PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24660685-4 2014 The ester prodrugs of 3 and 4 with diclofenac showed promising dual inhibition of NF-kappa B and COX-2. Esters 4-9 prostaglandin-endoperoxide synthase 2 Homo sapiens 97-102 26704937-0 2016 Conservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics. Esters 108-114 prostaglandin-endoperoxide synthase 2 Homo sapiens 45-61 26392530-1 2015 Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid (AA) and its ester analog, 2-arachidonoylglycerol (2-AG), to prostaglandins (PGs) and prostaglandin glyceryl esters (PG-Gs), respectively. Esters 66-71 prostaglandin-endoperoxide synthase 2 Homo sapiens 0-16 26392530-1 2015 Cyclooxygenase-2 (COX-2) oxygenates arachidonic acid (AA) and its ester analog, 2-arachidonoylglycerol (2-AG), to prostaglandins (PGs) and prostaglandin glyceryl esters (PG-Gs), respectively. Esters 66-71 prostaglandin-endoperoxide synthase 2 Homo sapiens 18-23 25596758-2 2015 Among the newly synthesized compounds, some of them were endowed with a good activity against COX-2 and a good selectivity COX-2/COX-1 in vitro as well as a desirable analgesic activity in vivo, proving that replacement of the ester moiety with an amide group gave access to more stable derivatives, characterized by a good COX-inhibition. Esters 227-232 prostaglandin-endoperoxide synthase 2 Homo sapiens 94-99 25596758-2 2015 Among the newly synthesized compounds, some of them were endowed with a good activity against COX-2 and a good selectivity COX-2/COX-1 in vitro as well as a desirable analgesic activity in vivo, proving that replacement of the ester moiety with an amide group gave access to more stable derivatives, characterized by a good COX-inhibition. Esters 227-232 prostaglandin-endoperoxide synthase 2 Homo sapiens 123-128 15857149-0 2005 1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors. Esters 37-43 prostaglandin-endoperoxide synthase 2 Homo sapiens 92-108 17764958-2 2007 These ester prodrugs (11) all exhibited in vitro inhibitory activity against the cyclooxygenase-2 (COX-2) isozyme (IC(50)=0.94-31.6 microM range). Esters 6-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 81-97 17764958-2 2007 These ester prodrugs (11) all exhibited in vitro inhibitory activity against the cyclooxygenase-2 (COX-2) isozyme (IC(50)=0.94-31.6 microM range). Esters 6-11 prostaglandin-endoperoxide synthase 2 Homo sapiens 99-104 34592918-8 2021 Interestingly, nabumetone, flurbiprofen axetil, piketoprofen-amide, and nepafenac are ester prodrugs that inhibit COX-2. Esters 86-91 prostaglandin-endoperoxide synthase 2 Homo sapiens 114-119 12135387-1 2002 Conversion of carboxylate-containing nonsteroidal antiinflammatory drugs, such as indomethacin, to esters or amides provides potent and selective inhibitors of cyclooxygenase-2 (COX-2) [Kalgutkar et al. Esters 99-105 prostaglandin-endoperoxide synthase 2 Homo sapiens 160-176 12135387-1 2002 Conversion of carboxylate-containing nonsteroidal antiinflammatory drugs, such as indomethacin, to esters or amides provides potent and selective inhibitors of cyclooxygenase-2 (COX-2) [Kalgutkar et al. Esters 99-105 prostaglandin-endoperoxide synthase 2 Homo sapiens 178-183 12086537-11 2002 For 16 indomethacin amides and esters (ImAE) inhibiting cyclooxygenase-2 (COX-2), a 6-variable QSAR model (M3) with RMSEE = 0.079 and r = 0.9839 and RMSEP = 0.151 and q = 0.9413 is built. Esters 31-37 prostaglandin-endoperoxide synthase 2 Homo sapiens 56-72 10956194-0 2000 Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. Esters 0-5 prostaglandin-endoperoxide synthase 2 Homo sapiens 98-114 10956194-13 2000 Conversion of indomethacin into ester and amide derivatives provides a facile strategy for generating highly selective COX-2 inhibitors and eliminating the gastrointestinal side effects of the parent compound. Esters 32-37 prostaglandin-endoperoxide synthase 2 Homo sapiens 119-124 27229194-2 2016 In an earlier study, a number of selective COX-2 inhibitors/NO donors were developed by conjugating a diarylpyrrole scaffold endowed with selective COX-2 inhibitory properties with various nitrooxyalkyl side chains such as esters, alpha-amino esters, amides, alpha-amino amides, ethers, beta-amino ethers, inverse esters, and amides. Esters 243-249 prostaglandin-endoperoxide synthase 2 Homo sapiens 43-48 27229194-2 2016 In an earlier study, a number of selective COX-2 inhibitors/NO donors were developed by conjugating a diarylpyrrole scaffold endowed with selective COX-2 inhibitory properties with various nitrooxyalkyl side chains such as esters, alpha-amino esters, amides, alpha-amino amides, ethers, beta-amino ethers, inverse esters, and amides. Esters 243-249 prostaglandin-endoperoxide synthase 2 Homo sapiens 148-153 31000626-1 2019 Many indomethacin amides and esters are cyclooxygenase-2 (COX-2)-selective inhibitors, providing a framework for the design of COX-2-targeted imaging and cancer chemotherapeutic agents. Esters 29-35 prostaglandin-endoperoxide synthase 2 Homo sapiens 40-56 31000626-1 2019 Many indomethacin amides and esters are cyclooxygenase-2 (COX-2)-selective inhibitors, providing a framework for the design of COX-2-targeted imaging and cancer chemotherapeutic agents. Esters 29-35 prostaglandin-endoperoxide synthase 2 Homo sapiens 58-63 31000626-1 2019 Many indomethacin amides and esters are cyclooxygenase-2 (COX-2)-selective inhibitors, providing a framework for the design of COX-2-targeted imaging and cancer chemotherapeutic agents. Esters 29-35 prostaglandin-endoperoxide synthase 2 Homo sapiens 127-132 27229194-2 2016 In an earlier study, a number of selective COX-2 inhibitors/NO donors were developed by conjugating a diarylpyrrole scaffold endowed with selective COX-2 inhibitory properties with various nitrooxyalkyl side chains such as esters, alpha-amino esters, amides, alpha-amino amides, ethers, beta-amino ethers, inverse esters, and amides. Esters 223-229 prostaglandin-endoperoxide synthase 2 Homo sapiens 43-48 27229194-2 2016 In an earlier study, a number of selective COX-2 inhibitors/NO donors were developed by conjugating a diarylpyrrole scaffold endowed with selective COX-2 inhibitory properties with various nitrooxyalkyl side chains such as esters, alpha-amino esters, amides, alpha-amino amides, ethers, beta-amino ethers, inverse esters, and amides. Esters 223-229 prostaglandin-endoperoxide synthase 2 Homo sapiens 148-153