatidylinositol 4,5-Diphosphate	0-37	prolactin induced protein	Homo sapiens	39-42	
17031667-2	2007	Recently, several members of the TRP channel family were reported to be regulated by phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2), PIP(2)).	Phosphatidylinositol 4,5-Diphosphate	85-122	prolactin induced protein	Homo sapiens	141-144	
17520274-1	2007	Phosphatidylinositol (4,5)-bisphosphate (PIP(2)) is an important lipid mediator that has multiple regulatory functions.	Phosphatidylinositol 4,5-Diphosphate	0-39	prolactin induced protein	Homo sapiens	41-44	
17724161-1	2007	Activity of KCNQ (Kv7) channels requires binding of phosphatidylinositol 4,5-bisphosphate (PIP(2)) from the plasma membrane.	Phosphatidylinositol 4,5-Diphosphate	52-89	prolactin induced protein	Homo sapiens	91-94	
15857907-1	2005	G protein-gated inward rectifier (Kir3) channels are inhibited by activation of G(q/11)-coupled receptors and this has been postulated to involve the signaling molecules protein kinase C (PKC) and/or phosphatidylinositol 4,5-bisphosphate (PIP(2)).	Phosphatidylinositol 4,5-Diphosphate	200-237	prolactin induced protein	Homo sapiens	239-242	
17233611-1	2007	The TRPC (transient receptor potential canonical) proteins are activated in response to agonist-stimulated PIP(2) (phosphatidylinositol 4,5-bisphosphate) hydrolysis and have been suggested as candidate components of the elusive SOC (store-operated calcium channel).	Phosphatidylinositol 4,5-Diphosphate	115-152	prolactin induced protein	Homo sapiens	107-110	
17074062-2	2007	Both thermosensitive cation channels are critically regulated by the membrane lipid, phosphatidylinositol 4,5-bisphosphate (PIP(2)).	Phosphatidylinositol 4,5-Diphosphate	85-122	prolactin induced protein	Homo sapiens	124-127	
15664188-1	2005	Phosphatidylinositol 4,5-bisphosphate (PIP(2)) activates the actin regulatory protein N-WASP by binding to a short polybasic region involved in N-WASP autoinhibition.	Phosphatidylinositol 4,5-Diphosphate	0-37	prolactin induced protein	Homo sapiens	39-42	
15627218-2	2005	Lowe syndrome, a multisystem disease characterized by renal tubulopathy, congenital cataracts, and mental retardation, is associated with mutations in the gene OCRL1, which encodes a phosphatidylinositol 4,5-bisphosphate (PIP(2)) 5-phosphatase.	Phosphatidylinositol 4,5-Diphosphate	183-220	prolactin induced protein	Homo sapiens	222-225	
14710196-4	2004	Here, we report that phosphatidylinositol 4,5-bisphosphate (PIP(2)) activates human CFTR, resulting in ATP responsiveness of PIP(2)-treated CFTR.	Phosphatidylinositol 4,5-Diphosphate	21-58	prolactin induced protein	Homo sapiens	60-63	
15464023-1	2004	The membrane phospholipid, phosphatidylinositol 4,5-bisphosphate (PIP(2)), plays a critical role in various, apparently very different cellular processes.	Phosphatidylinositol 4,5-Diphosphate	27-64	prolactin induced protein	Homo sapiens	66-69	
15024008-3	2004	Here, we demonstrate that neomycin, a drug that masks the cellular substrate of PI3K, phosphatidylinositol 4,5-bisphosphate (PIP), prevents wortmannin inhibition of insulin-stimulated (2)Glut4 translocation and glucose transport without activating protein kinase B, a downstream effector of PI3K.	Phosphatidylinositol 4,5-Diphosphate	86-123	prolactin induced protein	Homo sapiens	125-128	
14594952-2	2004	Previous studies report that phosphatidylinositol 4,5-bisphosphate (PIP(2)) regulates actin severing by villin, presumably by interaction with villin.	Phosphatidylinositol 4,5-Diphosphate	29-66	prolactin induced protein	Homo sapiens	68-71	
14710196-4	2004	Here, we report that phosphatidylinositol 4,5-bisphosphate (PIP(2)) activates human CFTR, resulting in ATP responsiveness of PIP(2)-treated CFTR.	Phosphatidylinositol 4,5-Diphosphate	21-58	prolactin induced protein	Homo sapiens	125-128	
12782119-1	2003	A mathematical account is given of the processes governing the time courses of calcium ions (Ca2+), inositol 1,4,5-trisphosphate (IP(3)) and phosphatidylinositol 4,5-bisphosphate (PIP(2)) in single cells following the application of external agonist to metabotropic receptors.	Phosphatidylinositol 4,5-Diphosphate	141-178	prolactin induced protein	Homo sapiens	180-183	
