PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2170316-2 1990 The light cells were non-steroidogenic and bound 125I-labeled hCG with high affinity (Kd 3.0 x 10(-10) mol/L), whereas the steroidogenic heavier cells (Leydig cells) produced cyclic adenosine monophosphate (cAMP) and testosterone in response to hCG stimulation with very little hCG binding. Iodine-125 49-53 hypertrichosis 2 (generalised, congenital) Homo sapiens 62-65 1330502-2 1992 The light cells were vacuolated and bound 125I-labeled human choriogonadotropin (hCG) with high affinity but upon hCG stimulation in vitro, cAMP and testosterone production by these cells were minimal. Iodine-125 42-46 hypertrichosis 2 (generalised, congenital) Homo sapiens 81-84 2170316-5 1990 The cells in subfraction I, predominantly damaged Leydig cells, germ cells, and/or residual light cells, bind 125I-labeled hCG with high affinity (Kd 4.09 x 10(-10) mol/L) without producing cAMP and testosterone in response to hCG. Iodine-125 110-114 hypertrichosis 2 (generalised, congenital) Homo sapiens 227-230 2170316-5 1990 The cells in subfraction I, predominantly damaged Leydig cells, germ cells, and/or residual light cells, bind 125I-labeled hCG with high affinity (Kd 4.09 x 10(-10) mol/L) without producing cAMP and testosterone in response to hCG. Iodine-125 110-114 hypertrichosis 2 (generalised, congenital) Homo sapiens 123-126 3121643-1 1988 The time course for LH induction of luteinizing hormone (LH) receptors as reflected in binding of 125I-labeled hCG was investigated in hypophysectomized adult male rats. Iodine-125 98-102 hypertrichosis 2 (generalised, congenital) Homo sapiens 111-114 2833550-4 1988 Binding of 125I-labelled human chorionic gonadotrophin (hCG) to testis homogenate, however, was still less than 10% of normal. Iodine-125 11-15 hypertrichosis 2 (generalised, congenital) Homo sapiens 56-59 2155879-3 1990 Interstitial cells were prepared by collagenase digestion and used to measure 125I-labelled human chorionic gonadotrophin (hCG) binding capacity and androgen production in the presence or absence of hCG or dibutyryl cyclic AMP (dbcAMP). Iodine-125 78-82 hypertrichosis 2 (generalised, congenital) Homo sapiens 123-126 2155879-4 1990 At day 2 after EDS treatment, 125I-labelled hCG binding capacity was reduced to 10% of control values, while the production of testosterone and 5 alpha-androstane-3 alpha, 17 beta-diol (adiol) were non-detectable. Iodine-125 30-34 hypertrichosis 2 (generalised, congenital) Homo sapiens 44-47 2155879-6 1990 Between days 24 and 40 post-treatment, Leydig cell regeneration occurred, as indicated by a rise in 125I-labelled hCG binding capacity, increased androgen production and the presence of histologically identifiable Leydig cells. Iodine-125 100-104 hypertrichosis 2 (generalised, congenital) Homo sapiens 114-117 3031049-3 1987 Binding sites for 125I-labeled human chorionic gonadotropin (hCG) were preferentially localized in the light cell fraction (apparent Kd = 2.02 X 10(-10) M; Bmax = 1.17 X 10(-5) nmol/2 X 10(6) cells). Iodine-125 18-22 hypertrichosis 2 (generalised, congenital) Homo sapiens 61-64 3003355-0 1986 Study using in-vivo binding of 125I-labelled hCG, light and electron microscopy of the repopulation of rat Leydig cells after destruction due to administration of ethylene-1,2-dimethanesulphonate. Iodine-125 31-35 hypertrichosis 2 (generalised, congenital) Homo sapiens 45-48 3003355-5 1986 By 48 h the 125I-labelled hCG binding was negligible and no morphologically recognizable Leydig cells were found at this time. Iodine-125 12-16 hypertrichosis 2 (generalised, congenital) Homo sapiens 26-29 2981670-9 1985 Studies with 125I-labeled hormones further supported the conclusion that hCG differs from all other LHs in being most tightly bound and, hence, least dissociable, while eCG and rLH dissociate most readily; oLH and eLH can be placed in between these hormones in the extent of their dissociability. Iodine-125 13-17 hypertrichosis 2 (generalised, congenital) Homo sapiens 73-76 6884026-1 1983 Chemically deglycosylated preparations of hCG (DG-hCG) which have been shown to have hormonal antagonistic activity in vitro were able to compete with 125I-labeled hCG for binding sites in the ovary in pseudo-pregnant rats. Iodine-125 151-155 hypertrichosis 2 (generalised, congenital) Homo sapiens 42-45 6884026-1 1983 Chemically deglycosylated preparations of hCG (DG-hCG) which have been shown to have hormonal antagonistic activity in vitro were able to compete with 125I-labeled hCG for binding sites in the ovary in pseudo-pregnant rats. Iodine-125 151-155 hypertrichosis 2 (generalised, congenital) Homo sapiens 50-53 6884026-1 1983 Chemically deglycosylated preparations of hCG (DG-hCG) which have been shown to have hormonal antagonistic activity in vitro were able to compete with 125I-labeled hCG for binding sites in the ovary in pseudo-pregnant rats. Iodine-125 151-155 hypertrichosis 2 (generalised, congenital) Homo sapiens 50-53 217636-1 1978 Previously, we have shown that preparations of hCG bind to bovine thyroid membranes, as judged from their ability both to inhibit the binding of 125I-labeled bovine TSH (bTSH) and to activate adenylate cyclase (Amir, S.M., H. Uchimura, and S.H. Iodine-125 145-149 hypertrichosis 2 (generalised, congenital) Homo sapiens 47-50 3761277-5 1986 Autoradiography of 125I-labelled hCG binding to interstitial cell suspensions at the two ages showed that the gonadotrophin binding per Leydig cell was about 50% lower in the neonatal testis. Iodine-125 19-23 hypertrichosis 2 (generalised, congenital) Homo sapiens 33-36 6806421-2 1982 After intravenous injection of hypogonadal females with 125I-labelled human chorionic gonadotrophin (hCG), followed by autoradiography of semi-thin (1 micrometer) slices of the ovary, labelled hCG was found to be associated with interstitial cells and thecal cells with little or no labelling of granulosa cells. Iodine-125 56-60 hypertrichosis 2 (generalised, congenital) Homo sapiens 101-104 6806421-7 1982 In the male, after injection of 125-I-labelled hCG, silver grains were associated with the interstitial cells alone in both hypogonadal and normal mice. Iodine-125 32-37 hypertrichosis 2 (generalised, congenital) Homo sapiens 47-50