PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11307817-6 2001 A series of overlapping gamma" peptides was prepared for evaluation of their inhibition of 125I-labeled PPACK-thrombin binding to fibrin. Iodine-125 91-95 coagulation factor II, thrombin Homo sapiens 110-118 7503720-3 1995 Using the binding on glomerular epithelial cells of 125I-labeled ATAP2, a monoclonal antibody raised against the functional thrombin receptor, we demonstrate here that endothelin-1 induces thrombin receptor internalization in a dose- and a time-dependent manner. Iodine-125 52-56 coagulation factor II, thrombin Homo sapiens 124-132 10605952-4 1999 Cultured human umbilical vein endothelial cells were used to determine the binding of 125I-labeled unfractionated heparin and low molecular weight heparin to untreated and to thrombin-activated cells. Iodine-125 86-90 coagulation factor II, thrombin Homo sapiens 175-183 9351403-11 1997 Finally, preembedding immunogold labeling and immunoprecipitation of 125I-surface-labeled, thrombin-activated platelets further demonstrated that alpha-actinin was expressed on the plasma membrane in the absence of any detectable expression of actin and that it could from molecular complexes with TSP-1 on activated platelets. Iodine-125 69-73 coagulation factor II, thrombin Homo sapiens 91-99 7503720-3 1995 Using the binding on glomerular epithelial cells of 125I-labeled ATAP2, a monoclonal antibody raised against the functional thrombin receptor, we demonstrate here that endothelin-1 induces thrombin receptor internalization in a dose- and a time-dependent manner. Iodine-125 52-56 coagulation factor II, thrombin Homo sapiens 189-197 1721912-3 1991 Upon incubating 125I-labeled alpha-thrombin with endothelial cell matrix (ECM), the protease formed SDS-stable complexes exclusively with PAI-1, with subsequent release of these complexes into the supernatant. Iodine-125 16-20 coagulation factor II, thrombin Homo sapiens 35-43 8571329-4 1995 In the present study we examined the duration of procoagulant activity on the surface of thrombin-degranulated platelets by two methods: a prothrombinase assay, and the binding of 125I-labeled annexin. Iodine-125 180-184 coagulation factor II, thrombin Homo sapiens 89-97 7749851-3 1995 The thrombin receptor activation peptide but not control peptide showed a similar but reduced decrease in the specific binding of 125I-labeled tcu-PA to u-PAR. Iodine-125 130-134 coagulation factor II, thrombin Homo sapiens 4-12 7749851-4 1995 Incubation of thrombin-treated cultures (10 to 12 hours) in complete medium restored 125I-labeled tcu-PA ligand binding to normal levels. Iodine-125 85-89 coagulation factor II, thrombin Homo sapiens 14-22 7749851-6 1995 Decreased thrombin-induced 125I-labeled tcu-PA binding correlated with the time-dependent decrease in surface-localized plasmin generation, as measured by the direct activation of 125I-labeled Glu-plasminogen and quantification of the 20-kD light chains of 125I-labeled plasmin. Iodine-125 27-31 coagulation factor II, thrombin Homo sapiens 10-18 7749851-6 1995 Decreased thrombin-induced 125I-labeled tcu-PA binding correlated with the time-dependent decrease in surface-localized plasmin generation, as measured by the direct activation of 125I-labeled Glu-plasminogen and quantification of the 20-kD light chains of 125I-labeled plasmin. Iodine-125 180-184 coagulation factor II, thrombin Homo sapiens 10-18 8199173-8 1994 Binding of 125I-labeled prothrombin to native chyle chylomicrons was demonstrated by gradient ultracentrifugation. Iodine-125 11-15 coagulation factor II, thrombin Homo sapiens 24-35 7843281-3 1995 Using 125I-labeled ATAP2, a monoclonal antibody against the functional thrombin receptor, we found that thrombin and thrombin receptor agonist peptide (TRAP) induce homologous internalization of thrombin receptor in a dose-dependent manner. Iodine-125 6-10 coagulation factor II, thrombin Homo sapiens 71-79 7843281-3 1995 Using 125I-labeled ATAP2, a monoclonal antibody against the functional thrombin receptor, we found that thrombin and thrombin receptor agonist peptide (TRAP) induce homologous internalization of thrombin receptor in a dose-dependent manner. Iodine-125 6-10 coagulation factor II, thrombin Homo sapiens 104-112 7843281-3 1995 Using 125I-labeled ATAP2, a monoclonal antibody against the functional thrombin receptor, we found that thrombin and thrombin