PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
6575210-5	1983	In the absence of 17 beta-estradiol, 3-hydroxytamoxifen gave rise to a moderate increase in the progesterone receptor levels, which demonstrates the partially estrogenic character of hydroxytamoxifen.	hydroxytamoxifen	39-55	progesterone receptor	Homo sapiens	96-117	
15685451-6	2005	We, therefore, determined the effect of endoxifen and 4-OH-Tam on 17beta-estradiol (E2)-induced PR mRNA expression in an estrogen receptor-positive human breast cancer cell line.	hydroxytamoxifen	54-62	progesterone receptor	Homo sapiens	96-98	
15685451-12	2005	When 10(-10) M E2 was used, induction of the PR expression was observed in 2 h and reached its maximum at 24 h. In this assay, neither endoxifen nor 4-OH-Tam alone produced any change in the PR mRNA expression.	hydroxytamoxifen	149-157	progesterone receptor	Homo sapiens	45-47	
15685451-13	2005	However, both endoxifen and 4-OH-Tam decreased the E2-induced PR expression with similar potency.	hydroxytamoxifen	28-36	progesterone receptor	Homo sapiens	62-64	
1883484-4	1991	PR was significantly increased following treatment with 4-OH tamoxifen, this response being antagonized in the presence of ICI 164,384.	hydroxytamoxifen	56-70	progesterone receptor	Homo sapiens	0-2	
1965340-4	1990	We have found that: 1) cellular proliferation and estrogen or progesterone receptor concentration were mutually dependent, the greatest estradiol binding capacity was obtained in cells in which mitotic activity had been slowed down (G0/G1) by the antiestrogenic action of hydroxytamoxifen added to the culture; 2) the presence of estradiol in the culture medium induced marked changes in the synthesis and catabolism of estrogen and progesterone receptors; and 3) both receptors acted as functional proteins whose intracellular concentrations varied depending on the phases of the mitotic cycle.	hydroxytamoxifen	272-288	progesterone receptor	Homo sapiens	62-83	
2783569-3	1989	This response to EGF was dose dependent; a half-maximal effect was obtained at 10(-10) M. The antiestrogens tamoxifen and 4-hydroxytamoxifen were able to antagonize the stimulatory effect of EGF on progesterone receptor concentrations, but they did not affect its mitogenic effect.	hydroxytamoxifen	122-140	progesterone receptor	Homo sapiens	198-219	
2783569-4	1989	The inhibitory effect of 4-hydroxytamoxifen depended on concentration; half-maximal inhibition was observed between 0.5-1 X 10(-9) M. 4-Hydroxytamoxifen could completely inhibit the progesterone receptor increase due to EGF even when added to cells already exposed to the growth factor for 6 days.	hydroxytamoxifen	25-43	progesterone receptor	Homo sapiens	182-203	
2783569-4	1989	The inhibitory effect of 4-hydroxytamoxifen depended on concentration; half-maximal inhibition was observed between 0.5-1 X 10(-9) M. 4-Hydroxytamoxifen could completely inhibit the progesterone receptor increase due to EGF even when added to cells already exposed to the growth factor for 6 days.	hydroxytamoxifen	134-152	progesterone receptor	Homo sapiens	182-203	
3620717-3	1987	The antiestrogen 4-hydroxytamoxifen blocked progesterone receptor induction both by estradiol and by phenolphthalein.	hydroxytamoxifen	17-35	progesterone receptor	Homo sapiens	44-65	
7961858-2	1994	We have previously identified an intragenic (+698/+723) estrogen-responsive element present in the progesterone receptor gene, which binds the estradiol receptor and mediates estrogen and 4-OH tamoxifen induction.	hydroxytamoxifen	188-202	progesterone receptor	Homo sapiens	99-120	
7961858-3	1994	Progesterone receptor gene expression was equally stimulated by estradiol and 4-OH tamoxifen in the presence of a NH2 terminally deleted estrogen receptor mutant lacking activation function 1, suggesting that activation function 2 was the predominant activation domain.	hydroxytamoxifen	78-92	progesterone receptor	Homo sapiens	0-21	
29416786-8	2018	These genes, except PGR and CCND1 which were down-regulated, were also up-regulated in ER+ MCF-7 cells by 4-OH-TAM.	hydroxytamoxifen	106-114	progesterone receptor	Homo sapiens	20-23