PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29172520-1	2017	A component of the neurotoxicity of the beta amyloid peptide (Abeta) of Alzheimer"s disease is its ability to generate superoxide, hydrogen peroxide, and hydroxyl radicals by reaction of its reduced copper complex Abeta/Cu+ with molecular oxygen.	Hydroxyl Radical	154-171	amyloid beta precursor protein	Homo sapiens	40-60	
24313818-3	2013	Moreover, Cu-Abeta complexes are able to catalyze the production of hydrogen peroxide and hydroxyl radicals, and oligomeric Cu-Abeta was reported to be more reactive.	Hydroxyl Radical	90-107	amyloid beta precursor protein	Homo sapiens	13-18	
24313818-3	2013	Moreover, Cu-Abeta complexes are able to catalyze the production of hydrogen peroxide and hydroxyl radicals, and oligomeric Cu-Abeta was reported to be more reactive.	Hydroxyl Radical	90-107	amyloid beta precursor protein	Homo sapiens	127-132	
18847222-8	2008	Abeta does not silence the redox activity of Cu(2+/+) via chelation, but rather hydroxyl radicals produced as a result of Fenton-Haber Weiss reactions of ascorbate and Cu(2+) rapidly react with Abeta; thus the potentially harmful radicals are quenched.	Hydroxyl Radical	80-97	amyloid beta precursor protein	Homo sapiens	0-5	
18847222-8	2008	Abeta does not silence the redox activity of Cu(2+/+) via chelation, but rather hydroxyl radicals produced as a result of Fenton-Haber Weiss reactions of ascorbate and Cu(2+) rapidly react with Abeta; thus the potentially harmful radicals are quenched.	Hydroxyl Radical	80-97	amyloid beta precursor protein	Homo sapiens	194-199	
15036353-9	2004	We conclude that toxic Abeta peptides do indeed stimulate copper-mediated oxidation of ascorbate and generation of hydroxyl radicals.	Hydroxyl Radical	115-132	amyloid beta precursor protein	Homo sapiens	23-28	
12031892-0	2002	Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer"s disease and Parkinson"s disease.	Hydroxyl Radical	35-52	amyloid beta precursor protein	Homo sapiens	58-65	
12031892-5	2002	Hydroxyl radical formation was inhibited by the inclusion of catalase or metal-chelators during A(beta) or alpha-synuclein incubation.	Hydroxyl Radical	0-16	amyloid beta precursor protein	Homo sapiens	96-103	
12031892-6	2002	Our results suggest that hydrogen peroxide accumulates during the incubation of A(beta) or alpha-synuclein, by a metal-dependent mechanism, and that this is subsequently converted to hydroxyl radicals, on addition of Fe (II), by Fenton"s reaction.	Hydroxyl Radical	183-200	amyloid beta precursor protein	Homo sapiens	80-87	
10386999-6	1999	In the presence of Cu(II) or Fe(III), A beta produces a positive thiobarbituric-reactive substance (TBARS) assay, compatible with the generation of the hydroxyl radical (OH.).	Hydroxyl Radical	152-168	amyloid beta precursor protein	Homo sapiens	38-44	
18313326-8	2008	In the electron spin resonance study, Abeta (2 and 10 microM) markedly triggered hydroxyl radical formation in platelets.	Hydroxyl Radical	81-97	amyloid beta precursor protein	Homo sapiens	38-43	
29172520-1	2017	A component of the neurotoxicity of the beta amyloid peptide (Abeta) of Alzheimer"s disease is its ability to generate superoxide, hydrogen peroxide, and hydroxyl radicals by reaction of its reduced copper complex Abeta/Cu+ with molecular oxygen.	Hydroxyl Radical	154-171	amyloid beta precursor protein	Homo sapiens	62-67	
29172520-1	2017	A component of the neurotoxicity of the beta amyloid peptide (Abeta) of Alzheimer"s disease is its ability to generate superoxide, hydrogen peroxide, and hydroxyl radicals by reaction of its reduced copper complex Abeta/Cu+ with molecular oxygen.	Hydroxyl Radical	154-171	amyloid beta precursor protein	Homo sapiens	214-219	
26247837-5	2015	Under oxidative and nitrative stress conditions, the Abeta-Cu(II) complex caused oxidation and nitration of the Abeta Tyr 10 residue through peroxidase-like reactions, where the formation of Cu(I) and hydroxyl radical (OH) was proposed as a chemical mechanism.	Hydroxyl Radical	201-217	amyloid beta precursor protein	Homo sapiens	53-58