14532114-1	2003	Phosphatidylinositol-4,5-bisphosphate (PIP(2)) is a major signaling molecule implicated in the regulation of various ion transporters and channels.	Phosphatidylinositol 4,5-Diphosphate	0-37	prolactin induced protein	Homo sapiens	39-42	
12086641-2	2002	The activity of Kir channels is critically dependent on the integrity of channel interactions with phosphatidylinositol 4,5-bisphosphate (PIP(2)).	Phosphatidylinositol 4,5-Diphosphate	99-136	prolactin induced protein	Homo sapiens	138-141	
12799190-5	2003	Nuclear DGK-theta co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)) in domains that correspond to nuclear speckles, as revealed by the use of an antibody to the splicing factor SC-35, a well-established marker for these structures.	Phosphatidylinositol 4,5-Diphosphate	36-73	prolactin induced protein	Homo sapiens	75-78	
12221130-1	2002	Phosphatidylinositol 4, 5-bisphosphate (PIP(2)) at the inner leaflet of the plasma membrane has been proposed to locally regulate the actin cytoskeleton.	Phosphatidylinositol 4,5-Diphosphate	0-38	prolactin induced protein	Homo sapiens	40-43	
12153242-2	2002	The title compound, Pea-PIP(2), possesses a phosphatidylethanolamine (PE) headgroup at the 1-position and a phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) headgroup at the 4-position.	Phosphatidylinositol 4,5-Diphosphate	108-145	prolactin induced protein	Homo sapiens	24-27	
11812779-1	2002	Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is a membrane lipid found in all eukaryotic cells, which regulates many important cellular processes, including ion channel activity.	Phosphatidylinositol 4,5-Diphosphate	0-37	prolactin induced protein	Homo sapiens	39-42	
11941371-4	2002	Numerous experimental approaches demonstrated that phosphatidylinositol 4,5-bisphosphate (PIP(2)), the substrate of PLC, is a key regulator of TRPM7.	Phosphatidylinositol 4,5-Diphosphate	51-88	prolactin induced protein	Homo sapiens	90-93	
10962106-1	2000	Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is an essential cofactor of phospholipase D (PLD) enzymes.	Phosphatidylinositol 4,5-Diphosphate	0-37	prolactin induced protein	Homo sapiens	39-42	
11306691-1	2001	Recent work has established membrane phospholipids such as phosphatidylinositol-4,5-bisphosphate (PIP(2)) as potent regulators of K(ATP) channels controlling open probability and ATP sensitivity.	Phosphatidylinositol 4,5-Diphosphate	59-96	prolactin induced protein	Homo sapiens	98-101	
11055989-1	2000	Phosphatidylinositol 4,5-bisphosphate (PIP(2)) activates K(ATP) and other inward rectifier (Kir) channels.	Phosphatidylinositol 4,5-Diphosphate	0-37	prolactin induced protein	Homo sapiens	39-42	
10972934-3	2000	One of the interesting features of this pathway is that the substrate of PLC, the lipid phosphatidylinositol (4,5)-bisphosphate (PIP(2)), is turned over quite rapidly and must be constantly resupplied to the plasma membrane by a known transfer mechanism.	Phosphatidylinositol 4,5-Diphosphate	88-127	prolactin induced protein	Homo sapiens	129-132	
10801334-3	2000	We reported previously that phosphatidylinositol 4,5-bisphosphate (PIP(2)) is a positive regulator of Ca(2+)-induced scrambling.	Phosphatidylinositol 4,5-Diphosphate	28-65	prolactin induced protein	Homo sapiens	67-70	
10893269-4	2000	Depletion of ATP was accompanied by a marked reduction of plasmalemmal phosphatidylinositol 4,5-bisphosphate (PIP(2)) content.	Phosphatidylinositol 4,5-Diphosphate	71-108	prolactin induced protein	Homo sapiens	110-113	
10556088-6	1999	Together with the previous finding that the PI4P5K product phosphatidylinositol 4,5-bisphosphate (PIP(2)) activates ERM proteins in vitro [16], our data suggest that PIP(2), and not ROCK kinases, is involved in the RhoA-dependent activation of ERM proteins in vivo.	Phosphatidylinositol 4,5-Diphosphate	59-96	prolactin induced protein	Homo sapiens	98-101	
