PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20552043-7	2010	We and others have shown that the expression and activity of beta-secretase (named BACE1; beta-site APP cleaving enzyme) is increased by oxidant agents and by lipid peroxidation product 4-hydroxynonenal and that there is a significant correlation between BACE1 activity and oxidative markers in sporadic AD.	4-hydroxy-2-nonenal	186-202	beta-secretase 1	Homo sapiens	83-88	
20552043-7	2010	We and others have shown that the expression and activity of beta-secretase (named BACE1; beta-site APP cleaving enzyme) is increased by oxidant agents and by lipid peroxidation product 4-hydroxynonenal and that there is a significant correlation between BACE1 activity and oxidative markers in sporadic AD.	4-hydroxy-2-nonenal	186-202	beta-secretase 1	Homo sapiens	90-119	
20552043-7	2010	We and others have shown that the expression and activity of beta-secretase (named BACE1; beta-site APP cleaving enzyme) is increased by oxidant agents and by lipid peroxidation product 4-hydroxynonenal and that there is a significant correlation between BACE1 activity and oxidative markers in sporadic AD.	4-hydroxy-2-nonenal	186-202	beta-secretase 1	Homo sapiens	255-260	
20026385-3	2010	The lipid peroxidation product 4-Hydroxynonenal (HNE)-induced transcription of beta-secretase (BACE1) was blocked by selenium.	4-hydroxy-2-nonenal	31-47	beta-secretase 1	Homo sapiens	95-100	
20026385-3	2010	The lipid peroxidation product 4-Hydroxynonenal (HNE)-induced transcription of beta-secretase (BACE1) was blocked by selenium.	4-hydroxy-2-nonenal	49-52	beta-secretase 1	Homo sapiens	95-100	
16769154-4	2007	BACE1 activity and the amount of oxidative products were significantly correlated in all cases.Moreover, both BACE1 activity and the level of 4-hydroxynonenal were correlated with the amount of Beta-amyloid pyroglutamated 3-42, the more toxic Beta-amyloid peptide that is characteristic of AD.	4-hydroxy-2-nonenal	142-158	beta-secretase 1	Homo sapiens	0-5	
15659232-0	2005	Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.	4-hydroxy-2-nonenal	55-71	beta-secretase 1	Homo sapiens	0-29	
15659232-1	2005	4-Hydroxynonenal (HNE), an aldehydic product of lipid peroxidation, up-regulates expression of the beta-site APP cleaving enzyme (BACE-1), an aspartyl protease responsible for the beta-secretase cleavage of amyloid precursor protein (AbetaPP), and results in increased levels of amyloid beta (Abeta) peptide.	4-hydroxy-2-nonenal	0-16	beta-secretase 1	Homo sapiens	99-128	
15659232-1	2005	4-Hydroxynonenal (HNE), an aldehydic product of lipid peroxidation, up-regulates expression of the beta-site APP cleaving enzyme (BACE-1), an aspartyl protease responsible for the beta-secretase cleavage of amyloid precursor protein (AbetaPP), and results in increased levels of amyloid beta (Abeta) peptide.	4-hydroxy-2-nonenal	0-16	beta-secretase 1	Homo sapiens	130-136	
15659232-1	2005	4-Hydroxynonenal (HNE), an aldehydic product of lipid peroxidation, up-regulates expression of the beta-site APP cleaving enzyme (BACE-1), an aspartyl protease responsible for the beta-secretase cleavage of amyloid precursor protein (AbetaPP), and results in increased levels of amyloid beta (Abeta) peptide.	4-hydroxy-2-nonenal	18-21	beta-secretase 1	Homo sapiens	99-128	
15659232-1	2005	4-Hydroxynonenal (HNE), an aldehydic product of lipid peroxidation, up-regulates expression of the beta-site APP cleaving enzyme (BACE-1), an aspartyl protease responsible for the beta-secretase cleavage of amyloid precursor protein (AbetaPP), and results in increased levels of amyloid beta (Abeta) peptide.	4-hydroxy-2-nonenal	18-21	beta-secretase 1	Homo sapiens	130-136	
12270690-2	2002	In the present paper we showed that BACE is modulated by the oxidative stress product 4-hydroxynonenal (HNE).	4-hydroxy-2-nonenal	86-102	beta-secretase 1	Homo sapiens	36-40	
12270690-2	2002	In the present paper we showed that BACE is modulated by the oxidative stress product 4-hydroxynonenal (HNE).	4-hydroxy-2-nonenal	104-107	beta-secretase 1	Homo sapiens	36-40