receptor agonist peptide (TRAP) induce homologous internalization of thrombin receptor in a dose-dependent manner. Iodine-125 6-10 coagulation factor II, thrombin Homo sapiens 104-112 7843281-3 1995 Using 125I-labeled ATAP2, a monoclonal antibody against the functional thrombin receptor, we found that thrombin and thrombin receptor agonist peptide (TRAP) induce homologous internalization of thrombin receptor in a dose-dependent manner. Iodine-125 6-10 coagulation factor II, thrombin Homo sapiens 104-112 8092274-4 1994 In addition, 8-azido-ATP and ATP inhibited binding of 125I-labeled fibrinogen to thrombin- and phorbol ester-activated platelets. Iodine-125 54-58 coagulation factor II, thrombin Homo sapiens 81-89 7903170-6 1993 Studies using 125I-labeled thrombin showed that the binding with thrombin was evidently reduced for her fibrinogen and the aberrant fibrinopeptide A as compared with that for the normal controls, indicating that A alpha Glu-11 may be critical for the fibrinogen-thrombin interaction. Iodine-125 14-18 coagulation factor II, thrombin Homo sapiens 27-35 7903170-6 1993 Studies using 125I-labeled thrombin showed that the binding with thrombin was evidently reduced for her fibrinogen and the aberrant fibrinopeptide A as compared with that for the normal controls, indicating that A alpha Glu-11 may be critical for the fibrinogen-thrombin interaction. Iodine-125 14-18 coagulation factor II, thrombin Homo sapiens 65-73 7903170-6 1993 Studies using 125I-labeled thrombin showed that the binding with thrombin was evidently reduced for her fibrinogen and the aberrant fibrinopeptide A as compared with that for the normal controls, indicating that A alpha Glu-11 may be critical for the fibrinogen-thrombin interaction. Iodine-125 14-18 coagulation factor II, thrombin Homo sapiens 65-73 2506937-1 1989 The binding of 125I-labeled human prothrombin to native and papain-treated tissue thromboplastin in the presence of CaCl2 or EDTA was studied. Iodine-125 15-19 coagulation factor II, thrombin Homo sapiens 34-45 2102614-2 1990 Clots were formed from citrated blood or plasma (supplemented with 125I-labeled fibrinogen) by adding thrombin and Ca(2+)-ions; lysis of the clots was achieved by the addition of tissue-type plasminogen activator before clot formation. Iodine-125 67-71 coagulation factor II, thrombin Homo sapiens 102-110 1940585-3 1991 In contrast, when platelets were stimulated with thrombin, binding increased fivefold to sixfold in a time-dependent and 125I-labeled thrombospondin concentration-dependent manner. Iodine-125 121-125 coagulation factor II, thrombin Homo sapiens 49-57 1940585-4 1991 Binding of 125I-labeled thrombospondin to thrombin-activated platelets required the presence of divalent cations, proceeded concomitantly with platelet release, and at a concentration of 1 nmol/L thrombin, reached a maximum of 2200 +/- 260 molecules of 125I-labeled thrombospondin bound per platelet. Iodine-125 11-15 coagulation factor II, thrombin Homo sapiens 42-50 1940585-4 1991 Binding of 125I-labeled thrombospondin to thrombin-activated platelets required the presence of divalent cations, proceeded concomitantly with platelet release, and at a concentration of 1 nmol/L thrombin, reached a maximum of 2200 +/- 260 molecules of 125I-labeled thrombospondin bound per platelet. Iodine-125 11-15 coagulation factor II, thrombin Homo sapiens 196-204 1940585-4 1991 Binding of 125I-labeled thrombospondin to thrombin-activated platelets required the presence of divalent cations, proceeded concomitantly with platelet release, and at a concentration of 1 nmol/L thrombin, reached a maximum of 2200 +/- 260 molecules of 125I-labeled thrombospondin bound per platelet. Iodine-125 253-257 coagulation factor II, thrombin Homo sapiens 42-50 1940585-6 1991 Using various experimental approaches, including studies with severe type I thrombasthenic platelets, we further demonstrated that the interaction of 125I-labeled thrombospondin with thrombin-stimulated platelets occurred as a fibrinogen- and fibrin-independent process, and that the glycoprotein IIb-IIIa complex did not function as a physiologic plasma membrane receptor for 125I-labeled thrombospondin. Iodine-125 150-154 coagulation factor II, thrombin Homo sapiens 183-191 1940585-6 1991 Using various experimental approaches, including studies with severe type I thrombasthenic platelets, we further demonstrated that the