10801429-1	2000	A recent application of optical tweezers has shown that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) levels control adhesion of the membrane bilayer to the underlying cytoskeleton, by regulated direct binding of PIP(2) to cytoskeletal proteins and/or indirect effects on cytoskeleton structure.	Phosphatidylinositol 4,5-Diphosphate	72-109	prolactin induced protein	Homo sapiens	111-114	
10801429-1	2000	A recent application of optical tweezers has shown that plasma membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)) levels control adhesion of the membrane bilayer to the underlying cytoskeleton, by regulated direct binding of PIP(2) to cytoskeletal proteins and/or indirect effects on cytoskeleton structure.	Phosphatidylinositol 4,5-Diphosphate	72-109	prolactin induced protein	Homo sapiens	230-233	
10751430-1	2000	Mammalian rod cyclic nucleotide gated (CNG) channels (i.e., alpha plus beta subunits) are strongly inhibited by phosphatidylinositol 4, 5-bisphosphate (PIP(2)) when they are expressed in Xenopus oocytes and studied in giant membrane patches.	Phosphatidylinositol 4,5-Diphosphate	112-150	prolactin induced protein	Homo sapiens	152-155	
10556088-6	1999	Together with the previous finding that the PI4P5K product phosphatidylinositol 4,5-bisphosphate (PIP(2)) activates ERM proteins in vitro [16], our data suggest that PIP(2), and not ROCK kinases, is involved in the RhoA-dependent activation of ERM proteins in vivo.	Phosphatidylinositol 4,5-Diphosphate	59-96	prolactin induced protein	Homo sapiens	166-169	
22891352-3	2012	Although the phospholipid phosphatidylinositol-4,5-bisphosphate (PIP(2)) in the inner membrane leaflet has emerged as a universal activator of ion channels, no such role has been established for mammalian Kv channels.	Phosphatidylinositol 4,5-Diphosphate	26-63	prolactin induced protein	Homo sapiens	65-68	
10435998-3	1999	Phosphatidylinositol 4, 5-bisphosphate (PIP(2)) profoundly antagonized ATP inhibition of K(ATP) channels expressed from cloned Kir6.2+SUR1 subunits, but also abolished high affinity tolbutamide sensitivity.	Phosphatidylinositol 4,5-Diphosphate	0-38	prolactin induced protein	Homo sapiens	40-43	
2159335-1	1990	A method is reported for the synthesis of pyrene-labeled analogues of phosphatidylinositol 4-phosphate (Pyr-PIP) and phosphatidylinositol 4,5-biphosphate (Pyr-PIP2) from sn-2-(pyrenyl-decanoyl)phosphatidylinositol (Pyr-PI) using partially purified PI and PIP kinase preparations.	Phosphatidylinositol 4,5-Diphosphate	117-153	prolactin induced protein	Homo sapiens	159-162	
10508590-2	1999	Members of one of these families, the type II phosphatidylinositol phosphate kinases (PIP kinases), are 4-kinases and are thought to catalyse a minor route of synthesis of the multifunctional phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)) from the inositide PI(5)P [2].	Phosphatidylinositol 4,5-Diphosphate	192-229	prolactin induced protein	Homo sapiens	86-89	
10358924-2	1999	The last step of PtdIns(4,5)P2 synthesis is catalyzed by PtdIns monophosphate(PIP) kinase.	Phosphatidylinositol 4,5-Diphosphate	17-30	prolactin induced protein	Homo sapiens	78-81	
9367159-2	1997	The enzymes that produce PtdIns-4,5-P2 in vitro fall into two related subfamilies (type I and type II PtdInsP-5-OH kinases, or PIP(5)Ks) based on their enzymatic properties and sequence similarities".	Phosphatidylinositol 4,5-Diphosphate	25-38	prolactin induced protein	Homo sapiens	127-130	
3021152-3	1986	On the other hand, 12-O-tetradecanoyl phorbol acetate(TPA) mainly inhibited the conversion of phosphatidylinositol 4-phosphate(PIP) to PIP2 without a significant effect on the fMLP-induced breakdown of PIP2, though direct effect of TPA on PI and PIP kinases was not demonstrated in isolated plasma membranes.	Phosphatidylinositol 4,5-Diphosphate	135-139	prolactin induced protein	Homo sapiens	127-130	
3021152-3	1986	On the other hand, 12-O-tetradecanoyl phorbol acetate(TPA) mainly inhibited the conversion of phosphatidylinositol 4-phosphate(PIP) to PIP2 without a significant effect on the fMLP-induced breakdown of PIP2, though direct effect of TPA on PI and PIP kinases was not demonstrated in isolated plasma membranes.	Phosphatidylinositol 4,5-Diphosphate	202-206	prolactin induced protein	Homo sapiens	127-130	
