PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28684273-6 2017 In poly(dA:dT) stimulation assays, the immune molecules involved in the DDX41-mediated IFN-beta pathway in human cells were universally upregulated in chicken cells. poly 3-7 interferon beta 1 Homo sapiens 87-95 30025984-7 2018 Knockdown of duDDX41 by siRNA silencing dramatically decreased IFN-beta expression stimulated by poly(dA:dT) or duck enteritis virus (DEV). poly 97-101 interferon beta 1 Homo sapiens 63-71 27705941-3 2016 Overexpression of miR-22 in the cultured cells resulted in decreased activity of interferon regulatory factor-3 and nuclear factor-kappa B, which in turn led to reduced expression of interferon-beta and inflammatory cytokines, including tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and chemokine (C-C motif) ligand 5, upon stimulation with poly(I:C), whereas knockdown of miR-22 had the opposite effect. poly 358-362 interferon beta 1 Homo sapiens 183-198 25609843-7 2015 Knockdown of the constitutively expressed DNA sensor DDX41 attenuates poly(dA:dT)-triggered IFN-beta production and cGAS induction. poly 70-74 interferon beta 1 Homo sapiens 92-100 27226571-8 2016 The phosphorylation of TLR3 on tyrosine 759 was shown to increase in parallel to IFN-beta production in an iNOS- and Src-dependent manner, and Src was found to directly interact with TLR3 in the endosomal compartment of poly(I:C)-treated cells. poly 220-224 interferon beta 1 Homo sapiens 81-89 25822580-4 2015 Co-stimulation with IFN-gamma and the TLR3 ligand poly (I:C) synergistically increased the expression of IFN-beta, IL-6, IL-8, and human beta-defensin-2 in NHEKs compared with poly (I:C) or IFN-gamma alone. poly 50-54 interferon beta 1 Homo sapiens 105-113 25515776-6 2015 Poly(dA:dT) induced the expression of pro-inflammatory cytokine genes including IFN-beta, TNF-alpha, IL-6 and IL-8 as well, whereas the pro-inflammatory cytokine production was suppressed by RIG-I siRNA, but not by AIM2 siRNA. poly 0-4 interferon beta 1 Homo sapiens 80-88 26635116-5 2016 Stimulation of the secretion by poly(I:C) was abolished by SB304680 (p38 inhibitor), LY294002 (PI3K inhibitor), Janus kinase (JAK) inhibitor I, RNA-activated protein kinase (PKR) inhibitor, and Bay 11-7082 (NF-kappaB inhibitor), while stimulation by IFN-beta was inhibited by all except Bay 11-7082. poly 32-36 interferon beta 1 Homo sapiens 250-258 26283481-6 2015 Using cell lines and primary airway epithelial cells (both submerged and well-differentiated), we observed that pure poly(I:C) stimulated IFN-beta mainly through the TLR3/TRIF pathway and IL-8 through an unidentified pathway. poly 117-121 interferon beta 1 Homo sapiens 138-146 26283481-11 2015 In conclusion, it is feasible to augment IFN-beta production in airway epithelial cells without excessive costimulation of IL-8 if the RIG-I/MAVS pathway is stimulated, such as via liposomal delivery of poly(I:C). poly 203-207 interferon beta 1 Homo sapiens 41-49 25609843-8 2015 By analyzing the dynamic expression of poly(dA:dT)-induced IFN-beta and cGAS transcripts, we have found that induction of IFN-beta is earlier than cGAS. poly 39-43 interferon beta 1 Homo sapiens 59-67 25609843-8 2015 By analyzing the dynamic expression of poly(dA:dT)-induced IFN-beta and cGAS transcripts, we have found that induction of IFN-beta is earlier than cGAS. poly 39-43 interferon beta 1 Homo sapiens 122-130 21952237-8 2011 Poly(I:C) was also shown to induce interferon (IFN)-beta mRNA expression in trophoblasts. poly 0-4 interferon beta 1 Homo sapiens 35-56 22065573-7 2011 We demonstrate that the TLR3 ligand polyriboinosinic:polyribocytidylic acid (poly(I:C)) induces expression and nuclear translocation of YinYang1 where it interacts with the IFN-beta promoter and inhibits the binding of IRF7 to the latter. poly 36-40 interferon beta 1 Homo sapiens 173-181 21952237-10 2011 Pretreating with neutralizing antibody against IFN-beta significantly suppressed IDO induction by poly(I:C). poly 98-102 interferon beta 1 Homo sapiens 47-55 20736039-0 2010 Loss-of-function mutations E6 27X and I923V of IFIH1 are associated with lower poly(I:C)-induced interferon-beta production in peripheral blood mononuclear cells of type 1 diabetes patients. poly 79-83 interferon beta 1 Homo sapiens 97-112 20519457-4 2010 In line with this hypothesis, expression of E3 ablated both IFN-beta expression and NF-kappaB activity in response to the dsDNA, poly(dA-dT). poly 129-133 interferon beta 1 Homo sapiens 60-68 20519457-8 2010 Consistent with this, RNA from poly(dA-dT) transfected cells induced IFN-beta and expression