PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25089120-7	2014	IPE secreted IL-8 or MCP-1 in response to Pam3CSK4.3HCl, Poly(I:C), LPS and MALP-2, whereas RPE produced IL-8 only after Poly(I:C), LPS or MALP-2 treatment.	poly	57-61	C-X-C motif chemokine ligand 8	Homo sapiens	13-17	
25242873-6	2014	In response to poly (I:C), with or without ATP and/or ADP, HT-29 cells released IL-8 and this secretion was modulated by the presence of NTPDase2 and adenylate kinase.	poly	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	80-84	
16406095-7	2006	Histamine and poly (I:C), a specific TLR3 ligand stimulated interleukin (IL)-8 secretion from both cell types.	poly	14-18	C-X-C motif chemokine ligand 8	Homo sapiens	60-78	
19452017-9	2009	RESULTS: The expressions of MIP1-alpha, MIP1-beta, IL-6, IL-8, RANTES, IFN-beta, and TLR3 were up-regulated in HCECs exposed to poly(I:C).	poly	128-132	C-X-C motif chemokine ligand 8	Homo sapiens	57-61	
18048020-4	2007	CNTO2424 down-regulates poly(I:C)-induced production of IL-6, IL-8, MCP-1, RANTES, and IP-10 in human lung epithelial cells.	poly	24-28	C-X-C motif chemokine ligand 8	Homo sapiens	62-66	
23046936-7	2012	The mRNA and protein expressions of both IL-8 and IP-10  were elevated significantly by the co-stimulation of LPS and  0.1 mug/mL poly (I:C) compared with control group and simple LPS groups.	poly	130-134	C-X-C motif chemokine ligand 8	Homo sapiens	41-45	
23046936-8	2012	(2) The mRNA and protein expressions of IL-8 and IP-10 increased under the challenge of different concentrations of poly(I:C) (0.001,  0.01,  0.1 mug/mL) in a concentration-dependent manner,  which showed no change after adding 10 mug/mL LPS.	poly	116-120	C-X-C motif chemokine ligand 8	Homo sapiens	40-44	
23046936-9	2012	(3) Dexamethasone (1 mumol/L) and SB203580 (20 mumol/L) significantly decreased both the mRNA and protein production of IL-8 and IP-10 induced by co-stimulation of 0.1 mug/mL poly (I:C) and 10 mug/mL LPS compared with the control group and control+DMSO group respectively (P<0.01 and P<0.05).	poly	175-179	C-X-C motif chemokine ligand 8	Homo sapiens	120-124	
20932985-0	2011	Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-alpha via distinct NF-kappaB pathways in human nasal epithelial cells.	poly	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	63-67	
20932985-6	2011	Both the reduction of JAM-A expression and the induction of secretion of IL-8 and TNF-alpha after treatment with poly(I:C) were modulated by distinct signal transduction pathways via EGFR, PI3K, and p38 MAPK and finally regulated by a TLR3-mediated NF-kappaB pathway.	poly	113-117	C-X-C motif chemokine ligand 8	Homo sapiens	73-77	
19597128-5	2010	One hundred to 150 muM H(2)O(2) significantly potentiated the release of IL-8 from the epithelial cells after stimulation with 10 microg/ml poly(I:C).	poly	140-144	C-X-C motif chemokine ligand 8	Homo sapiens	73-77	
17669408-9	2008	Treatment of FTEC with TLR3 agonist poly(I:C) resulted in increased expression of interleukin-8, tumor-necrosis factor alpha, human beta-defensin 2, interferon beta, and interferon stimulated genes myxovirus resistance gene 1, 2",5"-oligoadenylate synthetase, and protein kinase R. Additionally, FTEC exposed to poly(I:C) also resulted in the induction of TLR2, TLR3, and TLR7.	poly	36-40	C-X-C motif chemokine ligand 8	Homo sapiens	82-124	
14688319-6	2004	Furthermore, NK cells respond to poly(I:C) by producing proinflammatory cytokines like IL-6 and IL-8, as well as the antiviral cytokine IFN-gamma.	poly	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	96-100	
15879132-3	2005	Accordingly, we observed that synthetic dsRNA, polyinosinic acid:cytidylic acid (poly(I:C)), potently induced gene remodeling in model intestinal epithelia with the specific pattern of expressed genes, including both classic proinflammatory genes (e.g., IL-8), as well as genes that are classically activated in virus-infected cells (e.g., IFN-responsive genes).	poly	47-51	C-X-C motif chemokine ligand 8	Homo sapiens	254-258	
16253565-4	2006	Incubation with poly(I:C) significantly enhanced the secretion of RANTES and IL-8.	poly	16-20	C-X-C motif chemokine ligand 8	Homo sapiens	77-81	
35114024-10	2022	In vitro exposure of HBECs to HDM furthermore reduced anti-microbial responses to Poly(I:C) including beta-defensin-2, IL-8, and TNF- , along with reduced NF-kappaB activity.	poly	82-86	C-X-C motif chemokine ligand 8	Homo sapiens	119-123	
12542924-14	2002	Addition of POLY and TAU led to comparable low IL-8 gradients with concomitant low PMN transmigration.	poly	12-16	C-X-C motif chemokine ligand 8	Homo sapiens	47-51	
26589477-7	2016	Interestingly, poly(I:C), but neither lipopolysaccharide nor R848, increased IL-8 and chemokine (C-C motif) ligand 5 secretion.	poly	15-19	C-X-C motif chemokine ligand 8	Homo sapiens	77-116	
28842514-10	2017	The poly(I:C)-induced release of inflammatory mediators, including CXCL8, interleukin (IL)-6 and CXCL1, from ASMCs from cough patients was significantly impaired compared with healthy non-cough subjects.	poly	4-8	C-X-C motif chemokine ligand 8	Homo sapiens	67-72	
26573531-5	2015	Immediately after treatment with poly(I:C), PHF11, IL8, and interferon-dependent ISG15 RNA expression was increased.	poly	33-37	C-X-C motif chemokine ligand 8	Homo sapiens	51-54	
26505478-11	2015	IL-17A promoted stabilization of CXCL8 mRNA in BEAS-2B cells treated with poly(I:C).	poly	74-78	C-X-C motif chemokine ligand 8	Homo sapiens	33-38	
26283481-6	2015	Using cell lines and primary airway epithelial cells (both submerged and well-differentiated), we observed that pure poly(I:C) stimulated IFN-beta mainly through the TLR3/TRIF pathway and IL-8 through an unidentified pathway.	poly	117-121	C-X-C motif chemokine ligand 8	Homo sapiens	188-192	
25822580-4	2015	Co-stimulation with IFN-gamma and the TLR3 ligand poly (I:C) synergistically increased the expression of IFN-beta, IL-6, IL-8, and human beta-defensin-2 in NHEKs compared with poly (I:C) or IFN-gamma alone.	poly	50-54	C-X-C motif chemokine ligand 8	Homo sapiens	121-125	
25515776-6	2015	Poly(dA:dT) induced the expression of pro-inflammatory cytokine genes including IFN-beta, TNF-alpha, IL-6 and IL-8 as well, whereas the pro-inflammatory cytokine production was suppressed by RIG-I siRNA, but not by AIM2 siRNA.	poly	0-4	C-X-C motif chemokine ligand 8	Homo sapiens	110-114