PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20022493-1	2010	A variety of N-linked tertiary amines and heteroarylamines were examined at the 4-position of sulfonylated proline dipeptides in order to improve VLA-4 receptor off-rates and overcome the issue of CYP3A4 time-dependent inhibition of ester prodrugs.	Esters	233-238	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	197-203	
20405834-7	2010	Furthermore, it was demonstrated that 7-hydroxyraloxifene, which was previously believed to be a typical O(2)-derived metabolite of CYP3A4, is in fact produced by a highly unusual hydrolysis pathway from a putative ester, formed by the conjugation of raloxifene diquinone methide with a carboxylic acid moiety of CYP3A4, or other proteins in the reconstituted system.	Esters	215-220	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	132-138	
20405834-7	2010	Furthermore, it was demonstrated that 7-hydroxyraloxifene, which was previously believed to be a typical O(2)-derived metabolite of CYP3A4, is in fact produced by a highly unusual hydrolysis pathway from a putative ester, formed by the conjugation of raloxifene diquinone methide with a carboxylic acid moiety of CYP3A4, or other proteins in the reconstituted system.	Esters	215-220	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	313-319	
19158314-0	2009	CYP3A4-mediated ester cleavage as the major metabolic pathway of the oral taxane 3"-tert-butyl-3"-N-tert-butyloxycarbonyl-4-deacetyl-3"-dephenyl-3"-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183).	Esters	16-21	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6