interaction of 125I-labeled thrombospondin with thrombin-stimulated platelets occurred as a fibrinogen- and fibrin-independent process, and that the glycoprotein IIb-IIIa complex did not function as a physiologic plasma membrane receptor for 125I-labeled thrombospondin. Iodine-125 377-381 coagulation factor II, thrombin Homo sapiens 183-191 1829631-1 1991 Binding of iodine-125-labeled thrombin to fibrin clots from two siblings with juvenile stroke was 30% of normal, and abnormally high amounts of the radioligand (not adsorbed by fibrin) were found in the supernatant. Iodine-125 11-21 coagulation factor II, thrombin Homo sapiens 30-38 1706335-5 1991 Binding of 125I-labeled GMP-140 to neutrophils and HL60 cells and the rosetting of neutrophils and HL60 cells by thrombin-activated platelets were inhibited by EDTA, excess unlabeled fluid-phase GMP-140, Fab fragments of an affinity-purified rabbit anti-GMP-140 antibody, and by the murine anti-GMP-140 monoclonal antibody, AK 4. Iodine-125 11-15 coagulation factor II, thrombin Homo sapiens 113-121 2853445-2 1988 In this paper the binding kinetics of 125I-labelled thrombin to purified polymorphonuclear leucocytes is characterized. Iodine-125 38-42 coagulation factor II, thrombin Homo sapiens 52-60 6258640-1 1981 Binding of 125I-labeled human alpha-thrombin to endothelial cells derived from bovine corneas was studied in tissue culture. Iodine-125 11-15 coagulation factor II, thrombin Homo sapiens 36-44 3258496-1 1988 The plasma clearance of 125I-labeled human heparin cofactor II and its complex with thrombin was studied in mice to determine whether a specific mechanism exists for the catabolism of the inhibitor-proteinase complex. Iodine-125 24-28 coagulation factor II, thrombin Homo sapiens 84-92 6437445-1 1984 When 125I-labeled thrombin was incubated with washed human platelets or with the supernatant solution of activated platelets, it formed a NaDodSO4-stable complex of apparent mass greater than 450 000 daltons. Iodine-125 5-9 coagulation factor II, thrombin Homo sapiens 18-26 6982084-6 1982 Large multimers of 125I-labeled purified FVIII/vWF underwent divalent cation-dependent association with platelets in the presence of thrombin, indicating that the loss of FVIII/vWF from thrombin releasates was due to reassociation with the platelet. Iodine-125 19-23 coagulation factor II, thrombin Homo sapiens 133-141 6982084-6 1982 Large multimers of 125I-labeled purified FVIII/vWF underwent divalent cation-dependent association with platelets in the presence of thrombin, indicating that the loss of FVIII/vWF from thrombin releasates was due to reassociation with the platelet. Iodine-125 19-23 coagulation factor II, thrombin Homo sapiens 186-194 2449435-4 1988 125I-Labeled vitronectin bound specifically in a saturable manner to platelets treated with physiological concentrations of thrombin. Iodine-125 0-4 coagulation factor II, thrombin Homo sapiens 124-132 3016716-2 1986 The concentration of each peptide that inhibits 50% of 125I-labeled fibrinogen binding to thrombin-stimulated platelets (IC50) was then determined. Iodine-125 55-59 coagulation factor II, thrombin Homo sapiens 90-98 6648893-2 1983 The interaction was monitored through the use of 125I-labelled fibrinogen, which measures both thrombin activity generated by cell-plasma interaction and fibrin/fibrinogen binding to platelets and tumor cells. Iodine-125 49-53 coagulation factor II, thrombin Homo sapiens 95-103 6780552-8 1981 Binding studies using pyridoxal-P-125I-thrombin showed a loss of both high and low affinity binding of thrombin to the surface of intact gel filtered platelets. Iodine-125 34-38 coagulation factor II, thrombin Homo sapiens 39-47 6780552-8 1981 Binding studies using pyridoxal-P-125I-thrombin showed a loss of both high and low affinity binding of thrombin to the surface of intact gel filtered platelets. Iodine-125 34-38 coagulation factor II, thrombin Homo sapiens 103-111 468986-10 1979 Binding of 125I-labeled thrombin to platelets was inhibited by factor D. Analysis of these data show that factor D does not alter the total number of thrombin molecules which bind to the platelet surface at saturation. Iodine-125 11-15 coagulation factor II, thrombin Homo sapiens 24-32 728459-1 1978 Binding of 125I-labeled thrombin to isolated human platelet plasma membranes was studied. Iodine-125 11-15 coagulation factor II, thrombin Homo sapiens 24-32