23530136-3	2013	Heteromeric cone CNGA3 (A3) + CNGB3 (B3) channels are inhibited by membrane phosphoinositides (PIP(n)), including phosphatidylinositol 3,4,5-triphosphate (PIP(3)) and phosphatidylinositol 4,5-bisphosphate (PIP(2)), demonstrating a decrease in apparent affinity for cyclic guanosine monophosphate (cGMP).	Phosphatidylinositol 4,5-Diphosphate	167-204	prolactin induced protein	Homo sapiens	95-98	
23530136-3	2013	Heteromeric cone CNGA3 (A3) + CNGB3 (B3) channels are inhibited by membrane phosphoinositides (PIP(n)), including phosphatidylinositol 3,4,5-triphosphate (PIP(3)) and phosphatidylinositol 4,5-bisphosphate (PIP(2)), demonstrating a decrease in apparent affinity for cyclic guanosine monophosphate (cGMP).	Phosphatidylinositol 4,5-Diphosphate	167-204	prolactin induced protein	Homo sapiens	155-158	
23530136-3	2013	Heteromeric cone CNGA3 (A3) + CNGB3 (B3) channels are inhibited by membrane phosphoinositides (PIP(n)), including phosphatidylinositol 3,4,5-triphosphate (PIP(3)) and phosphatidylinositol 4,5-bisphosphate (PIP(2)), demonstrating a decrease in apparent affinity for cyclic guanosine monophosphate (cGMP).	Phosphatidylinositol 4,5-Diphosphate	167-204	prolactin induced protein	Homo sapiens	155-158	
22950482-0	2012	Phosphatidylinositol 4,5-biphosphate (PIP(2)) lipids regulate the phosphorylation of syntaxin N-terminus by modulating both its position and local structure.	Phosphatidylinositol 4,5-Diphosphate	0-36	prolactin induced protein	Homo sapiens	38-41	
23055973-1	2012	Over the past 16 years, there has been an impressive number of ion channels shown to be sensitive to the major phosphoinositide in the plasma membrane, phosphatidylinositol 4,5-bisphosphate (PIP(2)).	Phosphatidylinositol 4,5-Diphosphate	152-189	prolactin induced protein	Homo sapiens	191-194	
22609963-4	2012	Furthermore, we show that calcium and diacylglycerol converge in a signaling pathway leading to the production of phosphatidylinositol 4,5-bisphosphate (PIP(2)).	Phosphatidylinositol 4,5-Diphosphate	114-151	prolactin induced protein	Homo sapiens	153-156	
22595022-5	2012	Moreover, phosphatidylinositol 4,5-bisphosphate (PIP(2) ) induced a conformational change in Preso toward the open PDZ domain and enhanced the interaction with betaPix.	Phosphatidylinositol 4,5-Diphosphate	10-47	prolactin induced protein	Homo sapiens	49-52	
22613714-3	2012	Brag2 contains a pleckstrin homology (PH) domain, and its nucleotide exchange activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP(2)).	Phosphatidylinositol 4,5-Diphosphate	104-141	prolactin induced protein	Homo sapiens	143-146	
21654216-1	2011	ATP-sensitive potassium (K(ATP)) channels are inhibited by ATP and activated by phosphatidylinositol 4,5-bisphosphate (PIP(2)).	Phosphatidylinositol 4,5-Diphosphate	80-117	prolactin induced protein	Homo sapiens	119-122	
22475207-4	2012	The objective of this work was to determine the effect of phosphatidylinositol 4,5-bisphosphate (PIP(2)) on the C2alpha-Pb(2+) interactions.	Phosphatidylinositol 4,5-Diphosphate	58-95	prolactin induced protein	Homo sapiens	97-100	
21826776-1	2011	Phosphatidylinositol 4,5-bis-phosphate (PIP(2)) is an important lipid in regulation of several cellular processes, particularly membrane fusion.	Phosphatidylinositol 4,5-Diphosphate	0-38	prolactin induced protein	Homo sapiens	40-43	
21795401-1	2011	To account for the many functions of phosphatidylinositol 4,5-bisphosphate (PIP(2)), several investigators have proposed that there are separate pools of PIP(2) in the plasma membrane.	Phosphatidylinositol 4,5-Diphosphate	37-74	prolactin induced protein	Homo sapiens	76-79	
21795401-1	2011	To account for the many functions of phosphatidylinositol 4,5-bisphosphate (PIP(2)), several investigators have proposed that there are separate pools of PIP(2) in the plasma membrane.	Phosphatidylinositol 4,5-Diphosphate	37-74	prolactin induced protein	Homo sapiens	154-157	
