PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25140150-8	2014	Additionally, by using structure activity relationship data obtained from fourteen structurally similar benzoic acid derivatives, it was determined that the inhibition of alpha-syn fibrillation by GA is related to the number of hydroxyl moieties and their position on the phenyl ring.	Hydroxyl Radical	228-236	synuclein alpha	Homo sapiens	171-180	
16984000-3	2006	Hydrogen peroxide is catalytically converted to the aggressive hydroxyl radical in the presence of Fe(II) and Cu(I), which renders amyloidogenic proteins such as beta-amyloid and alpha-synuclein (implicated in Alzheimer"s disease (AD) and Parkinson"s disease (PD), respectively) vulnerable to self-inflicted hydroxyl radical attack.	Hydroxyl Radical	63-79	synuclein alpha	Homo sapiens	179-194	
23123341-9	2013	Through the measurements of H(2)O(2) and hydroxyl radicals (OH) in solutions containing different forms of Cu (II) (free and complexed by unstructured or alpha-helical alpha-syn), we demonstrate that the significantly enhanced Cu (I) binding affinity helps inhibit the production of highly toxic reactive oxygen species, especially the hydroxyl radicals.	Hydroxyl Radical	336-353	synuclein alpha	Homo sapiens	168-177	
16984000-3	2006	Hydrogen peroxide is catalytically converted to the aggressive hydroxyl radical in the presence of Fe(II) and Cu(I), which renders amyloidogenic proteins such as beta-amyloid and alpha-synuclein (implicated in Alzheimer"s disease (AD) and Parkinson"s disease (PD), respectively) vulnerable to self-inflicted hydroxyl radical attack.	Hydroxyl Radical	308-324	synuclein alpha	Homo sapiens	179-194	
12661766-6	2003	These results suggest that the oligomerization of alpha-synuclein is mediated by the generation of the hydroxyl radical through the metal-catalyzed reaction.	Hydroxyl Radical	103-119	synuclein alpha	Homo sapiens	50-65	
12031892-0	2002	Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer"s disease and Parkinson"s disease.	Hydroxyl Radical	35-52	synuclein alpha	Homo sapiens	70-85	
12031892-3	2002	We have shown recently that solutions of A(beta) 1-40, A(beta) 1-42, A(beta) 25-35, alpha-synuclein and non-A(beta) component (NAC; residues 61-95 of alpha-synuclein) all liberate hydroxyl radicals upon incubation in vitro followed by the addition of small amounts of Fe(II).	Hydroxyl Radical	180-197	synuclein alpha	Homo sapiens	127-130	
12031892-5	2002	Hydroxyl radical formation was inhibited by the inclusion of catalase or metal-chelators during A(beta) or alpha-synuclein incubation.	Hydroxyl Radical	0-16	synuclein alpha	Homo sapiens	107-122	
12196137-9	2002	Toxicity induced by alpha-synuclein, NAC and NAC(1-18) oligomers occurs via an apoptotic mechanism, possibly initiated by oxidative damage, since these peptides liberate hydroxyl radicals in the presence of iron.	Hydroxyl Radical	170-187	synuclein alpha	Homo sapiens	20-35	
12196137-9	2002	Toxicity induced by alpha-synuclein, NAC and NAC(1-18) oligomers occurs via an apoptotic mechanism, possibly initiated by oxidative damage, since these peptides liberate hydroxyl radicals in the presence of iron.	Hydroxyl Radical	170-187	synuclein alpha	Homo sapiens	37-40	
12453634-5	2002	Hydroxyl radical scavengers and spin-trapping agent such as 5,5"-dimethyl 1-pyrolline N-oxide and tert-butyl-alpha-phenylnitrone significantly inhibited the aggregation of alpha-synuclein.	Hydroxyl Radical	0-16	synuclein alpha	Homo sapiens	172-187	
12453634-7	2002	This indicates that the aggregation of alpha-synuclein can be mediated by the CP/H(2)O(2) system via the generation of hydroxyl radical.	Hydroxyl Radical	119-135	synuclein alpha	Homo sapiens	39-54	
11958955-7	2002	These results suggest that the aggregation of alpha-synuclein is mediated by the Cu,Zn-SOD/H(2)O(2) system via the generation of hydroxyl radical by the free radical-generating function of the enzyme.	Hydroxyl Radical	129-145	synuclein alpha	Homo sapiens	46-61