PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15701814-16	2005	We conclude that hydroxyl radicals, either directly or indirectly, activate p38 MAPK and that p38 MAPK plays an important role in mediating cisplatin-induced acute renal injury and inflammation, perhaps through production of TNF-alpha.	Hydroxyl Radical	17-34	tumor necrosis factor	Mus musculus	225-234	
14576080-5	2004	In addition, the iron chelator 1,2-dimethyl-3-hydroxypyridin-4-one and the hydroxyl radical scavengers dimethylthiourea and dimethyl sulfoxide inhibited TNF-alpha-induced MCP-1 expression, suggesting important roles of iron and hydroxyl radicals in inflammatory signal activation.	Hydroxyl Radical	75-91	tumor necrosis factor	Mus musculus	153-162	
14576080-5	2004	In addition, the iron chelator 1,2-dimethyl-3-hydroxypyridin-4-one and the hydroxyl radical scavengers dimethylthiourea and dimethyl sulfoxide inhibited TNF-alpha-induced MCP-1 expression, suggesting important roles of iron and hydroxyl radicals in inflammatory signal activation.	Hydroxyl Radical	228-245	tumor necrosis factor	Mus musculus	153-162	
2538230-2	1989	During incubation of TNF sensitive mouse tumorigenic fibroblast L-M cells (2 X 10(7) cells) in the presence of rhTNF (100 U), hydroxyl radical production as detected by the evolution of methane gas from dimethyl sulfoxide increased gradually, at 18 h reaching 1.8 times that in the absence of rhTNF.	Hydroxyl Radical	126-142	tumor necrosis factor	Mus musculus	21-24	
7790027-4	1995	Deferoxamine (a ferric iron chelator) and dithiothreitol (a sulfhydryl reagent) both prevented DNA damage and cell killing, indicate that hydroxyl radicals generated from O2- and H2O2 produced by the mitochondria in a process catalysed by iron contributed to DNA damage and that this pathway may be involved in TNF-alpha-induced cytotoxicity.	Hydroxyl Radical	138-155	tumor necrosis factor	Mus musculus	311-320	
1322166-3	1992	Our results indicate that mitochondrial respiration chains are damaged by a hydroxyl radical at an early stage of the cell lysis after TNF treatment.	Hydroxyl Radical	76-92	tumor necrosis factor	Mus musculus	135-138	
1550349-10	1992	The antioxidants mannitol and benzoate, as well as the iron chelator deferoxamine, reduced the extent of TNF alpha-induced oxidant effects in hepatocytes, which indicates that the oxidant stress may involve hydroxyl radical generation.	Hydroxyl Radical	207-223	tumor necrosis factor	Mus musculus	105-114	
12388222-0	2003	Overexpression of tumor necrosis factor-alpha increases production of hydroxyl radical in murine myocardium.	Hydroxyl Radical	70-86	tumor necrosis factor	Mus musculus	18-45	
2845869-2	1988	During incubation of TNF sensitive mouse tumorigenic fibroblast L-M cells in the presence of rhTNF, hydroxyl radical production detected by the evolution of methane gas from dimethyl sulfoxide increased gradually, at 18 hours reached 1.8 times of that in the absence of rhTNF.	Hydroxyl Radical	100-116	tumor necrosis factor	Mus musculus	21-24