21874019-2	2011	In particular, phosphatidylinositol 4,5-bisphosphate (PIP(2)), a minor yet dynamic phospholipid component of cell membranes, is known to regulate many different ion channels.	Phosphatidylinositol 4,5-Diphosphate	15-52	prolactin induced protein	Homo sapiens	54-57	
21876211-3	2012	In our current study, we show that the reduction in phosphoinositide [PtdInsP (also known as PIP) and PtdInsP(2) (also known as PIP(2))] production caused by VPA is acute and dose dependent, and that this effect occurs independently of phosphatidylinositol 3-kinase (PI3K) activity, inositol recycling and inositol synthesis.	Phosphatidylinositol 4,5-Diphosphate	70-77	prolactin induced protein	Homo sapiens	93-96	
21876211-3	2012	In our current study, we show that the reduction in phosphoinositide [PtdInsP (also known as PIP) and PtdInsP(2) (also known as PIP(2))] production caused by VPA is acute and dose dependent, and that this effect occurs independently of phosphatidylinositol 3-kinase (PI3K) activity, inositol recycling and inositol synthesis.	Phosphatidylinositol 4,5-Diphosphate	102-112	prolactin induced protein	Homo sapiens	128-131	
22403073-1	2012	Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is a membrane bound lipid molecule with capabilities to affect a wide array of signaling pathways to regulate very different cellular processes.	Phosphatidylinositol 4,5-Diphosphate	0-37	prolactin induced protein	Homo sapiens	39-42	
21576493-1	2011	Phosphatidylinositol 4,5-bisphosphate (PIP(2)) is necessary for the function of various ion channels.	Phosphatidylinositol 4,5-Diphosphate	0-37	prolactin induced protein	Homo sapiens	39-42	
21158426-1	2011	Phospholipase C isozymes (PLCs) catalyze the conversion of the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) into two second messengers, inositol 1,4,5-trisphosphate and diacylglycerol.	Phosphatidylinositol 4,5-Diphosphate	78-115	prolactin induced protein	Homo sapiens	117-120	
21281576-3	2011	Our results demonstrate that Kir2.1 and Kir2.2 have two distinct lipid requirements for activity: a specific requirement for phosphatidylinositol 4,5-bisphosphate (PIP(2)) and a nonspecific requirement for anionic phospholipids.	Phosphatidylinositol 4,5-Diphosphate	125-162	prolactin induced protein	Homo sapiens	164-167	
21107857-1	2011	Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P(2) or PIP(2)] is a direct modulator of a diverse array of proteins in eukaryotic cells.	Phosphatidylinositol 4,5-Diphosphate	0-37	prolactin induced protein	Homo sapiens	54-57	
21051544-1	2011	Phosphatidylinositol 4,5-bisphosphate (PIP(2)) regulates Ca(2+) (I(Ca)) and M-type K(+) currents in superior cervical ganglion sympathetic neurons.	Phosphatidylinositol 4,5-Diphosphate	0-37	prolactin induced protein	Homo sapiens	39-42	
21156029-2	2011	Emerging evidence suggests that BASP1 is critically involved in various cellular processes, in particular, in the accumulation of phosphatidylinositol-4,5-diphosphate (PIP(2)) in lipid raft microdomains.	Phosphatidylinositol 4,5-Diphosphate	130-166	prolactin induced protein	Homo sapiens	168-171	
21097841-7	2011	Insulin treatment promoted an increase in levels of the signaling phospholipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) in plasmalemmal caveolae.	Phosphatidylinositol 4,5-Diphosphate	79-116	prolactin induced protein	Homo sapiens	118-121	
21219032-3	2010	The authors have demonstrated the formation and characterized the assembly kinetics of SLBs incorporating phosphatidylinositol 4,5-biphosphate (PIP(2); 1, 5, and 10 wt %) and phosphoinositol-3,4,5-triphosphate (1 wt %) using the quartz crystal microbalance with dissipation monitoring and fluorescence recovery after photobleaching.	Phosphatidylinositol 4,5-Diphosphate	106-142	prolactin induced protein	Homo sapiens	144-147	
20729206-4	2010	Concurrently, activated m-calpain is localized to its inner membrane milieu by binding to phosphatidylinositol 4,5-bisphosphate (PIP(2)).	Phosphatidylinositol 4,5-Diphosphate	90-127	prolactin induced protein	Homo sapiens	129-132