of the E3 dsRNA-binding domain was sufficient to ablate this response. poly 31-35 interferon beta 1 Homo sapiens 69-77 16704888-9 2006 IFN-alpha and IFN-beta, but not TNF-alpha or IL-6, were able to mimic the adjuvant effects of poly (I:C). poly 94-98 interferon beta 1 Homo sapiens 14-22 19452017-9 2009 RESULTS: The expressions of MIP1-alpha, MIP1-beta, IL-6, IL-8, RANTES, IFN-beta, and TLR3 were up-regulated in HCECs exposed to poly(I:C). poly 128-132 interferon beta 1 Homo sapiens 71-79 18771559-3 2008 Here we show that Legionella pneumophila infection, and intracellular challenge with poly(dA-dT), but not with poly(dG-dC), induced expression of IFNbeta, full-length hZBP1 and a prominent splice variant lacking the first Zalpha domain (hZBP1DeltaZalpha) in human cells. poly 85-89 interferon beta 1 Homo sapiens 146-153 18771559-4 2008 Overexpression of hZBP1 but not hZBP1DeltaZalpha slightly amplified poly(dA-dT)-stimulated IFNbeta reporter activation in HEK293 cells, but had no effect on IFNbeta and IL-8 production induced by bacteria or poly(dA-dT) in A549 cells. poly 68-72 interferon beta 1 Homo sapiens 91-98 18771559-5 2008 We found that mZBP1 siRNA impaired poly(dA-dT)-induced IFNbeta responses in mouse L929 fibroblasts at a later time point, while multiple hZBP1 siRNAs did not suppress IFNbeta or IL-8 expression induced by poly(dA-dT) or bacterial infection in human cells. poly 35-39 interferon beta 1 Homo sapiens 55-62 18771559-6 2008 In contrast, IRF3 siRNA strongly impaired the IFNbeta responses to poly(dA-dT) or bacterial infection. poly 67-71 interferon beta 1 Homo sapiens 46-53 18771559-7 2008 In conclusion, intracellular bacteria and cytosolic poly(dA-dT) activate IFNbeta responses in different human cells without requiring human ZBP1. poly 52-56 interferon beta 1 Homo sapiens 73-80 18199340-9 2008 IFN-beta production was induced after poly I:C/CHX treatment and neutralization of IFN-beta slightly reduced poly I:C/CHX -induced apoptosis. poly 38-42 interferon beta 1 Homo sapiens 0-8 18199340-9 2008 IFN-beta production was induced after poly I:C/CHX treatment and neutralization of IFN-beta slightly reduced poly I:C/CHX -induced apoptosis. poly 109-113 interferon beta 1 Homo sapiens 83-91 17669408-9 2008 Treatment of FTEC with TLR3 agonist poly(I:C) resulted in increased expression of interleukin-8, tumor-necrosis factor alpha, human beta-defensin 2, interferon beta, and interferon stimulated genes myxovirus resistance gene 1, 2",5"-oligoadenylate synthetase, and protein kinase R. Additionally, FTEC exposed to poly(I:C) also resulted in the induction of TLR2, TLR3, and TLR7. poly 36-40 interferon beta 1 Homo sapiens 149-164 1369307-1 1991 We screened for foodstuffs affecting interferon-beta (IFN-beta) production of human foreskin diploid fibroblasts, in the presence of poly I.poly C, cycloheximide, and actinomycin D. alpha- and beta-caseins stimulated IFN-beta production dose-dependently, but kappa-casein inhibited it. poly 133-137 interferon beta 1 Homo sapiens 37-52 16188991-10 2005 They produced IFN-beta after treatment with poly(I:C) but not with lipopolysaccharide. poly 44-48 interferon beta 1 Homo sapiens 14-22 8552072-7 1996 Sucrose gradient analysis of cytoplasmic extracts showed that IFN-beta transcripts with elongated poly(A) tails were found in the nonpolysomal fractions, whereas the shorter transcripts could be detected in both polysomal and nonpolysomal fractions. poly 98-102 interferon beta 1 Homo sapiens 62-70 11807004-6 2002 Finally, IL-3-IFN-beta DCs were found to produce much higher levels of IFN-alpha than IL-4-GM-CSF DCs in response to Poly (I:C) but not to influenza virus. poly 117-121 interferon beta 1 Homo sapiens 14-22 1602741-9 1992 Vascular SMC treated with poly(I):poly(C) or tumor necrosis factor-alpha expressed IFN-beta mRNA. poly 26-30 interferon beta 1 Homo sapiens 83-91 1369307-1 1991 We screened for foodstuffs affecting interferon-beta (IFN-beta) production of human foreskin diploid fibroblasts, in the presence of poly I.poly C, cycloheximide, and actinomycin D. alpha- and beta-caseins stimulated IFN-beta production dose-dependently, but kappa-casein inhibited it. poly 133-137 interferon beta 1 Homo sapiens 54-62 34739556-7 2022 Poly IC activated the TLR3 pathway, whereas knockdown of SMPDL3b attenuated poly IC-induced interferon-beta/chemokine C-X-C ligand 10 expression in podocytes. poly 76-80 interferon beta 1 Homo sapiens 92-107 3262700-10 1988 Simultaneous addition of TNF and poly(I).poly(C) to FS-4 cells enhanced IFN-beta synthesis. poly 33-37 interferon beta 1 Homo sapiens 72-80